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    Plagl1 pleiomorphic adenoma gene-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 22634, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Plagl1provided by MGI
    Official Full Name
    pleiomorphic adenoma gene-like 1provided by MGI
    Primary source
    MGI:MGI:1100874
    See related
    Ensembl:ENSMUSG00000019817 AllianceGenome:MGI:1100874
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lot1; Zac1; 2610311E24Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within regulation of gene expression and skeletal muscle cell differentiation. Predicted to be located in Golgi apparatus and nuclear body. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; heart; and sensory organ. Orthologous to human PLAGL1 (PLAG1 like zinc finger 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 270.7), CNS E11.5 (RPKM 64.6) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plagl1 in Genome Data Viewer
    Location:
    10 A2; 10 4.72 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (12966576..13007438)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (13090832..13131694)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5119 Neighboring gene STARR-seq mESC enhancer starr_25807 Neighboring gene splicing factor 3b, subunit 5 Neighboring gene predicted gene, 40602 Neighboring gene STARR-seq mESC enhancer starr_25810 Neighboring gene hydatidiform mole associated and imprinted transcript Neighboring gene zinc finger, C2HC-type containing 1B Neighboring gene STARR-seq mESC enhancer starr_25812 Neighboring gene LTV1 ribosome biogenesis factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PLAGL1 overexpression induces cytoplasmic DNA accumulation that triggers cGAS/STING activation. Li C, et al. J Cell Mol Med, 2024 Oct. PMID 39365284, Free PMC Article
    2. Overexpression of ZAC impairs glucose-stimulated insulin translation and secretion in clonal pancreatic beta-cells. Du X, et al. Diabetes Metab Res Rev, 2012 Nov. PMID 22865650, Free PMC Article
    3. Zac1 promotes a Müller glial cell fate and interferes with retinal ganglion cell differentiation in Xenopus retina. Ma L, et al. Dev Dyn, 2007 Jan. PMID 17072860
    4. Down-regulation of the transcription factor ZAC1 upon pre- and postconditioning protects against I/R injury in the mouse myocardium. Vincent A, et al. Cardiovasc Res, 2012 May 1. PMID 22106414
    5. Zac1 is expressed in progenitor/stem cells of the neuroectoderm and mesoderm during embryogenesis: differential phenotype of the Zac1-expressing cells during development. Valente T, et al. Dev Dyn, 2005 Jun. PMID 15844099

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PLAGL1 overexpression induces cytoplasmic DNA accumulation that triggers cGAS/STING activation.
      Title: PLAGL1 overexpression induces cytoplasmic DNA accumulation that triggers cGAS/STING activation.
    2. Polycomb protein RYBP activates transcription factor Plagl1 during in vitro cardiac differentiation of mouse embryonic stem cells.
      Title: Polycomb protein RYBP activates transcription factor Plagl1 during in vitro cardiac differentiation of mouse embryonic stem cells.
    3. The imprinted gene Zac1 regulates steatosis in developmental cadmium-induced nonalcoholic fatty liver disease.
      Title: The imprinted gene Zac1 regulates steatosis in developmental cadmium-induced nonalcoholic fatty liver disease.
    4. Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to maternal metabolic syndrome.
      Title: Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to maternal metabolic syndrome.
    5. Transcription Factor PLAGL1 Is Associated with Angiogenic Gene Expression in the Placenta.
      Title: Transcription Factor PLAGL1 Is Associated with Angiogenic Gene Expression in the Placenta.
    6. PLAGL1 may regulate hypothalamic hypocretin transcription.
      Title: Involvement of PLAGL1/ZAC1 in hypocretin/orexin transcription.
    7. Zac1/GPR39 system promotes the formation of type II muscle fibers by phosphorylation of CaMK-II. Cells lacking Zac1/GPR39 system tend to remain stemness and form type I muscle fibers after induced differentiation.
      Title: Zac1/GPR39 phosphorylating CaMK-II contributes to the distinct roles of Pax3 and Pax7 in myogenic progression.
    8. Plagl1 is a transcription factor that coordinated the regulation of a subset of imprinted gene network genes and controlled extracellular matrix composition.
      Title: Identification of Plagl1/Zac1 binding sites and target genes establishes its role in the regulation of extracellular matrix genes and the imprinted gene network.
    9. expression levels of Zac1 need to be kept under strict control to avoid premature cell cycle exit, disrupted neurogenesis and aberrant expression of non-neuronal genes including pluripotency associated factors.
      Title: Elevated levels of ZAC1 disrupt neurogenesis and promote rapid in vivo reprogramming.
    10. Transcription factor MEF2 and Zac1 mediate MIF-induced GLUT4 expression through CD74-dependent AMPK activation in cardiomyocytes
      Title: Macrophage migration inhibitory factor promotes expression of GLUT4 glucose transporter through MEF2 and Zac1 in cardiomyocytes.
    Submit: New GeneRIF Correction See all GeneRIFs (30)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within skeletal muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein PLAGL1
    Names
    zinc finger protein regulator of apoptosis and cell cycle arrest

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364643.1 → NP_001351572.1  zinc finger protein PLAGL1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AK142052, AK142210, BC065150
      Consensus CDS
      CCDS87960.1
      UniProtKB/TrEMBL
      Q3UQW2
      Related
      ENSMUSP00000112889.2, ENSMUST00000121325.8
      Conserved Domains (3) summary
      COG5189
      Location:29 → 109
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:6 → 26
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:49 → 73
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001364644.1 → NP_001351573.1  zinc finger protein PLAGL1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AK142052, AK142210, BC065150
      Consensus CDS
      CCDS87960.1
      UniProtKB/TrEMBL
      Q3UQW2
      Related
      ENSMUSP00000113710.2, ENSMUST00000121766.8
      Conserved Domains (3) summary
      COG5189
      Location:29 → 109
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:6 → 26
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:49 → 73
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001364645.1 → NP_001351574.1  zinc finger protein PLAGL1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL691505, AL713985
      Consensus CDS
      CCDS87960.1
      UniProtKB/TrEMBL
      Q3UQW2
      Conserved Domains (3) summary
      COG5189
      Location:29 → 109
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:6 → 26
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:49 → 73
      zf-H2C2_2; Zinc-finger double domain

    4. NM_009538.3 → NP_033564.2  zinc finger protein PLAGL1 isoform a

      See identical proteins and their annotated locations for NP_033564.2

      Status: VALIDATED

      Source sequence(s)
      BC065150
      Consensus CDS
      CCDS48501.1
      UniProtKB/TrEMBL
      Q9JLQ4
      Related
      ENSMUSP00000112847.2, ENSMUST00000121646.8
      Conserved Domains (2) summary
      sd00017
      Location:6 → 26
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:49 → 73
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      12966576..13007438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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