Ranbp10 RAN binding protein 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ranbp10provided by MGI
Official Full Name: RAN binding protein 10provided by MGI
Primary source: MGI:MGI:1921584
See related: Ensembl:ENSMUSG00000037415 AllianceGenome:MGI:1921584
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4432417N03Rik
Summary: Enables beta-tubulin binding activity; guanyl-nucleotide exchange factor activity; and small GTPase binding activity. Acts upstream of or within microtubule cytoskeleton organization. Located in cytoplasm and microtubule cytoskeleton. Is expressed in several structures, including adrenal gland; genitourinary system; gut; liver; and nervous system. Orthologous to human RANBP10 (RAN binding protein 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver E14.5 (RPKM 43.4), liver E14 (RPKM 37.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.04 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (106494940..106560463, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (105768308..105833831, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RanBP10 inhibits premature microtubule polymerization of beta1-tubulin and plays a pivotal role in thrombus stabilization.
Title: Altered microtubule equilibrium and impaired thrombus stability in mice lacking RanBP10.
Data suggest that RanBP10 plays an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function.
Title: The microtubule modulator RanBP10 plays a critical role in regulation of platelet discoid shape and degranulation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Mit256 (e-PCR), detects polymorphism
- UniSTS:128601

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ran-binding protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145824.5 → NP_665823.3 ran-binding protein 10

Status: VALIDATED

Source sequence(s)

AC152826

Consensus CDS

CCDS22613.1

UniProtKB/Swiss-Prot

Q69ZJ1, Q6VN19, Q8C328, Q8R1E6

UniProtKB/TrEMBL

A0A0R4J0G4, A9UGK3

Related

ENSMUSP00000159340.2, ENSMUST00000239468.2

Conserved Domains (4) summary

smart00667
Location:257 → 284

LisH; Lissencephaly type-1-like homology motif

smart00668
Location:291 → 347

CTLH; C-terminal to LisH motif

smart00757
Location:507 → 604

CRA; CT11-RanBPM

cd12909
Location:77 → 219

SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

106494940..106560463 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030243813.1 → XP_030099673.1 ran-binding protein 10 isoform X1

Conserved Domains (4) summary

smart00667
Location:150 → 177

LisH; Lissencephaly type-1-like homology motif

smart00757
Location:400 → 497

CRA; CT11-RanBPM

cd12909
Location:10 → 112

SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10

pfam10607
Location:184 → 238

CLTH; CTLH/CRA C-terminal to LisH motif domain
XM_030243815.1 → XP_030099675.1 ran-binding protein 10 isoform X3

Conserved Domains (3) summary

smart00667
Location:28 → 55

LisH; Lissencephaly type-1-like homology motif

smart00668
Location:62 → 118

CTLH; C-terminal to LisH motif

smart00757
Location:278 → 375

CRA; CT11-RanBPM
XM_030243814.1 → XP_030099674.1 ran-binding protein 10 isoform X2

Conserved Domains (4) summary

smart00667
Location:125 → 152

LisH; Lissencephaly type-1-like homology motif

smart00757
Location:375 → 472

CRA; CT11-RanBPM

pfam10607
Location:159 → 213

CLTH; CTLH/CRA C-terminal to LisH motif domain

cl02614
Location:2 → 87

SPRY; SPRY domain
XM_006531426.1 → XP_006531489.1 ran-binding protein 10 isoform X3

See identical proteins and their annotated locations for XP_006531489.1

Conserved Domains (3) summary

smart00667
Location:28 → 55

LisH; Lissencephaly type-1-like homology motif

smart00668
Location:62 → 118

CTLH; C-terminal to LisH motif

smart00757
Location:278 → 375

CRA; CT11-RanBPM
XM_011248526.1 → XP_011246828.1 ran-binding protein 10 isoform X3

See identical proteins and their annotated locations for XP_011246828.1

Conserved Domains (3) summary

smart00667
Location:28 → 55

LisH; Lissencephaly type-1-like homology motif

smart00668
Location:62 → 118

CTLH; C-terminal to LisH motif

smart00757
Location:278 → 375

CRA; CT11-RanBPM
XM_006531428.5 → XP_006531491.1 ran-binding protein 10 isoform X4

Conserved Domains (3) summary

smart00668
Location:32 → 88

CTLH; C-terminal to LisH motif

smart00757
Location:248 → 345

CRA; CT11-RanBPM

cl26729
Location:1 → 20

LisH