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    Syne1 spectrin repeat containing, nuclear envelope 1 [ Mus musculus (house mouse) ]

    Gene ID: 64009, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Syne1provided by MGI
    Official Full Name
    spectrin repeat containing, nuclear envelope 1provided by MGI
    Primary source
    MGI:MGI:1927152
    See related
    Ensembl:ENSMUSG00000096054 AllianceGenome:MGI:1927152
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    8B; CPG2; KASH1; Myne1; myne-1; mKIAA1756; A330049M09Rik; C130039F11Rik
    Summary
    Enables actin filament binding activity and protein homodimerization activity. Involved in centrosome localization and regulation of cilium assembly. Acts upstream of or within nuclear migration. Located in nuclear envelope. Is expressed in several structures, including alimentary system; ear; genitourinary system; musculoskeletal system; and nervous system. Used to study Emery-Dreifuss muscular dystrophy. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita (multiple); bipolar disorder; cerebellar ataxia (multiple); and muscular dystrophy (multiple). Orthologous to human SYNE1 (spectrin repeat containing nuclear envelope protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 19.1), frontal lobe adult (RPKM 7.9) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Syne1 in Genome Data Viewer
    Location:
    10 A1; 10 2.01 cM
    Exon count:
    152
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (4970192..5501013, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (5020192..5550692, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25622 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:5733988-5734171 Neighboring gene STARR-seq mESC enhancer starr_25621 Neighboring gene STARR-seq mESC enhancer starr_25620 Neighboring gene glutathione S-transferase, pi 1 pseudogene Neighboring gene estrogen receptor 1 (alpha) Neighboring gene STARR-seq mESC enhancer starr_25619 Neighboring gene STARR-seq mESC enhancer starr_25618 Neighboring gene STARR-seq mESC enhancer starr_25616 Neighboring gene STARR-seq mESC enhancer starr_25614 Neighboring gene STARR-seq mESC enhancer starr_25613 Neighboring gene STARR-seq mESC enhancer starr_25612 Neighboring gene STARR-positive B cell enhancer ABC_E2314 Neighboring gene STARR-seq mESC enhancer starr_25609 Neighboring gene STARR-seq mESC enhancer starr_25607 Neighboring gene STARR-seq mESC enhancer starr_25605 Neighboring gene STARR-seq mESC enhancer starr_25604 Neighboring gene predicted gene, 51757 Neighboring gene predicted gene, 23573 Neighboring gene STARR-seq mESC enhancer starr_25603 Neighboring gene predicted gene, 40594 Neighboring gene STARR-seq mESC enhancer starr_25602 Neighboring gene STARR-seq mESC enhancer starr_25600 Neighboring gene predicted gene, 51758 Neighboring gene STARR-positive B cell enhancer mm9_chr10:4746082-4746383 Neighboring gene myc target 1 Neighboring gene vasoactive intestinal polypeptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Increased expression of Syne1/nesprin-1 facilitates nuclear envelope structure changes in embryonic stem cell differentiation. Smith ER, et al. Dev Dyn, 2011 Oct. PMID 21932307, Free PMC Article
    2. A variant of Nesprin1 giant devoid of KASH domain underlies the molecular etiology of autosomal recessive cerebellar ataxia type I. Razafsky D, et al. Neurobiol Dis, 2015 Jun. PMID 25843669, Free PMC Article
    3. Nuclear alignment in myotubes requires centrosome proteins recruited by nesprin-1. Espigat-Georger A, et al. J Cell Sci, 2016 Nov 15. PMID 27802164
    4. [Effect of nesprin-1 in the differentiation of mouse embryonic stem cells into cardiomyocytes]. Gao F, et al. Sichuan Da Xue Xue Bao Yi Xue Ban, 2012 Mar. PMID 22650022
    5. The KASH-containing isoform of Nesprin1 giant associates with ciliary rootlets of ependymal cells. Potter C, et al. Neurobiol Dis, 2018 Jul. PMID 29630990, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In agreement with the association of Nesprin1alpha with photoreceptor ciliary rootlets and the functional interaction between rootletin and Nesprin1 in fibroblasts, the authors demonstrate that multiple isoforms of Nesprin1 are integral components of ciliary rootlets of multiciliated ependymal and tracheal cells.
      Title: Multiple Isoforms of Nesprin1 Are Integral Components of Ciliary Rootlets.
    2. Nesprin-1alpha recruits Akap450 to the nuclear envelope (NE)independently of kinesin and that Akap450, but not other centrosomal proteins, is required for microtubule nucleation from the NE.
      Title: Nesprin-1α-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells.
    3. Nesprin 1alpha2, which lacks actin-binding domains, was crucial for postnatal viability, nuclear positioning, and skeletal muscle function.
      Title: Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle.
    4. the positioning of nuclei requires PCM-1, a protein of the centrosome that relocalizes to the nuclear envelope at the onset of differentiation in a manner that is dependent on the presence of nesprin-1.
      Title: Nuclear alignment in myotubes requires centrosome proteins recruited by nesprin-1.
    5. Results suggest that the loss of function of KASH-LESS variant of Nesprin1 giant resulting from Nesprin1 nonsense mutations underlies the molecular etiology of autosomal recessive cerebellar ataxia Type I.
      Title: A variant of Nesprin1 giant devoid of KASH domain underlies the molecular etiology of autosomal recessive cerebellar ataxia type I.
    6. Disruption of both nesprin 1 and desmin results in decreased lifespan, body weight and muscle strength.
      Title: Disruption of both nesprin 1 and desmin results in nuclear anchorage defects and fibrosis in skeletal muscle.
    7. nesprin-dependent recruitment of kinesin-1 to the nuclear envelope through the interaction of a conserved LEWD motif with kinesin light chain might be a general mechanism for cell-type-specific nuclear positioning during development.
      Title: Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.
    8. a role for Nesprin-1 in the DNA damage response pathway
      Title: Nesprin-1 role in DNA damage response.
    9. Loss of Nesprin 1 or 2, or both, led to impairment of gene expression changes in response to biomechanical stimuli. These data suggest a model whereby biomechanical signals are communicated from proteins of the outer nuclear membrane
      Title: Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.
    10. Nesprin-1 played important roles in mouse embryonic stem cell differentiation into cardiomyocytes.
      Title: [Effect of nesprin-1 in the differentiation of mouse embryonic stem cells into cardiomyocytes].
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1756, MGC62825

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin filament binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lamin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centrosome localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear matrix anchoring at nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of meiotic nuclear membrane microtubule tethering complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope TAS
    Traceable Author Statement
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcomere ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nesprin-1
    Names
    KASH domain-containing protein 1
    enaptin
    enaptin165
    myocyte nuclear envelope protein 1
    nesprin 1
    nuclear envelope spectrin repeat protein 1
    synaptic nuclear envelope 1
    synaptic nuclear envelope protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079686.2 → NP_001073154.1  nesprin-1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and lacks a large portion of the 5' coding region found in variant 4. These differences result in the use of an alternate start codon, compared to variant 4. The encoded isoform (3) is shorter and has distinct N-terminus compared to isoform 4.
      Source sequence(s)
      AC156393, AC161829, AC162381
      UniProtKB/Swiss-Prot
      Q6ZWR6
      UniProtKB/TrEMBL
      Q6PI72
      Conserved Domains (4) summary
      COG4942
      Location:292 → 549
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:2216 → 2426
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam10541
      Location:2953 → 3009
      KASH; Nuclear envelope localization domain
      cl02488
      Location:1377 → 1565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    2. NM_001347711.2 → NP_001334640.1  nesprin-1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (4).
      Source sequence(s)
      AC156392, AC156393, AC159748, AC161829, AC162381, AC162385
      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

    3. NM_001347732.2 → NP_001334661.1  nesprin-1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and has multiple difference in the coding region compared variant 4. These differences result in the use of an alternate start codon, compared to variant 4. The encoded isoform (5) has a unique N-terminus and is shorter than isoform 4.
      Source sequence(s)
      AC156392, AC156393, AC157020, AC159748, AC161829, AC162381, AC162385
      Consensus CDS
      CCDS87951.1
      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      UniProtKB/TrEMBL
      A0A1L1STC6
      Related
      ENSMUSP00000150262.2, ENSMUST00000215295.2

    4. NM_022027.3 → NP_071310.2  nesprin-1 isoform 2

      See identical proteins and their annotated locations for NP_071310.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks a large portion of the 5' coding region compared to variant 4. These differences result in the use of an alternate start codon, compared to variant 4. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 4.
      Source sequence(s)
      AC156393, AC161829
      Consensus CDS
      CCDS56679.1
      UniProtKB/TrEMBL
      Q0VGB8, Q7TQH5
      Related
      ENSMUSP00000093587.4, ENSMUST00000095899.5
      Conserved Domains (2) summary
      cd00176
      Location:155 → 365
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam10541
      Location:892 → 948
      KASH; Nuclear envelope localization domain

    5. NM_153399.3 → NP_700448.2  nesprin-1 isoform 1

      See identical proteins and their annotated locations for NP_700448.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in both UTRs and has multiple differences in the coding region compared to variant 4. These differences result in the use of an alternate start codon, compared to variant 4. The encoded isoform (1) is shorter and has distinct N- and C-termini compared to isoform 4.
      Source sequence(s)
      AC157020, AC159748, AC162385
      Consensus CDS
      CCDS56680.1
      UniProtKB/TrEMBL
      Q6ZWR1, Q6ZWR5, Q80T95
      Related
      ENSMUSP00000039440.6, ENSMUST00000041639.7
      Conserved Domains (3) summary
      cd00014
      Location:28 → 141
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00307
      Location:187 → 285
      CH; Calponin homology (CH) domain
      cl02488
      Location:842 → 1006
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      4970192..5501013 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155919.1 → XP_036011812.1  nesprin-1 isoform X9

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (9) summary
      COG0419
      Location:3792 → 4354
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:2856 → 3639
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:6055 → 6313
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:7980 → 8190
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4944 → 5779
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:8740 → 8796
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 136
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:175 → 283
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:4326 → 4542
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    2. XM_036155938.1 → XP_036011831.1  nesprin-1 isoform X29

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (9) summary
      COG0419
      Location:3808 → 4370
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:2872 → 3655
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:6067 → 6324
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:7991 → 8201
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4960 → 5795
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:8728 → 8784
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 136
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:175 → 283
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:4342 → 4558
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    3. XM_036155916.1 → XP_036011809.1  nesprin-1 isoform X5

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (9) summary
      COG0419
      Location:3808 → 4370
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:2872 → 3655
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:6071 → 6329
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:7996 → 8206
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4960 → 5795
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:8756 → 8812
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 136
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:175 → 283
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:4342 → 4558
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    4. XM_036155917.1 → XP_036011810.1  nesprin-1 isoform X6

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (9) summary
      COG0419
      Location:3799 → 4361
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:2863 → 3646
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:6062 → 6320
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:7987 → 8197
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4951 → 5786
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:8747 → 8803
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:4333 → 4549
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    5. XM_036155924.1 → XP_036011817.1  nesprin-1 isoform X16

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (8) summary
      COG0419
      Location:3763 → 4325
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG4942
      Location:6026 → 6284
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:7951 → 8161
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4915 → 5750
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:8711 → 8767
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:4297 → 4513
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    6. XM_036155923.1 → XP_036011816.1  nesprin-1 isoform X15

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (9) summary
      COG0419
      Location:3815 → 4377
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:2879 → 3662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:6027 → 6285
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:7952 → 8162
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4967 → 5802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:8712 → 8768
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:4349 → 4565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    7. XM_036155921.1 → XP_036011814.1  nesprin-1 isoform X13

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (9) summary
      TIGR00618
      Location:5631 → 6278
      sbcc; exonuclease SbcC
      COG0419
      Location:3815 → 4377
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:2879 → 3662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:7956 → 8166
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4967 → 5802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:8716 → 8772
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:4349 → 4565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    8. XM_036155920.1 → XP_036011813.1  nesprin-1 isoform X11

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (9) summary
      COG0419
      Location:3815 → 4377
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:2879 → 3662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:6074 → 6331
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:7998 → 8208
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4967 → 5802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:8735 → 8791
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:4349 → 4565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    9. XM_036155915.1 → XP_036011808.1  nesprin-1 isoform X4

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (9) summary
      COG0419
      Location:3815 → 4377
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:2879 → 3662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:6074 → 6331
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:7998 → 8208
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4967 → 5802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:8758 → 8814
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:4349 → 4565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    10. XM_036155914.1 → XP_036011807.1  nesprin-1 isoform X3

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (9) summary
      COG0419
      Location:3815 → 4377
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:2879 → 3662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:6074 → 6332
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:7999 → 8209
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4967 → 5802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:8759 → 8815
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:4349 → 4565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    11. XM_036155932.1 → XP_036011825.1  nesprin-1 isoform X23

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (8) summary
      COG1196
      Location:2879 → 3662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:6078 → 6335
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:8002 → 8212
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4967 → 5802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:4143 → 4439
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:4349 → 4565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    12. XM_036155913.1 → XP_036011806.1  nesprin-1 isoform X2

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (9) summary
      COG0419
      Location:3815 → 4377
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:2879 → 3662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:6078 → 6335
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:8002 → 8212
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4967 → 5802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:8762 → 8818
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:4349 → 4565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    13. XM_036155931.1 → XP_036011824.1  nesprin-1 isoform X22

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (8) summary
      COG1196
      Location:2879 → 3662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:6078 → 6336
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:8003 → 8213
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4967 → 5802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:4143 → 4439
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:4349 → 4565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    14. XM_036155925.1 → XP_036011818.1  nesprin-1 isoform X17

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (9) summary
      COG0419
      Location:3815 → 4377
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:2879 → 3662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:6078 → 6336
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:8003 → 8213
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4967 → 5802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:8692 → 8748
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:4349 → 4565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    15. XM_036155922.1 → XP_036011815.1  nesprin-1 isoform X14

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (9) summary
      COG0419
      Location:3815 → 4377
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:2879 → 3662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:6078 → 6336
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:8003 → 8213
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4967 → 5802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:8715 → 8771
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:4349 → 4565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    16. XM_036155927.1 → XP_036011820.1  nesprin-1 isoform X19

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (8) summary
      COG1196
      Location:2879 → 3662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:6078 → 6336
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:8003 → 8213
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4967 → 5802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:4143 → 4439
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:4349 → 4565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    17. XM_036155918.1 → XP_036011811.1  nesprin-1 isoform X8

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (9) summary
      COG0419
      Location:3815 → 4377
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:2879 → 3662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:6078 → 6336
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:8003 → 8213
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4967 → 5802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:8740 → 8796
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:4349 → 4565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    18. XM_036155926.1 → XP_036011819.1  nesprin-1 isoform X18

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (8) summary
      COG1196
      Location:2879 → 3662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:6078 → 6336
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:8003 → 8213
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4967 → 5802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:4143 → 4439
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:4349 → 4565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    19. XM_036155912.1 → XP_036011805.1  nesprin-1 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (9) summary
      COG0419
      Location:3815 → 4377
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:2879 → 3662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:6078 → 6336
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:8003 → 8213
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4967 → 5802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:8763 → 8819
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:4349 → 4565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    20. XM_036155928.1 → XP_036011821.1  nesprin-1 isoform X20

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (8) summary
      COG1196
      Location:2747 → 3530
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:5946 → 6204
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:7871 → 8081
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4835 → 5670
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:4011 → 4307
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam10541
      Location:8631 → 8687
      KASH; Nuclear envelope localization domain
      cd21243
      Location:50 → 158
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:4217 → 4433
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    21. XM_036155929.1 → XP_036011822.1  nesprin-1 isoform X21

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (8) summary
      COG1196
      Location:2731 → 3514
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:5930 → 6188
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:7855 → 8065
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4819 → 5654
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:3995 → 4291
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam10541
      Location:8615 → 8671
      KASH; Nuclear envelope localization domain
      cd21243
      Location:50 → 158
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:4201 → 4417
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    22. XM_011243086.3 → XP_011241388.1  nesprin-1 isoform X7

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (10) summary
      TIGR03785
      Location:1172 → 1244
      marine_sort_HK; proteobacterial dedicated sortase system histidine kinase
      COG0419
      Location:3799 → 4361
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:2863 → 3646
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:6062 → 6320
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:15 → 267
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:7987 → 8197
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4951 → 5786
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:5922 → 6099
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cl02488
      Location:4333 → 4549
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam10541
      Location:8747 → 8803
      KASH; Nuclear envelope localization domain

    23. XM_030245204.2 → XP_030101064.1  nesprin-1 isoform X12

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (10) summary
      TIGR03785
      Location:1156 → 1228
      marine_sort_HK; proteobacterial dedicated sortase system histidine kinase
      COG0419
      Location:3783 → 4345
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:2847 → 3630
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:6046 → 6304
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:15 → 267
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:7971 → 8181
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4935 → 5770
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:5906 → 6083
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cl02488
      Location:4317 → 4533
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam10541
      Location:8731 → 8787
      KASH; Nuclear envelope localization domain

    24. XM_036155930.1 → XP_036011823.1  nesprin-1 isoform X21

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (8) summary
      COG1196
      Location:2731 → 3514
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:5930 → 6188
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:7855 → 8065
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4819 → 5654
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:3995 → 4291
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam10541
      Location:8615 → 8671
      KASH; Nuclear envelope localization domain
      cd21243
      Location:50 → 158
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:4201 → 4417
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    25. XM_017314044.3 → XP_017169533.1  nesprin-1 isoform X10

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (10) summary
      TIGR03785
      Location:1163 → 1235
      marine_sort_HK; proteobacterial dedicated sortase system histidine kinase
      COG0419
      Location:3790 → 4352
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:2854 → 3637
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:6053 → 6311
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:15 → 274
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:7978 → 8188
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4942 → 5777
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:5913 → 6090
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cl02488
      Location:4324 → 4540
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam10541
      Location:8738 → 8794
      KASH; Nuclear envelope localization domain

    26. XM_036155933.1 → XP_036011826.1  nesprin-1 isoform X24

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (7) summary
      COG1196
      Location:2397 → 3180
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:5596 → 5854
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:7521 → 7731
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4485 → 5320
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:3661 → 3957
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam10541
      Location:8281 → 8337
      KASH; Nuclear envelope localization domain
      cl02488
      Location:3867 → 4083
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    27. XM_036155934.1 → XP_036011827.1  nesprin-1 isoform X25

      UniProtKB/Swiss-Prot
      Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
      Conserved Domains (7) summary
      COG1196
      Location:2373 → 3156
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:5572 → 5830
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:7497 → 7707
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4461 → 5296
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:3637 → 3933
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam10541
      Location:8257 → 8313
      KASH; Nuclear envelope localization domain
      cl02488
      Location:3843 → 4059
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    28. XM_036155937.1 → XP_036011830.1  nesprin-1 isoform X28

      UniProtKB/TrEMBL
      Q7TQH5
      Conserved Domains (2) summary
      cd00176
      Location:155 → 365
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam10541
      Location:915 → 971
      KASH; Nuclear envelope localization domain

    29. XM_036155935.1 → XP_036011828.1  nesprin-1 isoform X26

      Conserved Domains (7) summary
      COG1196
      Location:2879 → 3662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:6078 → 6266
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:3821 → 4011
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:4967 → 5802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:4349 → 4565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    30. XM_036155936.1 → XP_036011829.1  nesprin-1 isoform X27

      Conserved Domains (7) summary
      COG0419
      Location:3815 → 4377
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:2879 → 3651
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:3821 → 4036
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1167 → 2008
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd21241
      Location:24 → 143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182 → 290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:4349 → 4565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZWR6.2 GenPept UniProtKB/Swiss-Prot:Q6ZWR6

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