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    TMEM238L transmembrane protein 238 like [ Homo sapiens (human) ]

    Gene ID: 100289255, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TMEM238Lprovided by HGNC
    Official Full Name
    transmembrane protein 238 likeprovided by HGNC
    Primary source
    HGNC:HGNC:44356
    See related
    Ensembl:ENSG00000263429 AllianceGenome:HGNC:44356
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FORCP; LINC00675
    Summary
    Involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in stomach (RPKM 20.3), colon (RPKM 18.5) and 6 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TMEM238L in Genome Data Viewer
    Location:
    17p13.1-p12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (10794908..10804099, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (10702820..10712007, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (10698225..10707416, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:10600651-10601475 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:10616259-10616459 Neighboring gene ADP-ribose/CDP-alcohol diphosphatase, manganese dependent Neighboring gene transmembrane protein 220 Neighboring gene mago homolog 2, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:10632792-10633378 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:10633379-10633965 Neighboring gene TMEM220 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:10637362-10637547 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:10651975-10652524 Neighboring gene Sharpr-MPRA regulatory region 1671 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:10701903-10702404 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:10702405-10702904 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:10707035-10707820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:10710569-10711070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:10711071-10711570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:10718319-10718820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:10740215-10740716 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:10742413-10742637 Neighboring gene phosphoinositide interacting regulator of transient receptor potential channels Neighboring gene Sharpr-MPRA regulatory region 4925 Neighboring gene RNA, U6 small nuclear 1065, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. An Evolutionarily Conserved AU-Rich Element in the 3' Untranslated Region of a Transcript Misannotated as a Long Noncoding RNA Regulates RNA Stability. Dangelmaier EA, et al. Mol Cell Biol, 2022 Apr 21. PMID 35274990, Free PMC Article
    2. The lncRNA LINC00675 regulates cell proliferation, migration, and invasion by affecting Wnt/β-catenin signaling in cervical cancer. Ma S, et al. Biomed Pharmacother, 2018 Dec. PMID 30372871
    3. LINC00675 is a prognostic factor and regulates cell proliferation, migration and invasion in glioma. Li Z, et al. Biosci Rep, 2018 Oct 31. PMID 30061182, Free PMC Article
    4. Long non-coding RNA Linc00675 suppresses cell proliferation and metastasis in colorectal cancer via acting on miR-942 and Wnt/β-catenin signaling. Shan Z, et al. Biomed Pharmacother, 2018 May. PMID 29524886
    5. Long noncoding RNA LINC00675 enhances phosphorylation of vimentin on Ser83 to suppress gastric cancer progression. Zeng S, et al. Cancer Lett, 2018 Jan 1. PMID 29107103

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long noncoding RNA LINC00675 drives malignancy in acute myeloid leukemia via the miR-6809 -CDK6 axis.
      Title: Long noncoding RNA LINC00675 drives malignancy in acute myeloid leukemia via the miR-6809 -CDK6 axis.
    2. Investigation of Long Non-coding RNAs H19 and LINC00675 in Colorectal Cancers in Terms of Histopathological Features and Correlations With Plasma Markers.
      Title: Investigation of Long Non-coding RNAs H19 and LINC00675 in Colorectal Cancers in Terms of Histopathological Features and Correlations With Plasma Markers.
    3. Long non-coding RNA LINC00675 is associated with bladder cancer metastasis and patient survival.
      Title: Long non-coding RNA LINC00675 is associated with bladder cancer metastasis and patient survival.
    4. A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells.
      Title: A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells.
    5. LINC00675 acts as a tumor promoter in glioma progression.Levels of LINC00675 expression are increased in glioma tissues.
      Title: LINC00675 is a prognostic factor and regulates cell proliferation, migration and invasion in glioma.
    6. LINC00675 promoted cancer cell proliferation, migration, and invasion, and inhibit apoptosis likely by modulating the Wnt/beta-catenin pathway.
      Title: The lncRNA LINC00675 regulates cell proliferation, migration, and invasion by affecting Wnt/β-catenin signaling in cervical cancer.
    7. Overexpression of Linc00675 inhibited the proliferation, invasion and migration of colorectal cancer cells.
      Title: Long non-coding RNA Linc00675 suppresses cell proliferation and metastasis in colorectal cancer via acting on miR-942 and Wnt/β-catenin signaling.
    8. LINC00675 interacted with vimentin, a protein involved in cell metastasis, and enhanced its phosphorylation level on Ser83 to result in the collapse of vimentin filament in GC cells, thereby reducing cell metastasis.
      Title: Long noncoding RNA LINC00675 enhances phosphorylation of vimentin on Ser83 to suppress gastric cancer progression.
    9. Linc00675 may function as an oncogene during pancreatic ductal adenocarcinoma development, and its expression is an independent predictor of unfavorable prognosis in patients with PDAC.
      Title: Linc00675 is a novel marker of short survival and recurrence in patients with pancreatic ductal adenocarcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Homology

    Clone Names

    • FLJ21244

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transmembrane protein 238-like
    Names
    FOXA1-Regulated Conserved Small Protein
    long intergenic non-protein coding RNA 675
    putative transmembrane protein LOC100289255

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001388428.1 → NP_001375357.1  transmembrane protein 238-like

      Status: VALIDATED

      Source sequence(s)
      AC015908
      Consensus CDS
      CCDS92258.1
      UniProtKB/Swiss-Prot
      A0A1B0GVL6, A6NJY4
      Related
      ENSP00000490566.1, ENST00000581851.2
      Conserved Domains (1) summary
      pfam15125
      Location:44 → 76
      TMEM238; TMEM238 protein family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      10794908..10804099 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      10702820..10712007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NJY4.3 GenPept UniProtKB/Swiss-Prot:A6NJY4

    Gene LinkOut

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    Research Materials