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    LecRK-I.9 Concanavalin A-like lectin protein kinase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836152, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LecRK-I.9
    Official Full Name
    Concanavalin A-like lectin protein kinase family protein
    Primary source
    TAIR:AT5G60300
    Locus tag
    AT5G60300
    See related
    Araport:AT5G60300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Does not Respond to Nucleotides 1; DORN1; F15L12.17; F15L12_17; L-type lectin receptor kinase I.9; lectin receptor kinase I.9
    Summary
    Lectin Receptor Kinase involved in protein-protein interactions with RGD-containing proteins as potential ligands. Role in cell wall-plasma membrane adhesion. Involved in Phytophthora resistance.
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    Genomic context

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    See LecRK-I.9 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (24264488..24268029)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene uncharacterized protein Neighboring gene Concanavalin A-like lectin protein kinase family protein Neighboring gene Concanavalin A-like lectin protein kinase family protein Neighboring gene hydroxyacyl-thioester dehydratase type-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Plasma Membrane Purinoreceptor P2K1/DORN1 Is Essential in Stomatal Closure Evoked by Extracellular Diadenosine Tetraphosphate (Ap(4)A) in Arabidopsis thaliana. Dobrogojski J, et al. Int J Mol Sci, 2023 Nov 24. PMID 38069010, Free PMC Article
    2. S-acylation of P2K1 mediates extracellular ATP-induced immune signaling in Arabidopsis. Chen D, et al. Nat Commun, 2021 May 12. PMID 33980819, Free PMC Article
    3. Extracellular ATP elicits DORN1-mediated RBOHD phosphorylation to regulate stomatal aperture. Chen D, et al. Nat Commun, 2017 Dec 22. PMID 29273780, Free PMC Article
    4. Extracellular ATP Acts on Jasmonate Signaling to Reinforce Plant Defense. Tripathi D, et al. Plant Physiol, 2018 Jan. PMID 29180381, Free PMC Article
    5. X-ray crystallographic studies of the extracellular domain of the first plant ATP receptor, DORN1, and the orthologous protein from Camelina sativa. Li Z, et al. Acta Crystallogr F Struct Biol Commun, 2016 Oct 1. PMID 27710944, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Plasma Membrane Purinoreceptor P2K1/DORN1 Is Essential in Stomatal Closure Evoked by Extracellular Diadenosine Tetraphosphate (Ap4A) in Arabidopsis thaliana.
      Title: The Plasma Membrane Purinoreceptor P2K1/DORN1 Is Essential in Stomatal Closure Evoked by Extracellular Diadenosine Tetraphosphate (Ap(4)A) in Arabidopsis thaliana.
    2. S-acylation of P2K1 mediates extracellular ATP-induced immune signaling in Arabidopsis.
      Title: S-acylation of P2K1 mediates extracellular ATP-induced immune signaling in Arabidopsis.
    3. Mutation of DORN1 phosphorylation sites on RBOHD eliminates the ability of ATP to induce stomatal closure. The data implicate purinergic signaling via DORN1 in the control of stomatal aperture.
      Title: Extracellular ATP elicits DORN1-mediated RBOHD phosphorylation to regulate stomatal aperture.
    4. The role of LecRK-I.9 is discussed with regard to the potential molecular mechanisms linking jasmonic acid signalling to cell wall damage and/or extracellular ATP perception.
      Title: The Arabidopsis thaliana lectin receptor kinase LecRK-I.9 is required for full resistance to Pseudomonas syringae and affects jasmonate signalling.
    5. X-ray crystallographic studies of the extracellular domain of the first plant ATP receptor, DORN1, and the orthologous protein from Camelina sativa, have been presented.
      Title: X-ray crystallographic studies of the extracellular domain of the first plant ATP receptor, DORN1, and the orthologous protein from Camelina sativa.
    6. the genetic and biochemical evidence for the role of DORN1 in extracellular ATP signalling, placing this within the wider context of extracellular ATP signalling during plant stress responses. [Review]
      Title: Extracellular ATP, a danger signal, is recognized by DORN1 in Arabidopsis.
    7. LecRK-I.9 insertion mutants gain susceptibility to Phytophthora. Overexpression enhances resistance. Observations strongly suggest that LecRK-I.9 plays a role in disease resistance by stabilizing the cell wall-plasma membrane continuum. [LecRK-I.9]
      Title: The lectin receptor kinase LecRK-I.9 is a novel Phytophthora resistance component and a potential host target for a RXLR effector.
    8. DORN1 is essential for perception of extracellular ATP and likely plays a variety of roles in plant stress resistance.
      Title: Identification of a plant receptor for extracellular ATP.
    9. The lectin receptor kinase encoded by At5g60300 is involved in protein-protein interactions with RGD-containing proteins as potential ligands, and may play a structural and signaling role at the plant cell surfaces.
      Title: Lectin receptor kinases participate in protein-protein interactions to mediate plasma membrane-cell wall adhesions in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001085304.1
    NM_125423.3
    NM_180899.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to ATP IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to oomycetes IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to oomycetes IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to oomycetes IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within extracellular ATP signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within focal adhesion assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of jasmonic acid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Concanavalin A-like lectin protein kinase family protein
    NP_001078773.1
    • Concanavalin A-like lectin protein kinase family protein; FUNCTIONS IN: carbohydrate binding, kinase activity; INVOLVED IN: focal adhesion assembly; LOCATED IN: plasma membrane; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Legume lectin, beta chain (InterPro:IPR001220), Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Concanavalin A-like lectin/glucanase, subgroup (InterPro:IPR013320), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Concanavalin A-like lectin/glucanase (InterPro:IPR008985), Legume lectin, beta chain, Mn/Ca-binding site (InterPro:IPR019825); BEST Arabidopsis thaliana protein match is: Concanavalin A-like lectin protein kinase family protein (TAIR:AT3G45430.1); Has 112043 Blast hits to 110768 proteins in 4079 species: Archae - 91; Bacteria - 12985; Metazoa - 40494; Fungi - 8927; Plants - 33308; Viruses - 365; Other Eukaryotes - 15873 (source: NCBI BLink).
    NP_200838.1
    • Concanavalin A-like lectin protein kinase family protein; FUNCTIONS IN: carbohydrate binding, kinase activity; INVOLVED IN: focal adhesion assembly; LOCATED IN: plasma membrane; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Legume lectin, beta chain (InterPro:IPR001220), Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Concanavalin A-like lectin/glucanase, subgroup (InterPro:IPR013320), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Concanavalin A-like lectin/glucanase (InterPro:IPR008985), Legume lectin, beta chain, Mn/Ca-binding site (InterPro:IPR019825); BEST Arabidopsis thaliana protein match is: Concanavalin A-like lectin protein kinase family protein (TAIR:AT3G45430.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
    NP_851230.1
    • Concanavalin A-like lectin protein kinase family protein; FUNCTIONS IN: carbohydrate binding, kinase activity; INVOLVED IN: focal adhesion assembly; LOCATED IN: plasma membrane; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Legume lectin, beta chain (InterPro:IPR001220), Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Concanavalin A-like lectin/glucanase, subgroup (InterPro:IPR013320), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Concanavalin A-like lectin/glucanase (InterPro:IPR008985), Legume lectin, beta chain, Mn/Ca-binding site (InterPro:IPR019825); BEST Arabidopsis thaliana protein match is: Concanavalin A-like lectin protein kinase family protein (TAIR:AT3G45430.1); Has 112358 Blast hits to 111080 proteins in 4130 species: Archae - 91; Bacteria - 13102; Metazoa - 40494; Fungi - 9266; Plants - 33404; Viruses - 365; Other Eukaryotes - 15636 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      24264488..24268029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125423.3 → NP_200838.1  Concanavalin A-like lectin protein kinase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200838.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178U778, A0A654GCR0
      Conserved Domains (2) summary
      cd14066
      Location:350 → 614
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
      pfam00139
      Location:24 → 274
      Lectin_legB; Legume lectin domain

    2. NM_001085304.1 → NP_001078773.1  Concanavalin A-like lectin protein kinase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078773.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56XH0, Q93ZR5, Q9LSR8
      UniProtKB/TrEMBL
      A0A178U778
      Conserved Domains (3) summary
      smart00220
      Location:344 → 608
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14066
      Location:350 → 614
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
      pfam00139
      Location:24 → 274
      Lectin_legB; Legume lectin domain

    3. NM_180899.2 → NP_851230.1  Concanavalin A-like lectin protein kinase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851230.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178U778, A0A654GCR0
      Conserved Domains (2) summary
      cd14066
      Location:350 → 614
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
      pfam00139
      Location:24 → 274
      Lectin_legB; Legume lectin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LSR8.2

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