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    eef-1A.2 Elongation factor 1-alpha [ Caenorhabditis elegans ]

    Gene ID: 181044, updated on 2-Nov-2024

    Summary

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    Official Symbol
    eef-1A.2
    Official Full Name
    Elongation factor 1-alpha
    Primary source
    WormBase:WBGene00001169
    Locus tag
    CELE_R03G5.1
    See related
    AllianceGenome:WB:WBGene00001169
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and translation elongation factor activity. Predicted to be involved in translational elongation. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 38; developmental and epileptic encephalopathy 33; and ovarian cancer. Orthologous to human EEF1A1 (eukaryotic translation elongation factor 1 alpha 1); EEF1A1P5 (eukaryotic translation elongation factor 1 alpha 1 pseudogene 5); and EEF1A2 (eukaryotic translation elongation factor 1 alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See eef-1A.2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    3
    Sequence:
    Chromosome: X; NC_003284.9 (7823654..7825769)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Dual specificity mitogen-activated protein kinase kinase sek-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Sulfatase N-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the biochemical activity and tumor-promoting role of the dual protein methyltransferase METL-13/METTL13 in Caenorhabditis elegans. Engelfriet ML, et al. PLoS One, 2023. PMID 37347777, Free PMC Article
    2. The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones. Truttmann MC, et al. PLoS Genet, 2016 May. PMID 27138431, Free PMC Article
    3. Autosomal genes of autosomal/X-linked duplicated gene pairs and germ-line proliferation in Caenorhabditis elegans. Maciejowski J, et al. Genetics, 2005 Apr. PMID 15687263, Free PMC Article
    4. Mass spectrometry-based shotgun proteomic analysis of C. elegans protein complexes. Fonslow BR, et al. WormBook, 2014 Jun 24. PMID 24967700, Free PMC Article
    5. An analysis of the Caenorhabditis elegans lipid raft proteome using geLC-MS/MS. Rao W, et al. J Proteomics, 2011 Feb 1. PMID 21070894

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Elongation factor 1-alpha
    NP_509323.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      7823654..7825769
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076922.5 → NP_509323.1  Elongation factor 1-alpha [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509323.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P53013
      Conserved Domains (4) summary
      PTZ00141
      Location:1 → 461
      PTZ00141; elongation factor 1- alpha; Provisional
      cd01883
      Location:9 → 239
      EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
      cd03693
      Location:242 → 332
      EF1_alpha_II; Domain II of elongation factor 1-alpha
      cd03705
      Location:335 → 438
      EF1_alpha_III; Domain III of Elongation Factor 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53013.1

    Gene LinkOut

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