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    Esrrg estrogen-related receptor gamma [ Mus musculus (house mouse) ]

    Gene ID: 26381, updated on 9-Nov-2024

    Summary

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    Official Symbol
    Esrrgprovided by MGI
    Official Full Name
    estrogen-related receptor gammaprovided by MGI
    Primary source
    MGI:MGI:1347056
    See related
    Ensembl:ENSMUSG00000026610 AllianceGenome:MGI:1347056
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ERR3; Errg; NR3B3; mKIAA0832
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and estrogen response element binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and sensory organ. Orthologous to human ESRRG (estrogen related receptor gamma). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 6.9), kidney adult (RPKM 4.9) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Esrrg in Genome Data Viewer
    Location:
    1 H5- H6; 1 91.83 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (187340707..187947082)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (187608510..188214885)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36249 Neighboring gene predicted gene, 36388 Neighboring gene predicted gene, 46176 Neighboring gene predicted gene, 53517 Neighboring gene STARR-seq mESC enhancer starr_03371 Neighboring gene VISTA enhancer mm111 Neighboring gene STARR-seq mESC enhancer starr_03373 Neighboring gene RIKEN cDNA 9330162B11 gene Neighboring gene STARR-seq mESC enhancer starr_03374 Neighboring gene predicted gene, 51738 Neighboring gene usherin Neighboring gene STARR-seq mESC enhancer starr_03375 Neighboring gene STARR-seq mESC enhancer starr_03376 Neighboring gene predicted gene, 39735 Neighboring gene predicted gene, 36456

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivity. Greschik H, et al. J Biol Chem, 2004 Aug 6. PMID 15161930
    2. Estrogen receptor-related receptor γ regulates testicular steroidogenesis through direct and indirect regulation of steroidogenic gene expression. Park E, et al. Mol Cell Endocrinol, 2017 Sep 5. PMID 28479375
    3. Androgen-Dependent Repression of ERRγ Reprograms Metabolism in Prostate Cancer. Audet-Walsh É, et al. Cancer Res, 2017 Jan 15. PMID 27821488
    4. ERRγ Preserves Brown Fat Innate Thermogenic Activity. Ahmadian M, et al. Cell Rep, 2018 Mar 13. PMID 29539415, Free PMC Article
    5. O-GlcNAcylation of Orphan Nuclear Receptor Estrogen-Related Receptor γ Promotes Hepatic Gluconeogenesis. Misra J, et al. Diabetes, 2016 Oct. PMID 27335230

    See all (136) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Metabolic regulator ERRgamma governs gastric stem cell differentiation into acid-secreting parietal cells.
      Title: Metabolic regulator ERRγ governs gastric stem cell differentiation into acid-secreting parietal cells.
    2. ESRRG-controlled downregulation of KCNN1 in primary sensory neurons is required for neuropathic pain.
      Title: ESRRG-controlled downregulation of KCNN1 in primary sensory neurons is required for neuropathic pain.
    3. Upregulation of the ERRgamma-VDAC1 axis underlies the molecular pathogenesis of pancreatitis.
      Title: Upregulation of the ERRγ-VDAC1 axis underlies the molecular pathogenesis of pancreatitis.
    4. Estrogen-related receptor gamma (ERRgamma) is a key regulator of lysyl oxidase gene expression in mouse hepatocytes.
      Title: Estrogen-related receptor γ (ERRγ) is a key regulator of lysyl oxidase gene expression in mouse hepatocytes.
    5. ERR2 and ERR3 promote the development of gamma motor neuron functional properties required for proprioceptive movement control.
      Title: ERR2 and ERR3 promote the development of gamma motor neuron functional properties required for proprioceptive movement control.
    6. Lupus susceptibility gene Esrrg modulates regulatory T cells through mitochondrial metabolism.
      Title: Lupus susceptibility gene Esrrg modulates regulatory T cells through mitochondrial metabolism.
    7. Orphan nuclear receptor ERRgamma regulates hepatic TGF-beta2 expression and fibrogenic response in CCl4-induced acute liver injury.
      Title: Orphan nuclear receptor ERRγ regulates hepatic TGF-β2 expression and fibrogenic response in CCl(4)-induced acute liver injury.
    8. Orphan nuclear receptor ERR-gamma regulates hepatic FGF23 production in acute kidney injury.
      Title: Orphan nuclear receptor ERR-γ regulates hepatic FGF23 production in acute kidney injury.
    9. Cardiac-Specific Overexpression of ERRgamma in Mice Induces Severe Heart Dysfunction and Early Lethality.
      Title: Cardiac-Specific Overexpression of ERRγ in Mice Induces Severe Heart Dysfunction and Early Lethality.
    10. A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation.
      Title: A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation.
    Submit: New GeneRIF Correction See all GeneRIFs (65)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (7)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables estrogen response element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables estrogen response element binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables nuclear steroid receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear receptor-mediated steroid hormone signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retinoic acid receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in steroid hormone receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    estrogen-related receptor gamma
    Names
    estrogen receptor-related protein 3
    estrogen-related receptor 3
    nuclear receptor subfamily 3 group B member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243792.1 → NP_001230721.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001230721.1

      Status: VALIDATED

      Source sequence(s)
      AK052731, BC082324, BY067844
      Consensus CDS
      CCDS56666.1
      UniProtKB/Swiss-Prot
      P62509
      Related
      ENSMUSP00000106564.2, ENSMUST00000110939.8
      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    2. NM_001357534.1 → NP_001344463.1  estrogen-related receptor gamma isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC109296, AC115061, AC116380, AC122122
      Consensus CDS
      CCDS56666.1
      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    3. NM_001357535.1 → NP_001344464.1  estrogen-related receptor gamma isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC109296, AC115061, AC116380, AC122122
      Consensus CDS
      CCDS56666.1
      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    4. NM_001357536.1 → NP_001344465.1  estrogen-related receptor gamma isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC116380, AC122122
      Conserved Domains (2) summary
      cd06946
      Location:220 → 439
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:105 → 201
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    5. NM_011935.3 → NP_036065.1  estrogen-related receptor gamma isoform 1

      See identical proteins and their annotated locations for NP_036065.1

      Status: VALIDATED

      Source sequence(s)
      BC082324, CJ062694
      Consensus CDS
      CCDS15606.1
      UniProtKB/Swiss-Prot
      P62509, Q8CHC9
      Related
      ENSMUSP00000027906.7, ENSMUST00000027906.13
      Conserved Domains (2) summary
      cd06946
      Location:237 → 456
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:122 → 218
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      187340707..187947082
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238916.4 → XP_011237218.1  estrogen-related receptor gamma isoform X1

      See identical proteins and their annotated locations for XP_011237218.1

      Conserved Domains (2) summary
      cd06946
      Location:226 → 445
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:111 → 207
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    2. XM_006497165.5 → XP_006497228.1  estrogen-related receptor gamma isoform X3

      See identical proteins and their annotated locations for XP_006497228.1

      UniProtKB/Swiss-Prot
      P62509
      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    3. XM_036165240.1 → XP_036021133.1  estrogen-related receptor gamma isoform X3

      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    4. XM_011238917.4 → XP_011237219.1  estrogen-related receptor gamma isoform X1

      See identical proteins and their annotated locations for XP_011237219.1

      Conserved Domains (2) summary
      cd06946
      Location:226 → 445
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:111 → 207
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    5. XM_011238920.4 → XP_011237222.1  estrogen-related receptor gamma isoform X1

      See identical proteins and their annotated locations for XP_011237222.1

      Conserved Domains (2) summary
      cd06946
      Location:226 → 445
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:111 → 207
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    6. XM_011238918.4 → XP_011237220.1  estrogen-related receptor gamma isoform X1

      See identical proteins and their annotated locations for XP_011237220.1

      Conserved Domains (2) summary
      cd06946
      Location:226 → 445
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:111 → 207
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    7. XM_011238915.4 → XP_011237217.1  estrogen-related receptor gamma isoform X1

      See identical proteins and their annotated locations for XP_011237217.1

      Conserved Domains (2) summary
      cd06946
      Location:226 → 445
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:111 → 207
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    8. XM_030254422.2 → XP_030110282.1  estrogen-related receptor gamma isoform X1

      Conserved Domains (2) summary
      cd06946
      Location:226 → 445
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:111 → 207
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    9. XM_036165247.1 → XP_036021140.1  estrogen-related receptor gamma isoform X3

      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    10. XM_011238919.4 → XP_011237221.1  estrogen-related receptor gamma isoform X1

      See identical proteins and their annotated locations for XP_011237221.1

      Conserved Domains (2) summary
      cd06946
      Location:226 → 445
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:111 → 207
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    11. XM_036165239.1 → XP_036021132.1  estrogen-related receptor gamma isoform X3

      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    12. XM_036165237.1 → XP_036021130.1  estrogen-related receptor gamma isoform X1

      Conserved Domains (2) summary
      cd06946
      Location:226 → 445
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:111 → 207
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    13. XM_036165242.1 → XP_036021135.1  estrogen-related receptor gamma isoform X3

      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    14. XM_036165250.1 → XP_036021143.1  estrogen-related receptor gamma isoform X3

      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    15. XM_006497170.3 → XP_006497233.1  estrogen-related receptor gamma isoform X3

      See identical proteins and their annotated locations for XP_006497233.1

      UniProtKB/Swiss-Prot
      P62509
      Related
      ENSMUSP00000106563.2, ENSMUST00000110938.2
      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    16. XM_030254424.2 → XP_030110284.1  estrogen-related receptor gamma isoform X2

      Conserved Domains (2) summary
      cd06946
      Location:224 → 443
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:109 → 205
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62509.1 GenPept UniProtKB/Swiss-Prot:P62509

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