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    Cep128 centrosomal protein 128 [ Mus musculus (house mouse) ]

    Gene ID: 75216, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cep128provided by MGI
    Official Full Name
    centrosomal protein 128provided by MGI
    Primary source
    MGI:MGI:1922466
    See related
    Ensembl:ENSMUSG00000061533 AllianceGenome:MGI:1922466
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E230024F20; 4930534B04Rik; 5430424K18Rik
    Summary
    Acts upstream of or within regulation of gene expression and sperm flagellum assembly. Located in centriole. Orthologous to human CEP128 (centrosomal protein 128). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 30.8), liver E14 (RPKM 3.1) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cep128 in Genome Data Viewer
    Location:
    12 D3; 12 44.08 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (90965264..91351207, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (90998490..91384455, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26512 Neighboring gene STARR-seq mESC enhancer starr_32925 Neighboring gene nuclear encoded rRNA 5S 65 Neighboring gene predicted gene, 23195 Neighboring gene STARR-seq mESC enhancer starr_32926 Neighboring gene STARR-seq mESC enhancer starr_32927 Neighboring gene RIKEN cDNA 5430427M07 gene Neighboring gene MOCO sulphurase C-terminal domain containing 2 pseudogene Neighboring gene phosphatidate cytidylyltransferase, mitochondrial pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr12:92497477-92497778 Neighboring gene STARR-seq mESC enhancer starr_32928 Neighboring gene STARR-seq mESC enhancer starr_32929 Neighboring gene predicted gene, 18388 Neighboring gene STARR-positive B cell enhancer ABC_E8495 Neighboring gene thyroid stimulating hormone receptor Neighboring gene phosphoglycerate mutase family member 5 pseudogene Neighboring gene predicted gene, 40541

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CEP128 is involved in spermatogenesis in humans and mice. Zhang X, et al. Nat Commun, 2022 Mar 16. PMID 35296684, Free PMC Article
    2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sperm flagellum assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of centriolar subdistal appendage IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm head-tail coupling apparatus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 128 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181815.3 → NP_861536.3  centrosomal protein of 128 kDa

      See identical proteins and their annotated locations for NP_861536.3

      Status: VALIDATED

      Source sequence(s)
      BC079647, CK634985
      Consensus CDS
      CCDS36515.2
      UniProtKB/Swiss-Prot
      Q8BI22
      UniProtKB/TrEMBL
      B7ZNX8
      Related
      ENSMUSP00000115679.2, ENSMUST00000141429.8
      Conserved Domains (1) summary
      pfam07851
      Location:612 → 705
      TMPIT; TMPIT-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      90965264..91351207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244197.3 → XP_011242499.1  centrosomal protein of 128 kDa isoform X6

      See identical proteins and their annotated locations for XP_011242499.1

      Conserved Domains (2) summary
      COG1196
      Location:222 → 602
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:48 → 367
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_030246965.2 → XP_030102825.1  centrosomal protein of 128 kDa isoform X3

      Conserved Domains (4) summary
      COG1196
      Location:406 → 786
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4372
      Location:268 → 491
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02169
      Location:694 → 925
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      TIGR03794
      Location:151 → 323
      NHLM_micro_HlyD; NHLM bacteriocin system secretion protein

    3. XM_011244195.4 → XP_011242497.1  centrosomal protein of 128 kDa isoform X2

      Conserved Domains (2) summary
      COG1196
      Location:406 → 786
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:222 → 544
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    4. XM_006516324.5 → XP_006516387.1  centrosomal protein of 128 kDa isoform X1

      Conserved Domains (1) summary
      COG1196
      Location:451 → 831
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. XM_017315228.3 → XP_017170717.1  centrosomal protein of 128 kDa isoform X4

      Conserved Domains (2) summary
      COG1196
      Location:295 → 675
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:23 → 795
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    6. XM_036157636.1 → XP_036013529.1  centrosomal protein of 128 kDa isoform X7

      Conserved Domains (2) summary
      COG1196
      Location:222 → 602
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:48 → 367
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    7. XM_030246966.2 → XP_030102826.1  centrosomal protein of 128 kDa isoform X6

      Conserved Domains (2) summary
      COG1196
      Location:222 → 602
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:48 → 367
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    8. XM_011244196.4 → XP_011242498.1  centrosomal protein of 128 kDa isoform X5

      Conserved Domains (3) summary
      COG1196
      Location:451 → 831
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:281 → 612
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      TIGR03794
      Location:151 → 323
      NHLM_micro_HlyD; NHLM bacteriocin system secretion protein

    RNA

    1. XR_001780497.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BI22.2 GenPept UniProtKB/Swiss-Prot:Q8BI22

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