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    MORN1 MORN repeat containing 1 [ Homo sapiens (human) ]

    Gene ID: 79906, updated on 17-Sep-2024

    Summary

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    Official Symbol
    MORN1provided by HGNC
    Official Full Name
    MORN repeat containing 1provided by HGNC
    Primary source
    HGNC:HGNC:25852
    See related
    Ensembl:ENSG00000116151 AllianceGenome:HGNC:25852
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in testis (RPKM 1.1), ovary (RPKM 0.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MORN1 in Genome Data Viewer
    Location:
    1p36.32
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (2321253..2391554, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (1757185..1830823, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (2252692..2322993, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2162329-2162990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 49 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 50 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2167621-2168533 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2168534-2169446 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2172187-2173099 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2174837-2175357 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2178827-2179753 Neighboring gene hESC enhancers GRCh37_chr1:2179754-2180679 and GRCh37_chr1:2180680-2181606 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:2186989-2188188 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2188191-2188788 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 51 Neighboring gene SKI proto-oncogene Neighboring gene Sharpr-MPRA regulatory region 2016 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2202895-2203857 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2204820-2205782 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2206746-2207708 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2209681-2210475 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2210476-2211270 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:2211723-2212922 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2214621-2215290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2215961-2216629 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 52 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2224323-2225233 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2225474-2225974 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2229335-2229846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2229847-2230358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 53 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2238093-2238726 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2244613-2245266 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 110 Neighboring gene uncharacterized LOC124903824 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2246747-2247500 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 109 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2253541-2254148 Neighboring gene small nuclear ribonucleoprotein polypeptide N pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr1:2306674-2306868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 54 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 55 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 56 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 112 Neighboring gene Sharpr-MPRA regulatory region 13804 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 114 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 113 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2340121-2340621 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2342650-2343230 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr1:2343231-2343811 to GRCh37_chr1:2344393-2344972 Neighboring gene retention in endoplasmic reticulum sorting receptor 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:2361610-2361787 Neighboring gene peroxisomal biogenesis factor 10 Neighboring gene phospholipase C eta 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2377030-2377864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2378700-2379534 Neighboring gene Sharpr-MPRA regulatory region 13638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2383066-2383714 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2383715-2384362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2423421-2423982 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:2430511-2431710

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Epigenome-wide gene-age interaction study reveals reversed effects of MORN1 DNA methylation on survival between young and elderly oral squamous cell carcinoma patients. Xu Z, et al. Front Oncol, 2022. PMID 35965572, Free PMC Article
    2. Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1. Li X, et al. NPJ Precis Oncol, 2021 Mar 19. PMID 33742100, Free PMC Article
    3. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
    4. A dual-activity topoisomerase complex regulates mRNA translation and turnover. Su S, et al. Nucleic Acids Res, 2022 Jul 8. PMID 35748872, Free PMC Article
    5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Fei T, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28611215, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ13941, FLJ46574

    General protein information

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    Preferred Names
    MORN repeat-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301060.2 → NP_001287989.1  MORN repeat-containing protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple 3' coding exons and contains an alternate 3' terminal exon, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AL513477, BC021704, BU741473
      Consensus CDS
      CCDS72688.1
      UniProtKB/Swiss-Prot
      Q5T089
      Related
      ENSP00000367790.3, ENST00000378529.7
      Conserved Domains (2) summary
      COG4642
      Location:59 → 191
      COG4642; Uncharacterized conserved protein [Function unknown]
      pfam02493
      Location:39 → 61
      MORN; MORN repeat

    2. NM_024848.3 → NP_079124.1  MORN repeat-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_079124.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AI674190, AK024003
      Consensus CDS
      CCDS40.1
      UniProtKB/Swiss-Prot
      A6NKZ6, Q5T089, Q8WW30, Q9H852
      Related
      ENSP00000367792.3, ENST00000378531.8
      Conserved Domains (2) summary
      COG4642
      Location:59 → 191
      COG4642; Uncharacterized conserved protein [Function unknown]
      pfam02493
      Location:39 → 61
      MORN; MORN repeat

    RNA

    1. NR_125361.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks multiple exons and contains two alternate 3' terminal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI188092, AK128431, AK299217, AL513477
      Related
      ENST00000449373.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      2321253..2391554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      1757185..1830823 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5T089.2 GenPept UniProtKB/Swiss-Prot:Q5T089

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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