Esx1 extraembryonic, spermatogenesis, homeobox 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Esx1provided by MGI
Official Full Name: extraembryonic, spermatogenesis, homeobox 1provided by MGI
Primary source: MGI:MGI:1096388
See related: Ensembl:ENSMUSG00000023443 AllianceGenome:MGI:1096388
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Spx1
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within labyrinthine layer blood vessel development; labyrinthine layer morphogenesis; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; hindlimb phalanx; and viscerocranium. Orthologous to human ESX1 (ESX homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward placenta adult (RPKM 11.8) See more
Orthologs: human all
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Genomic context

Location:: X F1; X 59.1 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (136016146..136022880, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (137115397..137122131, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cytosolic serpins act in a cytoprotective feedback loop that limits ESX-1-dependent death of Mycobacterium marinum-infected macrophages.
Title: Cytosolic serpins act in a cytoprotective feedback loop that limits ESX-1-dependent death of Mycobacterium marinum-infected macrophages.
Use of wild-type and ESX-1-deficient mycobacterial strains demonstrates that mycobacterial type 7 secretion system (T7SS) differentially affects macrophage cell death and interleukin (IL)-1b secretion.
Title: Mycobacterial secretion systems ESX-1 and ESX-5 play distinct roles in host cell death and inflammasome activation.
ESX1 existed in the testes after 3 weeks of age, coincident with the appearance of round spermatids.ESX1 expression became more abundant in the seminiferous tubules as the development of round spermatids progressed into spermatozoa.
Title: Stage-dependent expression of extra-embryonic tissue-spermatogenesis-homeobox gene 1 (ESX1) protein, a candidate marker for X chromosome-bearing sperm.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:495467

NoName (e-PCR)
- UniSTS:484861

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within labyrinthine layer blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within labyrinthine layer morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: homeobox protein ESX1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007957.2 → NP_031983.2 homeobox protein ESX1

See identical proteins and their annotated locations for NP_031983.2

Status: VALIDATED

Source sequence(s)

AF085715

Consensus CDS

CCDS53199.1

UniProtKB/TrEMBL

O88933, Q9Z2U3

Related

ENSMUSP00000074262.3, ENSMUST00000074698.3

Conserved Domains (1) summary

pfam00046
Location:190 → 237

Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

136016146..136022880 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006528498.2 → XP_006528561.1 homeobox protein ESX1 isoform X1

UniProtKB/TrEMBL

A2AG22, O54817

Related

ENSMUSP00000108689.3, ENSMUST00000113066.9

Conserved Domains (1) summary

pfam00046
Location:122 → 170

Homeobox; Homeobox domain