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    Crip2 cysteine rich protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 68337, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Crip2provided by MGI
    Official Full Name
    cysteine rich protein 2provided by MGI
    Primary source
    MGI:MGI:1915587
    See related
    Ensembl:ENSMUSG00000006356 AllianceGenome:MGI:1915587
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crp; Hlp; CRP2; CRP4; ESP1; 0610010I23Rik
    Summary
    Predicted to enable metal ion binding activity. Acts upstream of or within hemopoiesis and positive regulation of cell population proliferation. Located in cell cortex. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human CRIP2 (cysteine rich protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in heart adult (RPKM 931.2), lung adult (RPKM 531.1) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Crip2 in Genome Data Viewer
    Location:
    12 F1; 12 61.57 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (113103856..113109126)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (113140236..113145506)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene metastasis associated 1 Neighboring gene RIKEN cDNA F930026P19 gene Neighboring gene predicted gene, 30599 Neighboring gene cysteine-rich protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cyclic GMP-Dependent Regulation of Vascular Tone and Blood Pressure Involves Cysteine-Rich LIM-Only Protein 4 (CRP4). Längst N, et al. Int J Mol Sci, 2021 Sep 14. PMID 34576086, Free PMC Article
    2. Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3. Karim MA, et al. Genomics, 1996 Jan 15. PMID 8824798
    3. Cysteine-rich protein 2, a novel downstream effector of cGMP/cGMP-dependent protein kinase I-mediated persistent inflammatory pain. Schmidtko A, et al. J Neurosci, 2008 Feb 6. PMID 18256252, Free PMC Article
    4. Cysteine-Rich LIM-Only Protein 4 (CRP4) Promotes Atherogenesis in the ApoE(-/-) Mouse Model. Längst N, et al. Cells, 2022 Apr 17. PMID 35456043, Free PMC Article
    5. Amplified pathogenic actions of angiotensin II in cysteine-rich LIM-only protein 4-negative mouse hearts. Straubinger J, et al. FASEB J, 2017 Apr. PMID 28138039

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HOXA9 inhibits HIF1A-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development.
      Title: HOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development.
    2. The persistence of Crip2 expression in cardiovascular tissues implies that Crip2 might exert an important impact on the cardiovascular development, maintenance and homeostasis.
      Title: Expression of Crip2, a LIM-domain-only protein, in the mouse cardiovascular system under physiological and pathological conditions.
    3. role for the two LIM-domain gene Hlp in the very earliest stages of heart differentiation and development
      Title: The heart LIM protein gene (Hlp), expressed in the developing and adult heart, defines a new tissue-specific LIM-only protein family.
    4. observed characteristics of the LIM domain-containing adaptor protein CRIP2 are consistent with a potential role of PTP-BL in the dynamics of the cortical actin cytoskeleton
      Title: Cloning and characterization of mCRIP2, a mouse LIM-only protein that interacts with PDZ domain IV of PTP-BL.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within hemopoiesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cysteine-rich protein 2
    Names
    CRP-2
    LIM only protein HLP
    heart LIM protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347443.1 → NP_001334372.1  cysteine-rich protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC073562, AI851454, AK002484
      Consensus CDS
      CCDS84005.1
      UniProtKB/TrEMBL
      A0A0G2JF37
      Related
      ENSMUSP00000143334.2, ENSMUST00000200380.5
      Conserved Domains (1) summary
      cd09476
      Location:2 → 55
      LIM1_TLP; The first LIM domain of thymus LIM protein (TLP)

    2. NM_024223.2 → NP_077185.1  cysteine-rich protein 2 isoform 1

      See identical proteins and their annotated locations for NP_077185.1

      Status: VALIDATED

      Source sequence(s)
      AI851454, AK002484, CX217539
      Consensus CDS
      CCDS26204.1
      UniProtKB/Swiss-Prot
      Q9DCT8
      UniProtKB/TrEMBL
      Q4FJU3
      Related
      ENSMUSP00000081943.5, ENSMUST00000084882.9
      Conserved Domains (1) summary
      cd09476
      Location:5 → 58
      LIM1_TLP; The first LIM domain of thymus LIM protein (TLP)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      113103856..113109126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246890.2 → XP_030102750.1  cysteine-rich protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JF37
      Related
      ENSMUSP00000143009.2, ENSMUST00000196015.5
      Conserved Domains (1) summary
      cd09476
      Location:2 → 55
      LIM1_TLP; The first LIM domain of thymus LIM protein (TLP)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCT8.1 GenPept UniProtKB/Swiss-Prot:Q9DCT8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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