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    Midn midnolin [ Mus musculus (house mouse) ]

    Gene ID: 59090, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Midnprovided by MGI
    Official Full Name
    midnolinprovided by MGI
    Primary source
    MGI:MGI:1890222
    See related
    Ensembl:ENSMUSG00000035621 AllianceGenome:MGI:1890222
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3000003C15Rik
    Summary
    This gene encodes a protein that contains an ubiquitin-like domain. This protein may be involved in the regulation of brain development as inferred by its high expression level in the embryonic midbrain. This protein has been found to negatively regulate glucokinase activity and insulin secretion in pancreatic beta cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 75.4), thymus adult (RPKM 75.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Midn in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79984106..79994202)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80146005..80158368)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27266 Neighboring gene serine/threonine kinase 11 Neighboring gene calcium channel, voltage-dependent, beta subunit associated regulatory protein Neighboring gene STARR-positive B cell enhancer ABC_E11444 Neighboring gene STARR-positive B cell enhancer ABC_E1806 Neighboring gene ATP synthase F1 subunit delta Neighboring gene STARR-seq mESC enhancer starr_27268 Neighboring gene STARR-seq mESC enhancer starr_27269 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:79621397-79621506 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:79622453-79622640 Neighboring gene STARR-positive B cell enhancer ABC_E2949 Neighboring gene cold inducible RNA binding protein Neighboring gene STARR-positive B cell enhancer ABC_E576 Neighboring gene family with sequence similarity 174, member C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Heterozygous midnolin knockout attenuates severity of nonalcoholic fatty liver disease in mice fed a Western-style diet high in fat, cholesterol, and fructose. Kweon SM, et al. Am J Physiol Gastrointest Liver Physiol, 2023 Aug 1. PMID 37129245, Free PMC Article
    2. Novel nucleolar protein, midnolin, is expressed in the mesencephalon during mouse development. Tsukahara M, et al. Gene, 2000 Aug 22. PMID 10974535
    3. Viable mutations of mouse midnolin suppress B cell malignancies. Zhong X, et al. J Exp Med, 2024 Jun 3. PMID 38625151, Free PMC Article
    4. Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partner. Hofmeister-Brix A, et al. J Biol Chem, 2013 Dec 13. PMID 24187134, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Viable mutations of mouse midnolin suppress B cell malignancies.
      Title: Viable mutations of mouse midnolin suppress B cell malignancies.
    2. Heterozygous midnolin knockout attenuates severity of nonalcoholic fatty liver disease in mice fed a Western-style diet high in fat, cholesterol, and fructose.
      Title: Heterozygous midnolin knockout attenuates severity of nonalcoholic fatty liver disease in mice fed a Western-style diet high in fat, cholesterol, and fructose.
    3. midnolin plays a role in cellular signaling of adult tissues and regulates glucokinase enzyme activity in pancreatic beta cells
      Title: Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partner.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Transgenic (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of glucokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of glucokinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in proteasomal ubiquitin-independent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    midnolin
    Names
    midbrain nucleolar protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305798.1 → NP_001292727.1  midnolin isoform 2

      See identical proteins and their annotated locations for NP_001292727.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5, and 9 all encode the same isoform (2).
      Source sequence(s)
      AB036882, AI117487, AK164651
      UniProtKB/Swiss-Prot
      Q3TPJ7
      Conserved Domains (1) summary
      cd01804
      Location:32 → 101
      Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

    2. NM_001305799.2 → NP_001292728.1  midnolin isoform 3

      See identical proteins and their annotated locations for NP_001292728.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Variants 3 and 8 both encode the same isoform (3).
      Source sequence(s)
      AB036882, AC159999, AI117487, BM944891, BY168322
      UniProtKB/Swiss-Prot
      Q3TPJ7
      Conserved Domains (1) summary
      cd01804
      Location:32 → 101
      Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

    3. NM_001347117.1 → NP_001334046.1  midnolin isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1. Variants 4, 6, and 7 all encode the same isoform (4).
      Source sequence(s)
      AB036882, AI117487, AK164324, AK164651
      Consensus CDS
      CCDS83727.1
      UniProtKB/Swiss-Prot
      Q3TPJ7, Q3U3X5, Q9JJJ6
      Related
      ENSMUSP00000097091.4, ENSMUST00000099492.10
      Conserved Domains (1) summary
      cd01804
      Location:32 → 101
      Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

    4. NM_001388475.1 → NP_001375404.1  midnolin isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC159999
      Conserved Domains (1) summary
      cd01804
      Location:32 → 101
      Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

    5. NM_001388476.1 → NP_001375405.1  midnolin isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC159999
      UniProtKB/Swiss-Prot
      Q3TPJ7, Q3U3X5, Q9JJJ6
      Conserved Domains (1) summary
      cd01804
      Location:32 → 101
      Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

    6. NM_001388477.1 → NP_001375406.1  midnolin isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC159999
      UniProtKB/Swiss-Prot
      Q3TPJ7, Q3U3X5, Q9JJJ6
      Conserved Domains (1) summary
      cd01804
      Location:32 → 101
      Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

    7. NM_001388478.1 → NP_001375407.1  midnolin isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC159999
      Conserved Domains (1) summary
      cd01804
      Location:32 → 101
      Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

    8. NM_001429288.1 → NP_001416217.1  midnolin isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC159999

    9. NM_001429289.1 → NP_001416218.1  midnolin isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC159999

    10. NM_001429290.1 → NP_001416219.1  midnolin isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC159999

    11. NM_001429291.1 → NP_001416220.1  midnolin isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC159999

    12. NM_021565.2 → NP_067540.1  midnolin isoform 1

      See identical proteins and their annotated locations for NP_067540.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AB036882, AI117487, AK164324
      Consensus CDS
      CCDS24011.1
      UniProtKB/Swiss-Prot
      Q3TPJ7
      Related
      ENSMUSP00000046967.6, ENSMUST00000042057.12
      Conserved Domains (1) summary
      cd01804
      Location:32 → 101
      Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      79984106..79994202
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513913.4 → XP_006513976.1  midnolin isoform X1

      See identical proteins and their annotated locations for XP_006513976.1

      UniProtKB/Swiss-Prot
      Q3TPJ7
      Conserved Domains (1) summary
      cd01804
      Location:32 → 101
      Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

    2. XM_036155903.1 → XP_036011796.1  midnolin isoform X4

    3. XM_030245189.2 → XP_030101049.1  midnolin isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TPJ7.1 GenPept UniProtKB/Swiss-Prot:Q3TPJ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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