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    B4GAT1 beta-1,4-glucuronyltransferase 1 [ Homo sapiens (human) ]

    Gene ID: 11041, updated on 17-Sep-2024

    Summary

    Official Symbol
    B4GAT1provided by HGNC
    Official Full Name
    beta-1,4-glucuronyltransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:15685
    See related
    Ensembl:ENSG00000174684 MIM:605517; AllianceGenome:HGNC:15685
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    iGAT; iGNT; B3GNT1; B3GNT6; B3GN-T1; MDDGA13; BETA3GNTI
    Summary
    This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It is essential for the synthesis of poly-N-acetyllactosamine, a determinant for the blood group i antigen. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in brain (RPKM 72.1), adrenal (RPKM 23.3) and 22 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See B4GAT1 in Genome Data Viewer
    Location:
    11q13.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (66345374..66347629, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (66339037..66341292, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66112845..66115100, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Ras and Rab interactor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66104385-66105239 Neighboring gene BRMS1 transcriptional repressor and anoikis regulator Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:66112315-66112865 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3589 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66115760-66116260 Neighboring gene tRNA-Ser (anticodon GCT) 3-1 Neighboring gene B4GAT1 divergent transcript Neighboring gene solute carrier family 29 member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3590

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef The yeast two-hybrid screen identifies the HIV-1 Nef interacting human protein UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1) in cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in keratan sulfate biosynthetic process TAS
    Traceable Author Statement
    more info
     
    NOT involved_in poly-N-acetyllactosamine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein O-linked mannosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein O-linked mannosylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in Golgi membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 

    General protein information

    Preferred Names
    beta-1,4-glucuronyltransferase 1
    Names
    N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
    beta-1,3-N-acetylglucosaminyltransferase bGnT-6
    i-beta-1,3-N-acetylglucosaminyltransferase
    poly-N-acetyllactosamine extension enzyme
    NP_006867.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033202.1 RefSeqGene

      Range
      5062..7317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006876.3NP_006867.1  beta-1,4-glucuronyltransferase 1

      See identical proteins and their annotated locations for NP_006867.1

      Status: REVIEWED

      Source sequence(s)
      AF029893, DA169103
      Consensus CDS
      CCDS8136.1
      UniProtKB/Swiss-Prot
      O43505, Q4TTN0
      UniProtKB/TrEMBL
      B3KQQ7
      Related
      ENSP00000309096.4, ENST00000311181.5
      Conserved Domains (1) summary
      pfam13896
      Location:94408
      Glyco_transf_49; Glycosyl-transferase for dystroglycan

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      66345374..66347629 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      66339037..66341292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)