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    Galntl6 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6 [ Mus musculus (house mouse) ]

    Gene ID: 270049, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Galntl6provided by MGI
    Official Full Name
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6provided by MGI
    Primary source
    MGI:MGI:1913581
    See related
    Ensembl:ENSMUSG00000096914 AllianceGenome:MGI:1913581
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A830023L05; 1700021K10Rik; 4930431L04Rik
    Summary
    Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation via threonine. Predicted to be active in Golgi apparatus. Is expressed in eye; facial bone primordium; and nervous system. Orthologous to human GALNTL6 (polypeptide N-acetylgalactosaminyltransferase like 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 2.7), frontal lobe adult (RPKM 1.7) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Galntl6 in Genome Data Viewer
    Location:
    8 B2; 8 30.72 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (58225523..59366213, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (57772489..58912531, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:60058653-60058919 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 7 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_21537 Neighboring gene expressed sequence AW046200 Neighboring gene STARR-seq mESC enhancer starr_21540 Neighboring gene STARR-positive B cell enhancer ABC_E5007 Neighboring gene STARR-seq mESC enhancer starr_21544 Neighboring gene predicted gene 2921 Neighboring gene STARR-seq mESC enhancer starr_21547 Neighboring gene STARR-seq mESC enhancer starr_21548 Neighboring gene predicted gene 15881 Neighboring gene predicted gene, 57526 Neighboring gene STARR-seq mESC enhancer starr_21549 Neighboring gene STARR-seq mESC enhancer starr_21550 Neighboring gene cDNA sequence BC030500 Neighboring gene RuvB-like protein 1 pseudogene Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel human UDP-GalNAc transferase with unique catalytic activity and expression profile. Peng C, et al. Biochem Biophys Res Commun, 2010 Nov 26. PMID 20977886
    2. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article
    3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation via threonine ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    polypeptide N-acetylgalactosaminyltransferase-like 6
    Names
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 20
    NP_778197.2
    XP_017168336.2
    XP_030099456.1
    XP_036009969.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175032.4 → NP_778197.2  polypeptide N-acetylgalactosaminyltransferase-like 6

      See identical proteins and their annotated locations for NP_778197.2

      Status: VALIDATED

      Source sequence(s)
      AC116475, AC116825, AC116875, AC134838, AC135357
      Consensus CDS
      CCDS22318.2
      UniProtKB/TrEMBL
      E5D8G1
      Related
      ENSMUSP00000145321.2, ENSMUST00000204128.3
      Conserved Domains (4) summary
      cd02510
      Location:143 → 438
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      cd00161
      Location:456 → 584
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:454 → 582
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
      pfam10111
      Location:143 → 405
      Glyco_tranf_2_2; Glycosyltransferase like family 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      58225523..59366213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243596.2 → XP_030099456.1  polypeptide N-acetylgalactosaminyltransferase-like 6 isoform X2

      Conserved Domains (2) summary
      cd02510
      Location:237 → 472
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:477 → 602
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    2. XM_017312847.3 → XP_017168336.2  polypeptide N-acetylgalactosaminyltransferase-like 6 isoform X1

      Conserved Domains (2) summary
      cd02510
      Location:237 → 532
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:548 → 676
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    3. XM_036154076.1 → XP_036009969.1  polypeptide N-acetylgalactosaminyltransferase-like 6 isoform X3

      Conserved Domains (1) summary
      cd02510
      Location:237 → 532
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    Nucleotide Protein Strain
    Heading Accession and Version

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