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    CPR1 F-box and associated interaction domains-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 826869, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CPR1
    Official Full Name
    F-box and associated interaction domains-containing protein
    Primary source
    TAIR:AT4G12560
    Locus tag
    AT4G12560
    See related
    Araport:AT4G12560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CONSTITUTIVE EXPRESSER OF PR GENES 1; CONSTITUTIVE EXPRESSER OF PR GENES 30; CPR30; T1P17.150; T1P17_150
    Summary
    Encodes CPR1 (Constitutive Expresser of PR Genes 1, also known as CPR30), a F-Box protein that functions as a negative regulator of defense response and targets resistance proteins.
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    Genomic context

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    See CPR1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    2
    Sequence:
    Chromosome: 4; NC_003075.7 (7441681..7443775)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Auxin-Induced in Root cultures 1 Neighboring gene miscRNA Neighboring gene ubiquitin protein ligase 5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The F-box protein CPR1/CPR30 negatively regulates R protein SNC1 accumulation. Gou M, et al. Plant J, 2012 Feb. PMID 21967323
    2. Stability of plant immune-receptor resistance proteins is controlled by SKP1-CULLIN1-F-box (SCF)-mediated protein degradation. Cheng YT, et al. Proc Natl Acad Sci U S A, 2011 Aug 30. PMID 21873230, Free PMC Article
    3. Plant TRAF Proteins Regulate NLR Immune Receptor Turnover. Huang S, et al. Cell Host Microbe, 2016 Feb 10. PMID 26867179
    4. An F-box gene, CPR30, functions as a negative regulator of the defense response in Arabidopsis. Gou M, et al. Plant J, 2009 Dec. PMID 19682297
    5. A comprehensive analysis of interaction and localization of Arabidopsis SKP1-like (ASK) and F-box (FBX) proteins. Kuroda H, et al. PLoS One, 2012. PMID 23166809, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CPR1/CPR30 is a negative regulator of the R protein SNC1. Degradation of SNC1 controls plant immunity.
      Title: The F-box protein CPR1/CPR30 negatively regulates R protein SNC1 accumulation.
    2. CPR30 is a novel negative regulator that regulates both SA-dependent and SA-independent defense signaling in Arabidopsis.
      Title: An F-box gene, CPR30, functions as a negative regulator of the defense response in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001084908.2
    NM_001340790.1
    NM_117326.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    F-box and associated interaction domains-containing protein
    NP_001078377.1
    • CONSTITUTIVE EXPRESSER OF PR GENES 30 (CPR30); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: negative regulation of defense response; LOCATED IN: nucleus, cytoplasm; EXPRESSED IN: 8 plant structures; CONTAINS InterPro DOMAIN/s: F-box domain, cyclin-like (InterPro:IPR001810), F-box domain, Skp2-like (InterPro:IPR022364), F-box associated domain, type 1 (InterPro:IPR006527), F-box associated interaction domain (InterPro:IPR017451); BEST Arabidopsis thaliana protein match is: F-box associated ubiquitination effector family protein (TAIR:AT4G22390.1); Has 1743 Blast hits to 1730 proteins in 49 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 1741; Viruses - 0; Other Eukaryotes - 2 (source: NCBI BLink).
    NP_192993.2
    • CONSTITUTIVE EXPRESSER OF PR GENES 30 (CPR30); CONTAINS InterPro DOMAIN/s: F-box domain, cyclin-like (InterPro:IPR001810), F-box domain, Skp2-like (InterPro:IPR022364), F-box associated domain, type 1 (InterPro:IPR006527), F-box associated interaction domain (InterPro:IPR017451); BEST Arabidopsis thaliana protein match is: F-box associated ubiquitination effector family protein (TAIR:AT4G22390.1); Has 1743 Blast hits to 1730 proteins in 49 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 1741; Viruses - 0; Other Eukaryotes - 2 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      7441681..7443775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001084908.2 → NP_001078377.1  F-box and associated interaction domains-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078377.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WNU7, Q9SU30
      UniProtKB/TrEMBL
      A0A178UW44, A0A5S9XSG1, A0A654FNK1
      Conserved Domains (2) summary
      smart00256
      Location:4 → 40
      FBOX; A Receptor for Ubiquitination Targets
      cl23987
      Location:96 → 329
      FBA_1; F-box associated

    2. NM_001340790.1 → NP_001328191.1  F-box and associated interaction domains-containing protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WNU7, Q9SU30
      UniProtKB/TrEMBL
      A0A178UW44, A0A5S9XSG1, A0A654FNK1
      Conserved Domains (2) summary
      smart00256
      Location:4 → 40
      FBOX; A Receptor for Ubiquitination Targets
      cl23987
      Location:96 → 329
      FBA_1; F-box associated

    3. NM_117326.4 → NP_192993.2  F-box and associated interaction domains-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192993.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WNU7, Q9SU30
      UniProtKB/TrEMBL
      A0A178UW44, A0A5S9XSG1, A0A654FNK1
      Conserved Domains (2) summary
      smart00256
      Location:4 → 40
      FBOX; A Receptor for Ubiquitination Targets
      cl23987
      Location:96 → 329
      FBA_1; F-box associated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SU30.2

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