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    Gk5 glycerol kinase 5 [ Mus musculus (house mouse) ]

    Gene ID: 235533, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gk5provided by MGI
    Official Full Name
    glycerol kinase 5provided by MGI
    Primary source
    MGI:MGI:2443336
    See related
    Ensembl:ENSMUSG00000041440 AllianceGenome:MGI:2443336
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C330018K18Rik; G630067D24Rik
    Summary
    Enables glycerol kinase activity. Involved in glycerol-3-phosphate biosynthetic process. Located in cytoplasm. Is expressed in olfactory epithelium and submandibular gland primordium. Orthologous to human GK5 (glycerol kinase 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 2.4), limb E14.5 (RPKM 1.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gk5 in Genome Data Viewer
    Location:
    9 E3.3; 9 50.31 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (96001379..96066680)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (96119344..96184627)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ataxia telangiectasia and Rad3 related Neighboring gene STARR-positive B cell enhancer ABC_E3852 Neighboring gene predicted gene, 16794 Neighboring gene STARR-positive B cell enhancer ABC_E8307 Neighboring gene STARR-seq mESC enhancer starr_24940 Neighboring gene 5'-3' exoribonuclease 1 Neighboring gene STARR-seq mESC enhancer starr_24941 Neighboring gene STARR-seq mESC enhancer starr_24942 Neighboring gene STARR-positive B cell enhancer ABC_E8308 Neighboring gene STARR-seq mESC enhancer starr_24949 Neighboring gene transcription factor Dp 2 Neighboring gene predicted gene, 39408 Neighboring gene ATPase, Na+/K+ transporting, beta 3 polypeptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5. Zhang D, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28607088, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycerol catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerol-3-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerol-3-phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in triglyceride metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glycerol kinase 5; putative glycerol kinase 5
    Names
    ATP:glycerol 3-phosphotransferase 5
    GK 5
    glycerokinase 5
    glycerol kinase 5 (putative)
    NP_001355808.1
    NP_796326.1
    XP_006511195.1
    XP_006511196.1
    XP_006511197.1
    XP_036010805.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368879.1 → NP_001355808.1  glycerol kinase 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC166175
      Consensus CDS
      CCDS90642.1
      UniProtKB/Swiss-Prot
      Q14B67, Q3TK02, Q3TSE0, Q80VA9, Q8BX05
      Related
      ENSMUSP00000082313.6, ENSMUST00000085217.12
      Conserved Domains (1) summary
      cd07793
      Location:25 → 527
      FGGY_GK5_metazoa; metazoan glycerol kinase 5-like proteins; belongs to the FGGY family of carbohydrate kinases

    2. NM_177352.5 → NP_796326.1  glycerol kinase 5 isoform 2

      See identical proteins and their annotated locations for NP_796326.1

      Status: VALIDATED

      Source sequence(s)
      AC166175
      Consensus CDS
      CCDS52891.1
      UniProtKB/Swiss-Prot
      Q8BX05
      Related
      ENSMUSP00000112717.2, ENSMUST00000122383.3
      Conserved Domains (2) summary
      cd07793
      Location:25 → 512
      FGGY_GK5_metazoa; metazoan glycerol kinase 5-like proteins; belongs to the FGGY family of carbohydrate kinases
      COG0554
      Location:20 → 507
      GlpK; Glycerol kinase [Energy production and conversion]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      96001379..96066680
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154912.1 → XP_036010805.1  putative glycerol kinase 5 isoform X4

      Conserved Domains (1) summary
      cl17037
      Location:5 → 388
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    2. XM_006511132.4 → XP_006511195.1  putative glycerol kinase 5 isoform X1

      Conserved Domains (1) summary
      cl17037
      Location:1 → 437
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    3. XM_006511133.3 → XP_006511196.1  putative glycerol kinase 5 isoform X2

      Conserved Domains (1) summary
      cl17037
      Location:13 → 430
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    4. XM_006511134.2 → XP_006511197.1  putative glycerol kinase 5 isoform X3

      Conserved Domains (1) summary
      cl17037
      Location:15 → 424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RNA

    1. XR_004935424.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BX05.2 GenPept UniProtKB/Swiss-Prot:Q8BX05

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