PDE4D phosphodiesterase 4D [Homo sapiens (human)] - Gene

Summary

Official Symbol: PDE4Dprovided by HGNC
Official Full Name: phosphodiesterase 4Dprovided by HGNC
Primary source: HGNC:HGNC:8783
See related: Ensembl:ENSG00000113448 MIM:600129; AllianceGenome:HGNC:8783
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DPDE3; PDE43; STRK1; ACRDYS2; HSPDE4D; PDE4DN2
Summary: This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
Expression: Broad expression in bone marrow (RPKM 7.8), lung (RPKM 3.1) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q11.2-q12.1

Exon count:: 42

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (58969038..60522128, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (59787596..61345916, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (58264865..59792113, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GNAS mutation inhibits growth and induces phosphodiesterase 4D expression in colorectal cancer cell lines.
Title: GNAS mutation inhibits growth and induces phosphodiesterase 4D expression in colorectal cancer cell lines.
Association of the PDE4D gene variant with selected markers in individuals with ischaemic heart disease: a pilot study.
Title: Association of the PDE4D gene variant with selected markers in individuals with ischaemic heart disease: a pilot study.
PDE4D single nucleotide polymorphism rs918592 is associated with ischemic Stroke risk in Chinese populations: a meta-analysis.
Title: PDE4D single nucleotide polymorphism rs918592 is associated with ischemic Stroke risk in Chinese populations: a meta-analysis.
Phosphodiesterase 4 D (PDE4D) gene polymorphisms and risk of ischemic stroke: A systematic review and meta-analysis.
Title: Phosphodiesterase 4 D (PDE4D) gene polymorphisms and risk of ischemic stroke: A systematic review and meta-analysis.
[Research progress on genetic variants of PDE4D and susceptibility to stroke in Chinese population].
Title: [Research progress on genetic variants of PDE4D and susceptibility to stroke in Chinese population].
PDE4D gene variants and haplotypes are associated with asthma and atopy in Brazilian children.
Title: PDE4D gene variants and haplotypes are associated with asthma and atopy in Brazilian children.
Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth.
Title: Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth.
Phosphodiesterase 4D contributes to angiotensin II-induced abdominal aortic aneurysm through smooth muscle cell apoptosis.
Title: Phosphodiesterase 4D contributes to angiotensin II-induced abdominal aortic aneurysm through smooth muscle cell apoptosis.
Association of plaque enhancement on vessel wall MRI and the phosphodiesterase 4D variant with stroke recurrence in patients with symptomatic intracranial atherosclerosis.
Title: Association of plaque enhancement on vessel wall MRI and the phosphodiesterase 4D variant with stroke recurrence in patients with symptomatic intracranial atherosclerosis.
The relationship between phosphodiesterase 4D gene polymorphism and coronary heart disease.
Title: The relationship between phosphodiesterase 4D gene polymorphism and coronary heart disease.

Submit: New GeneRIF Correction See all GeneRIFs (154)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Acrodysostosis 2 with or without hormone resistance MedGen: C3553250 OMIM: 614613 GeneReviews: Not available	Compare labs

Copy number response

Description
Copy number response Haploinsufficency No evidence available (Last evaluated 2018-02-02) ClinGen Genome Curation Page Triplosensitivity No evidence available (Last evaluated 2018-02-02) ClinGen Genome Curation Page

EBI GWAS Catalog

Description
A whole genome association study of neuroticism using DNA pooling. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association of sleep and circadian phenotypes. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment. EBI GWAS Catalog EBI GWAS CatalogPubMed
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Cyclic AMP phosphodiesterase inhibitors AV411 and AV1013 inhibit HIV-1 replication and block HIV-1 Tat-induced neurotoxicity in human microglia, suggesting that cyclic AMP phosphodiesterase is involved in the Tat-mediated neurotoxicity	PubMed
	tat	HIV-1 Tat decreases the intracellular levels of cAMP and CREB ser-133 phosphorylation through a signal transduction pathway involving sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-16394 (e-PCR)
- UniSTS:34817

WI-16881 (e-PCR)
- UniSTS:15887

RH102705 (e-PCR)
- UniSTS:97039

L28295 (e-PCR)
- UniSTS:15121

SHGC-12987 (e-PCR)
- UniSTS:11284

RH122905 (e-PCR)
- UniSTS:135202

G16934 (e-PCR)
- UniSTS:16932

D5S2201E (e-PCR)
- UniSTS:154407

RH65738 (e-PCR)
- UniSTS:1323

D5S2091 (e-PCR), detects polymorphism
- UniSTS:48173

RH69750 (e-PCR)
- UniSTS:68911

SHGC-104922 (e-PCR)
- UniSTS:169017

D5S524 (e-PCR)
- UniSTS:148284

G09934 (e-PCR)
- UniSTS:30270

PDE4D_4140 (e-PCR)
- UniSTS:462916

D4S393 (e-PCR), detects polymorphism
- UniSTS:77125

SHGC-105334 (e-PCR)
- UniSTS:169285

L31464 (e-PCR)
- UniSTS:14161

D5S398 (e-PCR), detects polymorphism
- UniSTS:58964

RH78454 (e-PCR)
- UniSTS:67926

D5S2376 (e-PCR)
- UniSTS:74839

RH122295 (e-PCR)
- UniSTS:137822

RH17464 (e-PCR)
- UniSTS:50014

BB520687 (e-PCR)
- UniSTS:208991

D5S1371 (e-PCR)
- UniSTS:149089

RH48896 (e-PCR)
- UniSTS:51811

SHGC-146424 (e-PCR)
- UniSTS:175207

SHGC-142295 (e-PCR)
- UniSTS:171370

L28370 (e-PCR)
- UniSTS:4459

RH36510 (e-PCR)
- UniSTS:81007

SHGC-14303 (e-PCR)
- UniSTS:5246

RH36173 (e-PCR)
- UniSTS:42127

STS-N30417 (e-PCR)
- UniSTS:47247

SHGC-79022 (e-PCR)
- UniSTS:184221

D5S1474 (e-PCR), detects polymorphism
- UniSTS:10654

SHGC-82787 (e-PCR)
- UniSTS:100769

D5S2080 (e-PCR), detects polymorphism
- UniSTS:47267

D5S431 (e-PCR), detects polymorphism
- UniSTS:52389

SHGC-79957 (e-PCR)
- UniSTS:184234

SHGC-141822 (e-PCR)
- UniSTS:173998

NoName (e-PCR)
- UniSTS:50606

D5S612 (e-PCR)
- UniSTS:29620

RH122480 (e-PCR)
- UniSTS:135353

RH103654 (e-PCR)
- UniSTS:97979

D7S1938 (e-PCR)
- UniSTS:36028

L28399 (e-PCR)
- UniSTS:45245

PDE4D (e-PCR)
- UniSTS:505795

D5S2500 (e-PCR), detects polymorphism
- UniSTS:76230

D5S2071 (e-PCR)
- UniSTS:68554

SHGC-142883 (e-PCR)
- UniSTS:171722

D5S1765 (e-PCR)
- UniSTS:81123

L28248 (e-PCR)
- UniSTS:4339

SHGC-142103 (e-PCR)
- UniSTS:171253

RH120042 (e-PCR)
- UniSTS:133366

D5S468 (e-PCR), detects polymorphism
- UniSTS:2041

SHGC-79827 (e-PCR)
- UniSTS:101114

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-AMP phosphodiesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3',5'-cyclic-AMP phosphodiesterase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables 3',5'-cyclic-AMP phosphodiesterase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 3',5'-cyclic-AMP phosphodiesterase activity	TAS Traceable Author Statement more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	NAS Non-traceable Author Statement more info	PubMed
enables ATPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables beta-2 adrenergic receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables cAMP binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel regulator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables enzyme binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables heterocyclic compound binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adrenergic receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cAMP catabolic process	IEA Inferred from Electronic Annotation more info
involved_in cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to cAMP	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to epinephrine stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of endothelial barrier	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of heart contraction	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of peptidyl-serine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of relaxation of cardiac muscle	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of heart rate	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-2 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-5 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cardiac muscle cell contraction	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of cell communication by electrical coupling involved in cardiac conduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of heart rate	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
part_of calcium channel complex	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
NOT located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
part_of voltage-gated calcium channel complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: 3',5'-cyclic-AMP phosphodiesterase 4D

Names: cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D6; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); testicular tissue protein Li 136

NP_001098101.1

EC 3.1.4.53

NP_001159371.1

EC 3.1.4.53

NP_001184147.1

EC 3.1.4.53

NP_001184148.1

EC 3.1.4.53

NP_001184149.1

EC 3.1.4.53

NP_001184150.1

EC 3.1.4.53

NP_001184151.1

EC 3.1.4.53

NP_001184152.1

EC 3.1.4.53

NP_001336170.1

EC 3.1.4.53

NP_001336171.1

EC 3.1.4.53

NP_001336172.1

EC 3.1.4.53

NP_001351528.1

EC 3.1.4.53

NP_001351529.1

EC 3.1.4.53

NP_001351530.1

EC 3.1.4.53

NP_001351531.1

EC 3.1.4.53

NP_001351532.1

EC 3.1.4.53

NP_001351533.1

EC 3.1.4.53

NP_006194.2

EC 3.1.4.53

XP_011541771.1

EC 3.1.4.53

XP_011541775.1

EC 3.1.4.53

XP_016865055.1

EC 3.1.4.53

XP_016865056.1

EC 3.1.4.53

XP_024301878.1

EC 3.1.4.53

XP_024301880.1

EC 3.1.4.53

XP_047273249.1

EC 3.1.4.53

XP_047273250.1

EC 3.1.4.53

XP_047273251.1

EC 3.1.4.53

XP_047273252.1

EC 3.1.4.53

XP_047273253.1

EC 3.1.4.53

XP_047273254.1

EC 3.1.4.53

XP_047273255.1

EC 3.1.4.53

XP_047273256.1

EC 3.1.4.53

XP_047273257.1

EC 3.1.4.53

XP_054208753.1

EC 3.1.4.53

XP_054208754.1

EC 3.1.4.53

XP_054208755.1

EC 3.1.4.53

XP_054208756.1

EC 3.1.4.53

XP_054208757.1

EC 3.1.4.53

XP_054208758.1

EC 3.1.4.53

XP_054208759.1

EC 3.1.4.53

XP_054208760.1

EC 3.1.4.53

XP_054208761.1

EC 3.1.4.53

XP_054208762.1

EC 3.1.4.53

XP_054208763.1

EC 3.1.4.53

XP_054208764.1

EC 3.1.4.53

XP_054208765.1

EC 3.1.4.53

XP_054208766.1

EC 3.1.4.53

XP_054208767.1

EC 3.1.4.53

XP_054208768.1

EC 3.1.4.53

XP_054208769.1

EC 3.1.4.53

XP_054208770.1

EC 3.1.4.53

XP_054208771.1

EC 3.1.4.53

XP_054208772.1

EC 3.1.4.53

XP_054208773.1

EC 3.1.4.53

XP_054208774.1

EC 3.1.4.53

XP_054208775.1

EC 3.1.4.53

XP_054208776.1

EC 3.1.4.53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_027957.2 RefSeqGene

Range

635604..1560292

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001104631.2 → NP_001098101.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D4

See identical proteins and their annotated locations for NP_001098101.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (PDE4D4, also known as isoform 1).

Source sequence(s)

AC027322, AC092343, BF197530, L20969

Consensus CDS

CCDS47213.1

UniProtKB/Swiss-Prot

O43433, Q08499, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q96HL4, Q9HCX7

UniProtKB/TrEMBL

A0A140VJR0

Related

ENSP00000345502.6, ENST00000340635.11

Conserved Domains (1) summary

pfam00233
Location:461 → 702

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001165899.2 → NP_001159371.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D7

See identical proteins and their annotated locations for NP_001159371.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D7 (also known as isoform 3) has a shorter and distinct N-terminus, compared to isoform PDE4D4. Variants 3 and 13 both encode the same isoform (PDE4D7).

Source sequence(s)

AC092343, AY245866, BI492585, DB230503

Consensus CDS

CCDS54859.1

UniProtKB/Swiss-Prot

Q08499

Related

ENSP00000423094.2, ENST00000502484.6

Conserved Domains (2) summary

pfam00233
Location:400 → 641

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam18100
Location:162 → 278

PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
NM_001197218.2 → NP_001184147.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D5

See identical proteins and their annotated locations for NP_001184147.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D5 (also known as isoform 4) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.

Source sequence(s)

AC027322, AC092343, AF012073, BF197530

Consensus CDS

CCDS56373.1

UniProtKB/Swiss-Prot

Q08499

Related

ENSP00000424852.1, ENST00000507116.6

Conserved Domains (2) summary

pfam00233
Location:397 → 638

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam18100
Location:159 → 275

PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
NM_001197219.2 → NP_001184148.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D8

See identical proteins and their annotated locations for NP_001184148.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D8 (also known as isoform 5) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.

Source sequence(s)

AC008791, AC092343, AF012073, AF536977, BF197530

Consensus CDS

CCDS56372.1

UniProtKB/Swiss-Prot

Q08499

Related

ENSP00000384806.2, ENST00000405755.6

Conserved Domains (1) summary

pfam00233
Location:339 → 576

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001197220.2 → NP_001184149.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D9

See identical proteins and their annotated locations for NP_001184149.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D9 (also known as isoform 6) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.

Source sequence(s)

AC092343, AF012073, AY245867, BF197530

Consensus CDS

CCDS56371.1

UniProtKB/Swiss-Prot

Q08499

Related

ENSP00000425605.1, ENST00000503258.5

Conserved Domains (2) summary

pfam00233
Location:331 → 572

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam18100
Location:93 → 209

PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
NM_001197221.2 → NP_001184150.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D2

See identical proteins and their annotated locations for NP_001184150.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D2 (also known as isoform 7) is shorter at the N-terminus, compared to isoform PDE4D4. Variants 7 and 17 both encode the same isoform (PDE4D2).

Source sequence(s)

AC092343, AF012074, BF197530

Consensus CDS

CCDS56370.1

UniProtKB/TrEMBL

D6RHE0

Related

ENSP00000351800.6, ENST00000358923.10

Conserved Domains (2) summary

pfam00233
Location:159 → 400

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam18100
Location:1 → 37

PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
NM_001197222.2 → NP_001184151.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D1

See identical proteins and their annotated locations for NP_001184151.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D1 (also known as isoform 8) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.

Source sequence(s)

AC092343, AF012074, BF197530, U50157

UniProtKB/Swiss-Prot

Q08499

Conserved Domains (1) summary

pfam00233
Location:237 → 478

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001197223.2 → NP_001184152.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D6

See identical proteins and their annotated locations for NP_001184152.1

Status: REVIEWED

Description

Transcript Variant: This variant (9) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D6 (also known as isoform 9) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.

Source sequence(s)

AC092343, AF536975, BC036319, BF197530

Consensus CDS

CCDS56369.1

UniProtKB/TrEMBL

D6RHE0

Related

ENSP00000321739.8, ENST00000317118.12

Conserved Domains (2) summary

pfam00233
Location:170 → 411

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam18100
Location:16 → 48

PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
NM_001349241.2 → NP_001336170.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform 10

Status: REVIEWED

Description

Transcript Variant: This variant (10) differs in the 5' UTR and coding region, compared to variant 1. Isoform 10 is shorter and has a distinct N-terminus, compared to isoform PDE4D4.

Source sequence(s)

AC091955, AC092343, AY245866, BI492585, DB230503

Conserved Domains (2) summary

pfam00233
Location:390 → 631

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam18100
Location:152 → 268

PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
NM_001349242.2 → NP_001336171.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform 11

Status: REVIEWED

Description

Transcript Variant: This variant (11) differs in the 5' UTR and coding region, compared to variant 1. Isoform 11 is shorter and has a distinct N-terminus, compared to isoform PDE4D4.

Source sequence(s)

AC008791, AC092343, AC117527, BF197530, L20970, U50159

Consensus CDS

CCDS87297.1

UniProtKB/TrEMBL

A0A1B0GW84

Related

ENSP00000490821.1, ENST00000636120.1

Conserved Domains (2) summary

pfam00233
Location:351 → 592

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam18100
Location:113 → 229

PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
NM_001349243.2 → NP_001336172.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform 12

Status: REVIEWED

Description

Transcript Variant: This variant (12) differs in the 5' UTR and coding region, compared to variant 1. Isoform 12 is shorter and has a distinct N-terminus, compared to isoform PDE4D4. Variants 12 and 18 both encode the same isoform (12).

Source sequence(s)

AC091955, AC092343, AY245866, BI492585, DB230503

Conserved Domains (2) summary

pfam00233
Location:205 → 446

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam18100
Location:1 → 83

PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
NM_001364599.1 → NP_001351528.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D7

Status: REVIEWED

Description

Transcript Variant: This variant (13), as well as variant 3, encodes isoform PDE4D7.

Source sequence(s)

AC008818, AC008829, AC008934, AC091955, AC092343

Consensus CDS

CCDS54859.1

Conserved Domains (2) summary

pfam00233
Location:400 → 641

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam18100
Location:162 → 278

PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
NM_001364600.2 → NP_001351529.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform 14

Status: REVIEWED

Source sequence(s)

AC008829, AC008934, AC091955, AC109486
NM_001364601.1 → NP_001351530.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform 15

Status: REVIEWED

Source sequence(s)

AC008829, AC027322
NM_001364602.2 → NP_001351531.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform 16

Status: REVIEWED

Source sequence(s)

AC008829, AC027322, BC008390

Consensus CDS

CCDS93714.1

Related

ENSP00000425917.1, ENST00000502575.1

Conserved Domains (1) summary

pfam18100
Location:159 → 204

PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
NM_001364603.1 → NP_001351532.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D2

Status: REVIEWED

Description

Transcript Variant: This variant (17), as well as variant 7, encodes isoform PDE4D2.

Source sequence(s)

AC027322, AC092343, AJ250854

Consensus CDS

CCDS56370.1

UniProtKB/TrEMBL

D6RHE0

Conserved Domains (2) summary

pfam00233
Location:159 → 400

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam18100
Location:1 → 37

PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
NM_001364604.1 → NP_001351533.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform 12

Status: REVIEWED

Description

Transcript Variant: This variant (18), as well as variant 12, encodes isoform 12.

Source sequence(s)

AC008829, AC092343, AC117527

Conserved Domains (2) summary

pfam00233
Location:205 → 446

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam18100
Location:1 → 83

PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
NM_006203.5 → NP_006194.2 3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D3

See identical proteins and their annotated locations for NP_006194.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D3 (also known as isoform 2) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.

Source sequence(s)

AC092343, AC117527, BF197530, L20970, U50159

Consensus CDS

CCDS54858.1

UniProtKB/Swiss-Prot

Q08499

Related

ENSP00000353152.5, ENST00000360047.9

Conserved Domains (2) summary

pfam00233
Location:325 → 566

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam18100
Location:87 → 203

PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

58969038..60522128 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024446112.2 → XP_024301880.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

Conserved Domains (2) summary

pfam00233
Location:400 → 641

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam18100
Location:162 → 278

PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
XM_024446110.2 → XP_024301878.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

Conserved Domains (1) summary

pfam00233
Location:449 → 686

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
XM_047417295.1 → XP_047273251.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X4
XM_017009566.1 → XP_016865055.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

UniProtKB/Swiss-Prot

Q08499

Conserved Domains (2) summary

pfam00233
Location:400 → 641

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam18100
Location:162 → 278

PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
XM_047417294.1 → XP_047273250.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X2
XM_011543473.2 → XP_011541775.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

See identical proteins and their annotated locations for XP_011541775.1

UniProtKB/Swiss-Prot

Q08499

Conserved Domains (2) summary

pfam00233
Location:400 → 641

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam18100
Location:162 → 278

PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
XM_047417293.1 → XP_047273249.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X2
XM_011543469.2 → XP_011541771.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

See identical proteins and their annotated locations for XP_011541771.1

Conserved Domains (1) summary

pfam00233
Location:449 → 686

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
XM_017009567.1 → XP_016865056.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X3

Conserved Domains (2) summary

pfam00233
Location:395 → 636

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam18100
Location:157 → 273

PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
XM_047417297.1 → XP_047273253.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X6
XM_047417296.1 → XP_047273252.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X5
XM_047417298.1 → XP_047273254.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X7
XM_047417299.1 → XP_047273255.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X7
XM_047417301.1 → XP_047273257.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X9
XM_047417300.1 → XP_047273256.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X8

Alternate T2T-CHM13v2.0

Genomic

NC_060929.1 Alternate T2T-CHM13v2.0

Range

59787596..61345916 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054352788.1 → XP_054208763.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X2
XM_054352780.1 → XP_054208755.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X1
XM_054352789.1 → XP_054208764.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X2
XM_054352790.1 → XP_054208765.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X2
XM_054352793.1 → XP_054208768.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X2
XM_054352782.1 → XP_054208757.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X1
XM_054352781.1 → XP_054208756.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X1
XM_054352783.1 → XP_054208758.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X1
XM_054352785.1 → XP_054208760.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X2
XM_054352792.1 → XP_054208767.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X2
XM_054352795.1 → XP_054208770.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X4
XM_054352784.1 → XP_054208759.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X2
XM_054352778.1 → XP_054208753.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X1
XM_054352787.1 → XP_054208762.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X2
XM_054352791.1 → XP_054208766.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X2
XM_054352779.1 → XP_054208754.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X1
XM_054352786.1 → XP_054208761.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X2
XM_054352794.1 → XP_054208769.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X3
XM_054352799.1 → XP_054208774.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X6
XM_054352798.1 → XP_054208773.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X5
XM_054352797.1 → XP_054208772.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X5
XM_054352796.1 → XP_054208771.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X10
XM_054352800.1 → XP_054208775.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X7
XM_054352801.1 → XP_054208776.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X8