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    SLITRK2 SLIT and NTRK like family member 2 [ Homo sapiens (human) ]

    Gene ID: 84631, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SLITRK2provided by HGNC
    Official Full Name
    SLIT and NTRK like family member 2provided by HGNC
    Primary source
    HGNC:HGNC:13449
    See related
    Ensembl:ENSG00000185985 MIM:300561; AllianceGenome:HGNC:13449
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CXorf1; CXorf2; SLITL1; TMEM257; XLID111
    Summary
    This gene encodes an integral membrane protein that contains two N-terminal leucine-rich repeats domains and contains C-terminal regions similar to neurotrophin receptors. The encoded protein may play a role in modulating neurite activity. Alternatively spliced transcript variants encoding the same protein have been described.[provided by RefSeq, Feb 2010]
    Expression
    Biased expression in brain (RPKM 6.9), spleen (RPKM 1.8) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SLITRK2 in Genome Data Viewer
    Location:
    Xq27.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (145817829..145829856)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (144074860..144086894)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (144899347..144911374)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene TRMT1 pseudogene 1 Neighboring gene UFM1 pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:144884451-144885034 Neighboring gene uncharacterized LOC107985703 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:144939449-144940648 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:144947148-144947676 Neighboring gene microRNA 892c

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of CXorf1, a novel intronless gene in Xq27.3, expressed in human hippocampus. Redolfi E, et al. DNA Cell Biol, 1998 Dec. PMID 9881668
    2. SLITRK2 variants associated with neurodevelopmental disorders impair excitatory synaptic function and cognition in mice. El Chehadeh S, et al. Nat Commun, 2022 Jul 15. PMID 35840571, Free PMC Article
    3. Slitrk1 is localized to excitatory synapses and promotes their development. Beaubien F, et al. Sci Rep, 2016 Jun 7. PMID 27273464, Free PMC Article
    4. Genome-wide association study of bipolar disorder in European American and African American individuals. Smith EN, et al. Mol Psychiatry, 2009 Aug. PMID 19488044, Free PMC Article
    5. Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia. Piton A, et al. Mol Psychiatry, 2011 Aug. PMID 20479760, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia.
    2. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Genome-wide association study of bipolar disorder in European American and African American individuals.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Intellectual developmental disorder, X-linked 111
    MedGen: C5829568 OMIM: 301107 GeneReviews: Not available
    		not available

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of SLITRK2 (CXorf1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1854, MGC129912, MGC129913, MGC142160, MGC142164, DKFZp547F175, DKFZp451E1911

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of synapse assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of synapse assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of presynapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of presynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synapse organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic membrane adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic membrane adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    SLIT and NTRK-like protein 2
    Names
    slit and trk like gene 2
    slit-like 1
    transmembrane protein 257

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016477.3 RefSeqGene

      Range
      5002..17029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144003.3 → NP_001137475.1  SLIT and NTRK-like protein 2 precursor

      See identical proteins and their annotated locations for NP_001137475.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All 9 variants encode the same protein.
      Source sequence(s)
      AK289732, AL109653, BM669862, DA239165
      Consensus CDS
      CCDS14680.1
      UniProtKB/Swiss-Prot
      A8K117, Q2KHN3, Q5JXB1, Q8NBC7, Q96JH3, Q9H156
      UniProtKB/TrEMBL
      Q6AI13
      Conserved Domains (7) summary
      smart00082
      Location:529 → 579
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:82 → 217
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:496 → 509
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:67 → 87
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:423 → 466
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:399 → 459
      LRR_8; Leucine rich repeat
      cl15307
      Location:216 → 252
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    2. NM_001144004.3 → NP_001137476.1  SLIT and NTRK-like protein 2 precursor

      See identical proteins and their annotated locations for NP_001137476.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All 9 variants encode the same protein.
      Source sequence(s)
      AK289732, AL109653, BM669862, DA239165, DA412276
      Consensus CDS
      CCDS14680.1
      UniProtKB/Swiss-Prot
      A8K117, Q2KHN3, Q5JXB1, Q8NBC7, Q96JH3, Q9H156
      UniProtKB/TrEMBL
      Q6AI13
      Conserved Domains (7) summary
      smart00082
      Location:529 → 579
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:82 → 217
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:496 → 509
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:67 → 87
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:423 → 466
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:399 → 459
      LRR_8; Leucine rich repeat
      cl15307
      Location:216 → 252
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    3. NM_001144005.3 → NP_001137477.1  SLIT and NTRK-like protein 2 precursor

      See identical proteins and their annotated locations for NP_001137477.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All 9 variants encode the same protein.
      Source sequence(s)
      AK289732, AL109653, BM669862, DA234617, DA239165
      Consensus CDS
      CCDS14680.1
      UniProtKB/Swiss-Prot
      A8K117, Q2KHN3, Q5JXB1, Q8NBC7, Q96JH3, Q9H156
      UniProtKB/TrEMBL
      Q6AI13
      Conserved Domains (7) summary
      smart00082
      Location:529 → 579
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:82 → 217
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:496 → 509
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:67 → 87
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:423 → 466
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:399 → 459
      LRR_8; Leucine rich repeat
      cl15307
      Location:216 → 252
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    4. NM_001144006.2 → NP_001137478.1  SLIT and NTRK-like protein 2 precursor

      See identical proteins and their annotated locations for NP_001137478.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All 9 variants encode the same protein.
      Source sequence(s)
      AK096278, AK289732, AL109653, BC113011, BM669862
      Consensus CDS
      CCDS14680.1
      UniProtKB/Swiss-Prot
      A8K117, Q2KHN3, Q5JXB1, Q8NBC7, Q96JH3, Q9H156
      UniProtKB/TrEMBL
      Q6AI13
      Conserved Domains (7) summary
      smart00082
      Location:529 → 579
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:82 → 217
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:496 → 509
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:67 → 87
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:423 → 466
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:399 → 459
      LRR_8; Leucine rich repeat
      cl15307
      Location:216 → 252
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    5. NM_001144008.2 → NP_001137480.1  SLIT and NTRK-like protein 2 precursor

      See identical proteins and their annotated locations for NP_001137480.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. All 9 variants encode the same protein.
      Source sequence(s)
      AK096278, AK289732, AL109653, BM669862, DA184412
      Consensus CDS
      CCDS14680.1
      UniProtKB/Swiss-Prot
      A8K117, Q2KHN3, Q5JXB1, Q8NBC7, Q96JH3, Q9H156
      UniProtKB/TrEMBL
      Q6AI13
      Conserved Domains (7) summary
      smart00082
      Location:529 → 579
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:82 → 217
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:496 → 509
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:67 → 87
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:423 → 466
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:399 → 459
      LRR_8; Leucine rich repeat
      cl15307
      Location:216 → 252
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    6. NM_001144009.2 → NP_001137481.1  SLIT and NTRK-like protein 2 precursor

      See identical proteins and their annotated locations for NP_001137481.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. All 9 variants encode the same protein.
      Source sequence(s)
      AK096278, AK289732, AL109653, BM669862, DA496247
      Consensus CDS
      CCDS14680.1
      UniProtKB/Swiss-Prot
      A8K117, Q2KHN3, Q5JXB1, Q8NBC7, Q96JH3, Q9H156
      UniProtKB/TrEMBL
      Q6AI13
      Conserved Domains (7) summary
      smart00082
      Location:529 → 579
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:82 → 217
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:496 → 509
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:67 → 87
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:423 → 466
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:399 → 459
      LRR_8; Leucine rich repeat
      cl15307
      Location:216 → 252
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    7. NM_001144010.2 → NP_001137482.1  SLIT and NTRK-like protein 2 precursor

      See identical proteins and their annotated locations for NP_001137482.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. All 9 variants encode the same protein.
      Source sequence(s)
      AK096278, AK289732, AL109653, BM669862, DA332123
      Consensus CDS
      CCDS14680.1
      UniProtKB/Swiss-Prot
      A8K117, Q2KHN3, Q5JXB1, Q8NBC7, Q96JH3, Q9H156
      UniProtKB/TrEMBL
      Q6AI13
      Conserved Domains (7) summary
      smart00082
      Location:529 → 579
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:82 → 217
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:496 → 509
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:67 → 87
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:423 → 466
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:399 → 459
      LRR_8; Leucine rich repeat
      cl15307
      Location:216 → 252
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    8. NM_032539.5 → NP_115928.1  SLIT and NTRK-like protein 2 precursor

      See identical proteins and their annotated locations for NP_115928.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All 9 variants encode the same protein.
      Source sequence(s)
      AK096278, AK289732, AL109653, BM669862, DA239165
      Consensus CDS
      CCDS14680.1
      UniProtKB/Swiss-Prot
      A8K117, Q2KHN3, Q5JXB1, Q8NBC7, Q96JH3, Q9H156
      UniProtKB/TrEMBL
      Q6AI13
      Related
      ENSP00000334374.5, ENST00000335565.6
      Conserved Domains (7) summary
      smart00082
      Location:529 → 579
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:82 → 217
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:496 → 509
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:67 → 87
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:423 → 466
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:399 → 459
      LRR_8; Leucine rich repeat
      cl15307
      Location:216 → 252
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      145817829..145829856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005262343.4 → XP_005262400.1  SLIT and NTRK-like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005262400.1

      UniProtKB/Swiss-Prot
      A8K117, Q2KHN3, Q5JXB1, Q8NBC7, Q96JH3, Q9H156
      UniProtKB/TrEMBL
      Q6AI13
      Conserved Domains (7) summary
      smart00082
      Location:529 → 579
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:82 → 217
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:496 → 509
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:67 → 87
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:423 → 466
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:399 → 459
      LRR_8; Leucine rich repeat
      cl15307
      Location:216 → 252
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    2. XM_005262342.4 → XP_005262399.1  SLIT and NTRK-like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005262399.1

      UniProtKB/Swiss-Prot
      A8K117, Q2KHN3, Q5JXB1, Q8NBC7, Q96JH3, Q9H156
      UniProtKB/TrEMBL
      Q6AI13
      Conserved Domains (7) summary
      smart00082
      Location:529 → 579
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:82 → 217
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:496 → 509
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:67 → 87
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:423 → 466
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:399 → 459
      LRR_8; Leucine rich repeat
      cl15307
      Location:216 → 252
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    3. XM_005262345.4 → XP_005262402.1  SLIT and NTRK-like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005262402.1

      UniProtKB/Swiss-Prot
      A8K117, Q2KHN3, Q5JXB1, Q8NBC7, Q96JH3, Q9H156
      UniProtKB/TrEMBL
      Q6AI13
      Conserved Domains (7) summary
      smart00082
      Location:529 → 579
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:82 → 217
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:496 → 509
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:67 → 87
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:423 → 466
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:399 → 459
      LRR_8; Leucine rich repeat
      cl15307
      Location:216 → 252
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    4. XM_047442577.1 → XP_047298533.1  SLIT and NTRK-like protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K117, Q2KHN3, Q5JXB1, Q8NBC7, Q96JH3, Q9H156
      Related
      ENSP00000359521.1, ENST00000370490.1

    5. XM_005262344.4 → XP_005262401.1  SLIT and NTRK-like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005262401.1

      UniProtKB/Swiss-Prot
      A8K117, Q2KHN3, Q5JXB1, Q8NBC7, Q96JH3, Q9H156
      UniProtKB/TrEMBL
      Q6AI13
      Conserved Domains (7) summary
      smart00082
      Location:529 → 579
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:82 → 217
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:496 → 509
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:67 → 87
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:423 → 466
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:399 → 459
      LRR_8; Leucine rich repeat
      cl15307
      Location:216 → 252
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    6. XM_047442578.1 → XP_047298534.1  SLIT and NTRK-like protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K117, Q2KHN3, Q5JXB1, Q8NBC7, Q96JH3, Q9H156

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      144074860..144086894
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327986.1 → XP_054183961.1  SLIT and NTRK-like protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K117, Q2KHN3, Q5JXB1, Q8NBC7, Q96JH3, Q9H156

    2. XM_054327985.1 → XP_054183960.1  SLIT and NTRK-like protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K117, Q2KHN3, Q5JXB1, Q8NBC7, Q96JH3, Q9H156

    3. XM_054327990.1 → XP_054183965.1  SLIT and NTRK-like protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K117, Q2KHN3, Q5JXB1, Q8NBC7, Q96JH3, Q9H156

    4. XM_054327987.1 → XP_054183962.1  SLIT and NTRK-like protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K117, Q2KHN3, Q5JXB1, Q8NBC7, Q96JH3, Q9H156

    5. XM_054327988.1 → XP_054183963.1  SLIT and NTRK-like protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K117, Q2KHN3, Q5JXB1, Q8NBC7, Q96JH3, Q9H156

    6. XM_054327989.1 → XP_054183964.1  SLIT and NTRK-like protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K117, Q2KHN3, Q5JXB1, Q8NBC7, Q96JH3, Q9H156

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001144007.1: Suppressed sequence

      Description
      NM_001144007.1: This RefSeq was permanently suppressed because it appears to be partial and is redundant to another public RefSeq.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H156.1 GenPept UniProtKB/Swiss-Prot:Q9H156

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