Adgrg7 adhesion G protein-coupled receptor G7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adgrg7provided by MGI
Official Full Name: adhesion G protein-coupled receptor G7provided by MGI
Primary source: MGI:MGI:2441732
See related: Ensembl:ENSMUSG00000022755 AllianceGenome:MGI:2441732
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gpr128; 9130020O16Rik
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in gallbladder; large intestine; and testis. Orthologous to human ADGRG7 (adhesion G protein-coupled receptor G7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in large intestine adult (RPKM 13.6), colon adult (RPKM 8.1) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C1.1; 16 34.22 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (56544972..56616369, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (56724609..56796006, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Based on the crystal structures of ELMO2-RAE and its complex with BAI1 study identified aGPCR-GPR128 as another upstream receptor for the ELMO family scaffolds.
Title: Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds.
Generated a mouse model with a targeted deletion of Gpr128 and found reduced body weight and increased intestinal contraction frequency in this animal model.
Title: Deletion of Gpr128 results in weight loss and increased intestinal contraction frequency.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: adhesion G-protein coupled receptor G7

Names: G protein coupled receptor Gpr128; G protein-coupled receptor 128; probable G-protein coupled receptor 128

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172825.3 → NP_766413.2 adhesion G-protein coupled receptor G7 precursor

See identical proteins and their annotated locations for NP_766413.2

Status: VALIDATED

Source sequence(s)

CT025158

Consensus CDS

CCDS28225.1

UniProtKB/Swiss-Prot

A2RSY9, Q80T42, Q8BM96

Related

ENSMUSP00000023437.5, ENSMUST00000023437.5

Conserved Domains (2) summary

pfam01825
Location:380 → 418

GPS; GPCR proteolysis site, GPS, motif

cl21561
Location:430 → 710

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

56544972..56616369 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011245899.2 → XP_011244201.1 adhesion G-protein coupled receptor G7 isoform X1

Conserved Domains (3) summary

cd14964
Location:430 → 455

7tm_GPCRs; TM helix 1 [structural motif]

pfam01825
Location:380 → 418

GPS; GPCR proteolysis site, GPS, motif

cl28897
Location:428 → 459

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily