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    Nmnat1 nicotinamide nucleotide adenylyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298653, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Nmnat1provided by RGD
    Official Full Name
    nicotinamide nucleotide adenylyltransferase 1provided by RGD
    Primary source
    RGD:1310996
    See related
    EnsemblRapid:ENSRNOG00000015962 AllianceGenome:RGD:1310996
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity; nicotinamide-nucleotide adenylyltransferase activity; and nicotinate-nucleotide adenylyltransferase activity. Involved in negative regulation of apoptotic DNA fragmentation; negative regulation of neuron apoptotic process; and positive regulation of MAPK cascade. Located in cytoplasm and nucleus. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 9 and spondyloepiphyseal dysplasia, sensorineural hearing loss, intellectual developmental disorder, and Leber congenital amaurosis. Orthologous to human NMNAT1 (nicotinamide nucleotide adenylyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 38.3), Adrenal (RPKM 37.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nmnat1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (165193301..165211213, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (159910242..159928201, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (166409460..166430291, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ubiquitination factor E4B Neighboring gene retinol binding protein 7 Neighboring gene uncharacterized LOC134479087 Neighboring gene leucine zipper and CTNNBIP1 domain containing Neighboring gene catenin, beta-interacting protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nmnat 1: a Security Guard of Retinal Ganglion Cells (RGCs) in Response to High Glucose Stress. Zhou RM, et al. Cell Physiol Biochem, 2016. PMID 27184051
    2. Chemical genetic-mediated spatial regulation of protein expression in neurons reveals an axonal function for wld(s). Cohen MS, et al. Chem Biol, 2012 Feb 24. PMID 22365601, Free PMC Article
    3. The slow Wallerian degeneration gene in vivo protects motor axons but not their cell bodies after avulsion and neonatal axotomy. Adalbert R, et al. Eur J Neurosci, 2006 Oct. PMID 17074042
    4. The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model. Beirowski B, et al. Eur J Neurosci, 2008 Sep. PMID 18783366
    5. Molecular cloning, chromosomal localization, tissue mRNA levels, bacterial expression, and enzymatic properties of human NMN adenylyltransferase. Emanuelli M, et al. J Biol Chem, 2001 Jan 5. PMID 11027696

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nmnat1 protects Retinal Ganglion Cells against high glucose-induced injury via p38-MAPK signaling pathway.
      Title: Nmnat 1: a Security Guard of Retinal Ganglion Cells (RGCs) in Response to High Glucose Stress.
    2. The axonal pool of Wld(S) is necessary for protection from axon degeneration.
      Title: Chemical genetic-mediated spatial regulation of protein expression in neurons reveals an axonal function for wld(s).
    3. Data show that Wld(S) delays optic nerve (ON)axonal degeneration in experimental rat glaucoma for at least 2 weeks, especially in proximal ON where wild-type axons are most severely affected.
      Title: The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model.
    4. The slow Wallerian degeneration gene (Wld(S)) mutation delays Wallerian degeneration and axon pathology for several weeks in rats.
      Title: The slow Wallerian degeneration gene in vivo protects motor axons but not their cell bodies after avulsion and neonatal axotomy.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156478

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nicotinamide-nucleotide adenylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nicotinamide-nucleotide adenylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nicotinate-nucleotide adenylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nicotinate-nucleotide adenylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein ADP-ribosyltransferase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP generation from poly-ADP-D-ribose ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in NAD biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within NAD biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in NAD biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic DNA fragmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
    Names
    nicotinamide mononucleotide adenylyl transferase 1
    NP_001032645.2
    XP_006239491.1
    XP_017448800.1
    XP_038965628.1
    XP_038965630.1
    XP_038965632.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037556.2 → NP_001032645.2  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

      See identical proteins and their annotated locations for NP_001032645.2

      Status: PROVISIONAL

      Source sequence(s)
      BC127446
      UniProtKB/TrEMBL
      A0JPJ0, E9PSK8, Q32WF6
      Related
      ENSRNOP00000041982.6, ENSRNOT00000048914.6
      Conserved Domains (1) summary
      cd09286
      Location:9 → 255
      NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      165193301..165211213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109700.2 → XP_038965628.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ANE3
      Related
      ENSRNOP00000076779.2, ENSRNOT00000113614.2
      Conserved Domains (1) summary
      cd09286
      Location:36 → 282
      NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic

    2. XM_039109704.2 → XP_038965632.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 isoform X5

      Conserved Domains (1) summary
      cl00015
      Location:40 → 139
      nt_trans; nucleotidyl transferase superfamily

    3. XM_006239429.5 → XP_006239491.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006239491.1

      UniProtKB/TrEMBL
      A0A8I5ZK56, A0A8I5ZV91
      Related
      ENSRNOP00000083340.1, ENSRNOT00000105546.2
      Conserved Domains (1) summary
      cd09286
      Location:40 → 286
      NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic

    4. XM_017593311.3 → XP_017448800.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 isoform X3

      UniProtKB/TrEMBL
      A0JPJ0, E9PSK8, Q32WF6
      Conserved Domains (1) summary
      cd09286
      Location:9 → 255
      NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic

    5. XM_039109702.2 → XP_038965630.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 isoform X4

      Conserved Domains (1) summary
      cl00015
      Location:1 → 187
      nt_trans; nucleotidyl transferase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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