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    HHC2:067347 HHc2:067347 enhancer downstream of MEIS1 [ Homo sapiens (human) ]

    Gene ID: 111258511, updated on 10-Oct-2023

    Summary

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    Gene symbol
    HHC2:067347
    Gene description
    HHc2:067347 enhancer downstream of MEIS1
    Gene type
    biological region
    Feature type(s)
    regulatory: DNase_I_hypersensitive_site, enhancer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This region contains multiple DNase I hypersensitive sites and enhancer elements located downstream of the MEIS1 gene. One of the enhancer elements is able to drive expression of a reporter transgene in the developing nervous system. [provided by RefSeq, Oct 2017]
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    Genomic context

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    Location:
    chromosome: 2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (66574775..66579843)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (66583840..66588904)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (66801907..66806975)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:66666573-66667772 Neighboring gene E2 enhancer in MEIS1 Neighboring gene HHc2:066588 enhancer in MEIS1 Neighboring gene MEIS1 antisense RNA 2 Neighboring gene E5 enhancer in MEIS1 Neighboring gene Meis homeobox 1 Neighboring gene HHc2:066628 enhancer in MEIS1 Neighboring gene E7 enhancer in MEIS1 Neighboring gene uncharacterized LOC124900511 Neighboring gene HCNR606 enhancer in MEIS1 Neighboring gene HHc2:066650 enhancer in MEIS1 Neighboring gene HHc2:066659 enhancer in MEIS1 Neighboring gene HCNR617 enhancer in MEIS1 Neighboring gene HHc2:067135 enhancer in MEIS1 Neighboring gene long intergenic non-protein coding RNA 1798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:66874822-66875386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:66875387-66875950 Neighboring gene long intergenic non-protein coding RNA 1797 Neighboring gene DNA methyltransferase 3A pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Delineating MEIS1 cis-regulatory elements active in hematopoietic cells. Xiang P, et al. Leukemia, 2014 Feb. PMID 24097337
    2. Identification and analysis of conserved cis-regulatory regions of the MEIS1 gene. Royo JL, et al. PLoS One, 2012. PMID 22448256, Free PMC Article
    3. Toward a complete human genome sequence. Sanger Center, et al. Genome Res, 1998 Nov. PMID 9847074

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See Variation Viewer (GRCh37.p13)

    General gene information

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    Other Names

    • E3 enhancer downstream of MEIS1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_055605.1 

      Range
      101..5169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      66574775..66579843
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      66583840..66588904
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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