ANKRD22 ankyrin repeat domain 22 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ANKRD22provided by HGNC
Official Full Name: ankyrin repeat domain 22provided by HGNC
Primary source: HGNC:HGNC:28321
See related: Ensembl:ENSG00000152766 AllianceGenome:HGNC:28321
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression: Biased expression in stomach (RPKM 14.2), skin (RPKM 12.9) and 13 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q23.31

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (88819896..88851844, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (89703828..89735790, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (90579653..90611601, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ANKRD22 knockdown suppresses papillary thyroid cell carcinoma growth and migration and modulates the Wnt/beta-catenin signaling pathway.
Title: ANKRD22 knockdown suppresses papillary thyroid cell carcinoma growth and migration and modulates the Wnt/β-catenin signaling pathway.
ANKRD22 promotes glioma proliferation, migration, invasion, and epithelial-mesenchymal transition by upregulating E2F1-mediated MELK expression.
Title: ANKRD22 promotes glioma proliferation, migration, invasion, and epithelial-mesenchymal transition by upregulating E2F1-mediated MELK expression.
ANKRD22 is an N-myristoylated hairpin-like monotopic membrane protein specifically localized to lipid droplets.
Title: ANKRD22 is an N-myristoylated hairpin-like monotopic membrane protein specifically localized to lipid droplets.
ANKRD22, a novel tumor microenvironment-induced mitochondrial protein promotes metabolic reprogramming of colorectal cancer cells.
Title: ANKRD22, a novel tumor microenvironment-induced mitochondrial protein promotes metabolic reprogramming of colorectal cancer cells.
ANKRD22 exhibits oncogene activity that promotes tumor progression in NSCLC through the transcriptional regulation of E2F1.
Title: ANKRD22 promotes progression of non-small cell lung cancer through transcriptional up-regulation of E2F1.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Observational study of gene-disease association. (HuGE Navigator)
Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-82521 (e-PCR)
- UniSTS:104467

SHGC-57024 (e-PCR)
- UniSTS:33850

SHGC-32791 (e-PCR)
- UniSTS:77526

D20S990 (e-PCR)
- UniSTS:154602

RH47202 (e-PCR)
- UniSTS:80621

General protein information

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Preferred Names: ankyrin repeat domain-containing protein 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144590.3 → NP_653191.2 ankyrin repeat domain-containing protein 22

See identical proteins and their annotated locations for NP_653191.2

Status: VALIDATED

Source sequence(s)

AL353113, BC021671, BM785517, DA672161, N95187

Consensus CDS

CCDS7390.1

UniProtKB/Swiss-Prot

B2R9Y7, Q5VYY1, Q8WU06

Related

ENSP00000360998.4, ENST00000371930.5

Conserved Domains (3) summary

sd00045
Location:39 → 70

ANK; ANK repeat [structural motif]

pfam13637
Location:5 → 60

Ank_4; Ankyrin repeats (many copies)

cl39094
Location:39 → 175

Ank_2; Ankyrin repeats (3 copies)