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    Bin2 bridging integrator 2 [ Mus musculus (house mouse) ]

    Gene ID: 668218, updated on 8-May-2024

    Summary

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    Official Symbol
    Bin2provided by MGI
    Official Full Name
    bridging integrator 2provided by MGI
    Primary source
    MGI:MGI:3611448
    See related
    Ensembl:ENSMUSG00000098112 AllianceGenome:MGI:3611448
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable phospholipid binding activity. Predicted to be involved in several processes, including phagocytosis, engulfment; plasma membrane tubulation; and podosome assembly. Predicted to be active in plasma membrane and podosome. Predicted to colocalize with phagocytic cup. Is expressed in liver and thymus primordium. Orthologous to human BIN2 (bridging integrator 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in spleen adult (RPKM 26.2), thymus adult (RPKM 18.8) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bin2 in Genome Data Viewer
    Location:
    15 F1; 15 56.37 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (100538963..100567384, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100641082..100669503, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene DAZ associated protein 2 Neighboring gene small cell adhesion glycoprotein Neighboring gene microRNA 6961 Neighboring gene STARR-positive B cell enhancer ABC_E311 Neighboring gene chymotrypsin-like elastase family, member 1 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 6 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 6, opposite strand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BIN2 orchestrates platelet calcium signaling in thrombosis and thrombo-inflammation. Volz J, et al. J Clin Invest, 2020 Nov 2. PMID 32750041, Free PMC Article
    2. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    3. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibiting bridge integrator 2 phosphorylation leads to improved oocyte quality, ovarian health and fertility in aging and after chemotherapy in mice.
      Title: Inhibiting bridge integrator 2 phosphorylation leads to improved oocyte quality, ovarian health and fertility in aging and after chemotherapy in mice.
    2. BIN2 orchestrates platelet calcium signaling in thrombosis and thrombo-inflammation.
      Title: BIN2 orchestrates platelet calcium signaling in thrombosis and thrombo-inflammation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phagocytosis, engulfment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in plasma membrane tubulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma membrane tubulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in podosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in podosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with phagocytic cup IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with phagocytic cup ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in podosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in podosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    bridging integrator 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270537.2 → NP_001257466.1  bridging integrator 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC123724
      Consensus CDS
      CCDS59622.1
      UniProtKB/TrEMBL
      S4R1B8, S4R270
      Related
      ENSMUSP00000138523.2, ENSMUST00000183211.8
      Conserved Domains (1) summary
      cl12013
      Location:30 → 240
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. NM_001368666.1 → NP_001355595.1  bridging integrator 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC123724
      UniProtKB/TrEMBL
      S4R1B8
      Related
      ENSMUSP00000159169.2, ENSMUST00000238935.2
      Conserved Domains (1) summary
      cl12013
      Location:30 → 240
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      100538963..100567384 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521281.2 → XP_006521344.1  bridging integrator 2 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3Z6Q9.1 GenPept UniProtKB/Swiss-Prot:D3Z6Q9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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