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    Impg2 interphotoreceptor matrix proteoglycan 2 [ Mus musculus (house mouse) ]

    Gene ID: 224224, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Impg2provided by MGI
    Official Full Name
    interphotoreceptor matrix proteoglycan 2provided by MGI
    Primary source
    MGI:MGI:3044955
    See related
    Ensembl:ENSMUSG00000035270 AllianceGenome:MGI:3044955
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rsbp; IPM200; PG10.2; Spacrcan
    Summary
    Enables heparin binding activity and hyaluronic acid binding activity. Acts upstream of or within extracellular matrix organization; protein localization; and retina morphogenesis in camera-type eye. Located in interphotoreceptor matrix. Is expressed in embryo; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Used to study retinitis pigmentosa 56 and vitelliform macular dystrophy. Human ortholog(s) of this gene implicated in retinitis pigmentosa 56 and vitelliform macular dystrophy. Orthologous to human IMPG2 (interphotoreceptor matrix proteoglycan 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Impg2 in Genome Data Viewer
    Location:
    16 C1.1; 16 33.91 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (56019447..56094119)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (56203839..56273753)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7467 Neighboring gene STARR-seq mESC enhancer starr_41056 Neighboring gene SUMO1/sentrin specific peptidase 7 Neighboring gene predicted gene, 41462 Neighboring gene STARR-seq mESC enhancer starr_41058 Neighboring gene mitochondrial ribosomal protein L45 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41059 Neighboring gene STARR-seq mESC enhancer starr_41060 Neighboring gene STARR-seq mESC enhancer starr_41061 Neighboring gene STARR-seq mESC enhancer starr_41062 Neighboring gene STARR-seq mESC enhancer starr_41063 Neighboring gene STARR-seq mESC enhancer starr_41064 Neighboring gene discs, large homolog-associated protein 5 pseudogene Neighboring gene ABI family member 3 binding protein Neighboring gene STARR-seq mESC enhancer starr_41065 Neighboring gene STARR-seq mESC enhancer starr_41066 Neighboring gene STARR-seq mESC enhancer starr_41067

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Heterogeneity in the progression of retinal pathologies in mice harboring patient mimicking Impg2 mutations.
      Title: Heterogeneity in the progression of retinal pathologies in mice harboring patient mimicking Impg2 mutations.
    2. Retinal Metabolic Profile on IMPG2 Deficiency Mice with Subretinal Lesions.
      Title: Retinal Metabolic Profile on IMPG2 Deficiency Mice with Subretinal Lesions.
    3. Deletion of the Impg2 gene causes the degeneration of rod and cone cells in mice.
      Title: Deletion of the Impg2 gene causes the degeneration of rod and cone cells in mice.
    4. Proteoglycan IMPG2 Shapes the Interphotoreceptor Matrix and Modulates Vision.
      Title: Proteoglycan IMPG2 Shapes the Interphotoreceptor Matrix and Modulates Vision.
    5. May play an important role in photoreceptor development and maintenance.
      Title: SPACRCAN in the interphotoreceptor matrix of the mouse retina: molecular, developmental and promoter analysis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hyaluronic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hyaluronic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within retina morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular matrix TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in interphotoreceptor matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interphotoreceptor matrix proteoglycan 2
    Names
    sialoprotein associated with cones and rods proteoglycan

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174876.3 → NP_777365.2  interphotoreceptor matrix proteoglycan 2 precursor

      See identical proteins and their annotated locations for NP_777365.2

      Status: VALIDATED

      Source sequence(s)
      AY174061, BC048863
      Consensus CDS
      CCDS37358.1
      UniProtKB/Swiss-Prot
      Q80XH2, Q810Y3, Q8C8E4
      Related
      ENSMUSP00000063648.8, ENSMUST00000069936.8
      Conserved Domains (2) summary
      smart00200
      Location:896 → 1018
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
      cl02507
      Location:235 → 345
      SEA; SEA domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      56019447..56094119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316970.3 → XP_017172459.1  interphotoreceptor matrix proteoglycan 2 isoform X1

      Conserved Domains (2) summary
      smart00200
      Location:862 → 984
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
      cl02507
      Location:201 → 311
      SEA; SEA domain

    2. XM_017316971.3 → XP_017172460.1  interphotoreceptor matrix proteoglycan 2 isoform X2

      Conserved Domains (2) summary
      smart00200
      Location:855 → 977
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
      cl02507
      Location:201 → 304
      SEA; SEA domain

    3. XM_036159902.1 → XP_036015795.1  interphotoreceptor matrix proteoglycan 2 isoform X3

      Conserved Domains (1) summary
      smart00200
      Location:352 → 474
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80XH2.1 GenPept UniProtKB/Swiss-Prot:Q80XH2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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