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    MYH10 myosin heavy chain 10 [ Homo sapiens (human) ]

    Gene ID: 4628, updated on 3-Nov-2024

    Summary

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    Official Symbol
    MYH10provided by HGNC
    Official Full Name
    myosin heavy chain 10provided by HGNC
    Primary source
    HGNC:HGNC:7568
    See related
    Ensembl:ENSG00000133026 MIM:160776; AllianceGenome:HGNC:7568
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NMMHCB; NMMHC-IIB
    Summary
    This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
    Expression
    Broad expression in lung (RPKM 33.9), placenta (RPKM 28.3) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MYH10 in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (8474212..8630725, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (8380372..8536822, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8377530..8534043, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:8285969-8286686 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8286687-8287404 Neighboring gene Sharpr-MPRA regulatory region 12124 Neighboring gene ribosomal protein L26 Neighboring gene Sharpr-MPRA regulatory regions 4336 and 10869 Neighboring gene ring finger protein 222 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8182 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8183 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8184 Neighboring gene MPRA-validated peak2716 silencer Neighboring gene nudE neurodevelopment protein 1 like 1 Neighboring gene MPRA-validated peak2717 silencer Neighboring gene Sharpr-MPRA regulatory region 9669 Neighboring gene uncharacterized LOC107987245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8390687-8391187 Neighboring gene Sharpr-MPRA regulatory region 1803 Neighboring gene uncharacterized LOC102724262 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:8416542-8417741 Neighboring gene RNA, U7 small nuclear 43 pseudogene Neighboring gene Sharpr-MPRA regulatory region 10362 Neighboring gene Sharpr-MPRA regulatory region 2377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11699 Neighboring gene ribosomal protein S26 pseudogene 53 Neighboring gene peptidylprolyl isomerase A pseudogene 52 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:8532416-8533194 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:8533195-8533972 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:8533973-8534750 Neighboring gene Sharpr-MPRA regulatory region 9864 Neighboring gene uncharacterized LOC105371525 Neighboring gene VISTA enhancer hs2548 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8599868-8600378 Neighboring gene Sharpr-MPRA regulatory region 493 Neighboring gene uncharacterized LOC105371526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8642150-8642650 Neighboring gene coiled-coil domain containing 42

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Down-regulation of MYH10 driven by chromosome 17p13.1 deletion promotes hepatocellular carcinoma metastasis through activation of the EGFR pathway. Jin Q, et al. J Cell Mol Med, 2021 Dec. PMID 34738311, Free PMC Article
    2. Enucleation of human erythroblasts involves non-muscle myosin IIB. Ubukawa K, et al. Blood, 2012 Jan 26. PMID 22049517, Free PMC Article
    3. Myeloid lineage cells inhibit neurite outgrowth through a myosin II-dependent mechanism. Pool M, et al. J Neuroimmunol, 2011 Aug 15. PMID 21737147
    4. MYH10 protein expression in platelets as a biomarker of RUNX1 and FLI1 alterations. Antony-Debré I, et al. Blood, 2012 Sep 27. PMID 22677128
    5. Heterozygous variants in MYH10 associated with neurodevelopmental disorders and congenital anomalies with evidence for primary cilia-dependent defects in Hedgehog signaling. Holtz AM, et al. Genet Med, 2022 Oct. PMID 35980381, Free PMC Article

    See all (285) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spindle cell neoplasms with novel LTK fusion - Expanding the spectrum of kinase fusion-positive soft tissue tumors.
      Title: Spindle cell neoplasms with novel LTK fusion - Expanding the spectrum of kinase fusion-positive soft tissue tumors.
    2. Mechanisms underlying Myosin 10's contribution to the maintenance of mitotic spindle bipolarity.
      Title: Mechanisms underlying Myosin 10's contribution to the maintenance of mitotic spindle bipolarity.
    3. MYH10 Combines with MYH9 to Recruit USP45 by Deubiquitinating Snail and Promotes Serous Ovarian Cancer Carcinogenesis, Progression, and Cisplatin Resistance.
      Title: MYH10 Combines with MYH9 to Recruit USP45 by Deubiquitinating Snail and Promotes Serous Ovarian Cancer Carcinogenesis, Progression, and Cisplatin Resistance.
    4. Heterozygous variants in MYH10 associated with neurodevelopmental disorders and congenital anomalies with evidence for primary cilia-dependent defects in Hedgehog signaling.
      Title: Heterozygous variants in MYH10 associated with neurodevelopmental disorders and congenital anomalies with evidence for primary cilia-dependent defects in Hedgehog signaling.
    5. Down-regulation of MYH10 driven by chromosome 17p13.1 deletion promotes hepatocellular carcinoma metastasis through activation of the EGFR pathway.
      Title: Down-regulation of MYH10 driven by chromosome 17p13.1 deletion promotes hepatocellular carcinoma metastasis through activation of the EGFR pathway.
    6. GATA1 pathogenic variants disrupt MYH10 silencing during megakaryopoiesis.
      Title: GATA1 pathogenic variants disrupt MYH10 silencing during megakaryopoiesis.
    7. The distinct roles of myosin IIA and IIB under compression stress in nucleus pulposus cells.
      Title: The distinct roles of myosin IIA and IIB under compression stress in nucleus pulposus cells.
    8. Network-based analysis reveals novel gene signatures in the peripheral blood of patients with sporadic nonsyndromic thoracic aortic aneurysm.
      Title: Network-based analysis reveals novel gene signatures in the peripheral blood of patients with sporadic nonsyndromic thoracic aortic aneurysm.
    9. survivin binds to non-muscle myosin II (NMII), regulating its filament assembly.
      Title: A direct interaction between survivin and myosin II is required for cytokinesis.
    10. Non-muscle myosin IIA (NMIIA) provides the mechanical tugging force necessary for cell-cell junction reinforcement and maintenance. Non-muscle myosin IIB (NMIIB) is involved in E-cadherin clustering, maintenance of a branched actin layer connecting E-cadherin complexes and perijunctional actin fibers in the biogenesis and integrity of adherens junctions.
      Title: Myosin II isoforms play distinct roles in adherens junction biogenesis.
    Submit: New GeneRIF Correction See all GeneRIFs (55)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2019-01-23)

    ClinGen Genome Curation Page
    Haploinsufficency

    Little evidence for dosage pathogenicity (Last evaluated 2019-01-23)

    ClinGen Genome Curation PagePubMed

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Interaction of HIV-1 Gag with myosin, heavy chain 10, non-muscle (MYH10) is identified in a series of six affinity purification/mass spectrometry screens PubMed
    Tat tat The centripetal and lateral movements of the HIV-1 Tat protein transduction domain are linked to the integrity of myosin II-based actin contraction in HeLa cells PubMed
    retropepsin gag-pol HIV-1 protease cleaves human myosin heavy chain in vitro PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC134913, MGC134914

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ADP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables RNA stem-loop binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to actin filament binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 5'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microfilament motor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to microfilament motor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament-based movement IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actomyosin structure organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mitotic cytokinesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in actomyosin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin II complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in myosin II filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of myosin complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in myosin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in postsynaptic actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic actin cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myosin-10
    Names
    myosin heavy chain, nonmuscle type B
    myosin, heavy chain 10, non-muscle
    myosin, heavy polypeptide 10, non-muscle
    nonmuscle myosin II heavy chain-B
    nonmuscle myosin heavy chain IIB

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042305.2 RefSeqGene

      Range
      5037..161538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001256012.3 → NP_001242941.1  myosin-10 isoform 1

      See identical proteins and their annotated locations for NP_001242941.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC011061, AC025518, AC026130
      Consensus CDS
      CCDS58515.1
      UniProtKB/Swiss-Prot
      P35580
      UniProtKB/TrEMBL
      G1UI33
      Related
      ENSP00000353590.4, ENST00000360416.8
      Conserved Domains (3) summary
      cd14920
      Location:99 → 802
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam01576
      Location:879 → 1959
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:33 → 72
      Myosin_N; Myosin N-terminal SH3-like domain

    2. NM_001256095.2 → NP_001243024.1  myosin-10 isoform 3

      See identical proteins and their annotated locations for NP_001243024.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC011061, AC025518, AC026130
      Consensus CDS
      CCDS73984.1
      UniProtKB/Swiss-Prot
      P35580
      Related
      ENSP00000369315.5, ENST00000379980.8
      Conserved Domains (3) summary
      cd14920
      Location:99 → 780
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam01576
      Location:857 → 1937
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:33 → 72
      Myosin_N; Myosin N-terminal SH3-like domain

    3. NM_001375266.1 → NP_001362195.1  myosin-10 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC011061, AC025518, AC026130
      Consensus CDS
      CCDS92256.1
      UniProtKB/TrEMBL
      A0A8I5KZ38
      Related
      ENSP00000510471.1, ENST00000692526.1
      Conserved Domains (3) summary
      cd14920
      Location:99 → 781
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam01576
      Location:858 → 1938
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:33 → 72
      Myosin_N; Myosin N-terminal SH3-like domain

    4. NM_005964.5 → NP_005955.3  myosin-10 isoform 2

      See identical proteins and their annotated locations for NP_005955.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in both the 5' and central coding regions, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC011061, AC025518, AC026130
      Consensus CDS
      CCDS11144.1
      UniProtKB/Swiss-Prot
      B2RWP9, D3DTS1, F8VTL3, P35580, Q12989, Q149N3, Q149N4, Q16087, Q4LE45, Q6PK16, Q9BWG0
      Related
      ENSP00000269243.4, ENST00000269243.8
      Conserved Domains (3) summary
      cd14920
      Location:99 → 771
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam01576
      Location:848 → 1928
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:33 → 72
      Myosin_N; Myosin N-terminal SH3-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      8474212..8630725 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      8380372..8536822 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35580.3 GenPept UniProtKB/Swiss-Prot:P35580

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