Ret ret proto-oncogene [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Retprovided by MGI
Official Full Name: ret proto-oncogeneprovided by MGI
Primary source: MGI:MGI:97902
See related: Ensembl:ENSMUSG00000030110 AllianceGenome:MGI:97902
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PTC; RET9; RET51; c-Ret
Summary: Enables transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including Peyer's patch morphogenesis; neuron cell-cell adhesion; and positive regulation of metanephric glomerulus development. Acts upstream of or within several processes, including nervous system development; positive regulation of cell size; and positive regulation of macromolecule metabolic process. Predicted to be located in dendrite; endosome; and neuronal cell body. Predicted to be part of plasma membrane protein complex and receptor complex. Predicted to be active in axon and plasma membrane. Is expressed in several structures, including branchial arch; genitourinary system; gut; nervous system; and sensory organ. Used to study Hirschsprung's disease; clubfoot; multiple endocrine neoplasia type 2B; and pheochromocytoma. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; familial medullary thyroid carcinoma; multiple endocrine neoplasia type 2A; multiple endocrine neoplasia type 2B; and pheochromocytoma. Orthologous to human RET (ret proto-oncogene). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cerebellum adult (RPKM 5.3), subcutaneous fat pad adult (RPKM 4.5) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F1; 6 55.86 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (118128709..118174705, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (118151748..118197744, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mesenchymal cells regulate enteric neural crest cell migration via RET-GFRA1b trans-signaling.
Title: Mesenchymal cells regulate enteric neural crest cell migration via RET-GFRA1b trans-signaling.
RET Signaling Persists in the Adult Intestine and Stimulates Motility by Limiting PYY Release From Enteroendocrine Cells.
Title: RET Signaling Persists in the Adult Intestine and Stimulates Motility by Limiting PYY Release From Enteroendocrine Cells.
Ret deficiency decreases neural crest progenitor proliferation and restricts fate potential during enteric nervous system development.
Title: Ret deficiency decreases neural crest progenitor proliferation and restricts fate potential during enteric nervous system development.
ASH2L Controls Ureteric Bud Morphogenesis through the Regulation of RET/GFRA1 Signaling Activity in a Mouse Model.
Title: ASH2L Controls Ureteric Bud Morphogenesis through the Regulation of RET/GFRA1 Signaling Activity in a Mouse Model.
A Single RET Mutation in Hirschsprung Disease Induces Intestinal Aganglionosis Via a Dominant-Negative Mechanism.
Title: A Single RET Mutation in Hirschsprung Disease Induces Intestinal Aganglionosis Via a Dominant-Negative Mechanism.
The kinase PLK1 promotes the development of Kras/Tp53-mutant lung adenocarcinoma through transcriptional activation of the receptor RET.
Title: The kinase PLK1 promotes the development of Kras/Tp53-mutant lung adenocarcinoma through transcriptional activation of the receptor RET.
Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons.
Title: Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons.
GIPC2 is an endocrine-specific tumor suppressor gene for both sporadic and hereditary tumors of RET- and SDHB-, but not VHL-associated clusters of pheochromocytoma/paraganglioma.
Title: GIPC2 is an endocrine-specific tumor suppressor gene for both sporadic and hereditary tumors of RET- and SDHB-, but not VHL-associated clusters of pheochromocytoma/paraganglioma.
Loss-of-function mutation of c-Ret causes cerebellar hypoplasia in mice with Hirschsprung disease and Down's syndrome.
Title: Loss-of-function mutation of c-Ret causes cerebellar hypoplasia in mice with Hirschsprung disease and Down's syndrome.
Hair graying with aging in mice carrying oncogenic RET.
Title: Hair graying with aging in mice carrying oncogenic RET.

Submit: New GeneRIF Correction See all GeneRIFs (132)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (48) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ret (e-PCR), detects polymorphism
- UniSTS:497282

Ret (e-PCR), detects polymorphism
- UniSTS:470677

Ret (e-PCR), detects polymorphism
- UniSTS:144346

Ret (e-PCR), detects polymorphism
- UniSTS:527072

Ret (e-PCR), detects polymorphism
- UniSTS:465405

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane receptor protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in GDF15-GFRAL signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in GDF15-GFRAL signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Peyer's patch morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anatomical structure morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to retinoic acid	IEA Inferred from Electronic Annotation more info
involved_in cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic epithelial tube formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within enteric nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell-derived neurotrophic factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in glial cell-derived neurotrophic factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in innervation	IEA Inferred from Electronic Annotation more info
involved_in innervation	ISO Inferred from Sequence Orthology more info
involved_in membrane protein proteolysis	IEA Inferred from Electronic Annotation more info
involved_in membrane protein proteolysis	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of metanephric glomerulus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron maturation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation of STAT protein	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in retina development in camera-type eye	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ureter maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ureteric bud development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of plasma membrane protein complex	IEA Inferred from Electronic Annotation more info
part_of plasma membrane protein complex	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: proto-oncogene tyrosine-protein kinase receptor Ret

Names: proto-oncogene c-Ret

NP_001074249.1

EC 2.7.10.1

NP_033076.2

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080780.1 → NP_001074249.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform c precursor

See identical proteins and their annotated locations for NP_001074249.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) represents the longer transcript but encodes the shorter isoform (c). This isoform is also known as Ret9.

Source sequence(s)

AC135861, AC156396, BC059012

Consensus CDS

CCDS39608.1

UniProtKB/Swiss-Prot

P35546

Related

ENSMUSP00000086169.4, ENSMUST00000088790.9

Conserved Domains (3) summary

cd05045
Location:724 → 1013

PTKc_RET; Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein

pfam00028
Location:173 → 262

Cadherin; Cadherin domain

pfam07714
Location:725 → 1006

Pkinase_Tyr; Protein tyrosine kinase
NM_009050.2 → NP_033076.2 proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor

See identical proteins and their annotated locations for NP_033076.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate segment in the 3' coding region, compared to variant 4. The resulting protein (isoform a) has a longer, distinct C-terminus compared to isoform c. This isoform is also known as Ret51.

Source sequence(s)

AC135861, AC156396, BC059012

Consensus CDS

CCDS20470.1

UniProtKB/Swiss-Prot

P35546, Q8BQ34, Q9QXH9

Related

ENSMUSP00000032201.6, ENSMUST00000032201.8

Conserved Domains (5) summary

cd05045
Location:724 → 1013

PTKc_RET; Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein

pfam00028
Location:173 → 262

Cadherin; Cadherin domain

pfam17756
Location:29 → 154

RET_CLD1; RET Cadherin like domain 1

pfam17812
Location:266 → 380

RET_CLD3; RET Cadherin like domain 3

pfam17813
Location:409 → 508

RET_CLD4; RET Cadherin like domain 4