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    PCSK9 proprotein convertase subtilisin/kexin type 9 [ Sus scrofa (pig) ]

    Gene ID: 100620501, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PCSK9provided by VGNC
    Official Full Name
    proprotein convertase subtilisin/kexin type 9provided by VGNC
    Primary source
    VGNC:VGNC:91234
    See related
    Ensembl:ENSSSCG00000025020
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Biased expression in liver (RPKM 35.2) and mixtures (RPKM 12.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See PCSK9 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 6 NC_010448.4 (157388370..157409620, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 6 NC_010448.3 (145451983..145473336, complement)

    Chromosome 6 - NC_010448.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110261421 Neighboring gene ubiquitin specific peptidase 24 Neighboring gene barttin CLCNK type accessory subunit beta Neighboring gene transmembrane protein 61

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Porcine Reproductive and Respiratory Syndrome Virus Antagonizes PCSK9's Antiviral Effect via Nsp11 Endoribonuclease Activity. Zhang Y, et al. Viruses, 2020 Jun 17. PMID 32560445, Free PMC Article
    2. Peripheral vascular atherosclerosis in a novel PCSK9 gain-of-function mutant Ossabaw miniature pig model. Hedayat AF, et al. Transl Res, 2018 Feb. PMID 29175268, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Porcine Reproductive and Respiratory Syndrome Virus Antagonizes PCSK9's Antiviral Effect via Nsp11 Endoribonuclease Activity.
      Title: Porcine Reproductive and Respiratory Syndrome Virus Antagonizes PCSK9's Antiviral Effect via Nsp11 Endoribonuclease Activity.
    2. the PCSK9-gain-of-function mutation induces rapid development of atherosclerosis in peripheral vessels of Ossabaw pigs, which is exacerbated by a high-cholesterol diet.
      Title: Peripheral vascular atherosclerosis in a novel PCSK9 gain-of-function mutant Ossabaw miniature pig model.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LOW QUALITY PROTEIN: proprotein convertase subtilisin/kexin type 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010448.4 Reference Sscrofa11.1 Primary Assembly

      Range
      157388370..157409620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005653438.3 → XP_005653495.2  LOW QUALITY PROTEIN: proprotein convertase subtilisin/kexin type 9

      UniProtKB/TrEMBL
      A0A8D1DPA1
      Related
      ENSSSCP00000023105.3, ENSSSCT00000029382.4
      Conserved Domains (3) summary
      cd04077
      Location:154 → 432
      Peptidases_S8_PCSK9_ProteinaseK_like; Peptidase S8 family domain in ProteinaseK-like proteins
      pfam05922
      Location:75 → 147
      Inhibitor_I9; Peptidase inhibitor I9
      cd16839
      Location:463 → 694
      PCSK9_C-CRD; proprotein convertase subtilisin/kexin type 9, C-terminal cysteine-rich domain (CRD)
    Nucleotide Protein
    Heading Accession and Version

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