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    Tmem270 transmembrane protein 270 [ Mus musculus (house mouse) ]

    Gene ID: 76629, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tmem270provided by MGI
    Official Full Name
    transmembrane protein 270provided by MGI
    Primary source
    MGI:MGI:1923879
    See related
    Ensembl:ENSMUSG00000040576 AllianceGenome:MGI:1923879
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wbscr28; 1700111I05Rik
    Summary
    Predicted to be located in membrane. Orthologous to human TMEM270 (transmembrane protein 270). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 99.9) See more
    Orthologs
    human all
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    Genomic context

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    See Tmem270 in Genome Data Viewer
    Location:
    5 G2; 5 74.88 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (134930447..134935587, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (134901593..134906733, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene LIM domain kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E1309 Neighboring gene predicted gene 10369 Neighboring gene STARR-positive B cell enhancer mm9_chr5:135180028-135180329 Neighboring gene elastin Neighboring gene predicted gene, 30003 Neighboring gene STARR-seq mESC enhancer starr_14552 Neighboring gene STARR-seq mESC enhancer starr_14554 Neighboring gene RIKEN cDNA 9030607J07 gene Neighboring gene STARR-positive B cell enhancer ABC_E1310 Neighboring gene claudin 13 Neighboring gene methyltransferase like 27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†. Lu Y, et al. Biol Reprod, 2019 Aug 1. PMID 31201419, Free PMC Article
    2. Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome. DeSilva U, et al. Genome Res, 2002 Jan. PMID 11779826, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC141057

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 270
    Names
    Williams-Beuren syndrome chromosome region 28
    Williams-Beuren syndrome critical region 28
    williams-Beuren syndrome chromosomal region 28 protein homolog

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029681.3 → NP_083957.1  transmembrane protein 270 isoform b

      See identical proteins and their annotated locations for NP_083957.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting protein (isoform b) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK007170, AV209462
      Consensus CDS
      CCDS39313.1
      UniProtKB/Swiss-Prot
      Q6UJB9
      Related
      ENSMUSP00000045190.6, ENSMUST00000047305.6
      Conserved Domains (1) summary
      pfam15164
      Location:1 → 170
      WBS28; Williams-Beuren syndrome chromosomal region 28 protein homologue

    2. NM_194065.3 → NP_919041.1  transmembrane protein 270 isoform a

      See identical proteins and their annotated locations for NP_919041.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (a).
      Source sequence(s)
      AV209462, BC114542
      Consensus CDS
      CCDS80423.1
      UniProtKB/Swiss-Prot
      Q6UJB9, Q9D9B5
      Related
      ENSMUSP00000144496.2, ENSMUST00000201316.4
      Conserved Domains (1) summary
      pfam15164
      Location:1 → 264
      WBS28; Williams-Beuren syndrome chromosomal region 28 protein homologue

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      134930447..134935587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UJB9.1 GenPept UniProtKB/Swiss-Prot:Q6UJB9

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