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    Pop5 processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 117109, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pop5provided by MGI
    Official Full Name
    processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:2151221
    See related
    Ensembl:ENSMUSG00000060152 AllianceGenome:MGI:2151221
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rnasep3; 1500019J17Rik; 2700077E03Rik
    Summary
    Enables ribonuclease P activity. Acts upstream of or within tRNA processing. Part of nucleolar ribonuclease P complex. Is expressed in Meckel's cartilage and skeleton. Orthologous to human POP5 (POP5 homolog, ribonuclease P/MRP subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 61.9), kidney adult (RPKM 33.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pop5 in Genome Data Viewer
    Location:
    5 F; 5 56.01 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115373505..115379031)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (115235588..115240972)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1058 Neighboring gene malectin Neighboring gene STARR-seq mESC enhancer starr_14105 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:115617496-115617679 Neighboring gene calcium binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_14108 Neighboring gene STARR-seq mESC enhancer starr_14109 Neighboring gene predicted gene, 35515 Neighboring gene STARR-seq mESC enhancer starr_14111 Neighboring gene STARR-positive B cell enhancer ABC_E8072 Neighboring gene ring finger protein 10 Neighboring gene STARR-seq mESC enhancer starr_14112 Neighboring gene STARR-positive B cell enhancer ABC_E3605 Neighboring gene STARR-seq mESC enhancer starr_14114 Neighboring gene coenzyme Q5 methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. hPop5, a protein subunit of the human RNase MRP and RNase P endoribonucleases. van Eenennaam H, et al. J Biol Chem, 2001 Aug 24. PMID 11413139
    2. Eukaryotic ribonuclease P: a plurality of ribonucleoprotein enzymes. Xiao S, et al. Annu Rev Biochem, 2002. PMID 12045094, Free PMC Article
    3. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909
    4. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    5. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ribonuclease MRP activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables ribonuclease P RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonuclease P RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribonuclease P RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribonuclease P activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to ribonuclease P activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within rRNA processing ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in tRNA 5'-leader removal IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA 5'-leader removal ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA 5'-leader removal ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within tRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of multimeric ribonuclease P complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of multimeric ribonuclease P complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleolar ribonuclease P complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonuclease MRP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonuclease MRP complex ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    part_of ribonuclease MRP complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ribonuclease P/MRP protein subunit POP5
    NP_001390591.1
    NP_080674.1
    XP_030109934.1
    XP_036020636.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403662.1 → NP_001390591.1  ribonuclease P/MRP protein subunit POP5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC145070

    2. NM_026398.5 → NP_080674.1  ribonuclease P/MRP protein subunit POP5 isoform 1

      See identical proteins and their annotated locations for NP_080674.1

      Status: VALIDATED

      Source sequence(s)
      AC145070
      Consensus CDS
      CCDS19583.1
      UniProtKB/Swiss-Prot
      Q9CSC3, Q9CSL4, Q9DB28
      Related
      ENSMUSP00000080215.7, ENSMUST00000081497.13
      Conserved Domains (1) summary
      pfam01900
      Location:7 → 115
      RNase_P_Rpp14; Rpp14/Pop5 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      115373505..115379031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164743.1 → XP_036020636.1  ribonuclease P/MRP protein subunit POP5 isoform X1

      UniProtKB/Swiss-Prot
      Q9CSC3, Q9CSL4, Q9DB28
      Conserved Domains (1) summary
      pfam01900
      Location:7 → 115
      RNase_P_Rpp14; Rpp14/Pop5 family

    2. XM_030254074.2 → XP_030109934.1  ribonuclease P/MRP protein subunit POP5 isoform X1

      UniProtKB/Swiss-Prot
      Q9CSC3, Q9CSL4, Q9DB28
      Related
      ENSMUSP00000118408.2, ENSMUST00000135455.2
      Conserved Domains (1) summary
      pfam01900
      Location:7 → 115
      RNase_P_Rpp14; Rpp14/Pop5 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DB28.1 GenPept UniProtKB/Swiss-Prot:Q9DB28

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