U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    GORASP2 golgi reassembly stacking protein 2 [ Homo sapiens (human) ]

    Gene ID: 26003, updated on 3-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    GORASP2provided by HGNC
    Official Full Name
    golgi reassembly stacking protein 2provided by HGNC
    Primary source
    HGNC:HGNC:17500
    See related
    Ensembl:ENSG00000115806 MIM:608693; AllianceGenome:HGNC:17500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p59; GRS2; GOLPH6; GRASP55
    Summary
    This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein also plays a role in the intracellular transport of transforming growth factor alpha and may function as a molecular chaperone. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
    Expression
    Ubiquitous expression in thyroid (RPKM 25.6), placenta (RPKM 23.9) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See GORASP2 in Genome Data Viewer
    Location:
    2q31.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (170928477..170967130)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (171405614..171444257)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (171784987..171823640)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ERICH2 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12091 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12092 Neighboring gene glutamate rich 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12093 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_55930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:171674788-171675311 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:171675312-171675834 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:171679351-171680150 Neighboring gene glutamate decarboxylase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16744 Neighboring gene Sharpr-MPRA regulatory region 14 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12094 Neighboring gene uncharacterized LOC124906091 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12096 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:171833995-171834551 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:171840298-171840798 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:171840799-171841299 Neighboring gene NANOG hESC enhancer GRCh37_chr2:171902444-171902951 Neighboring gene tousled like kinase 1 Neighboring gene NANOG hESC enhancer GRCh37_chr2:171959352-171959858 Neighboring gene uncharacterized LOC124906092

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Exploring structural aspects of the human Golgi matrix protein GRASP55 in solution. Reddy ST, et al. Int J Biol Macromol, 2019 Aug 15. PMID 31102680
    2. GRASP55 regulates intra-Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis. Pothukuchi P, et al. EMBO J, 2021 Oct 18. PMID 34516001, Free PMC Article
    3. An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress. Nüchel J, et al. Mol Cell, 2021 Aug 19. PMID 34245671, Free PMC Article
    4. GRASP55: A Multifunctional Protein. Wu H, et al. Curr Protein Pept Sci, 2020. PMID 32067616
    5. Nucleation-dependent amyloid fibrillation of human GRASP55 in aqueous solution. Reddy ST, et al. Eur Biophys J, 2020 Mar. PMID 31915857

    See all (110) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Golgi Reassembly Stacking Protein 2 Modulates Myometrial Contractility during Labor by Affecting ATP Production.
      Title: Golgi Reassembly Stacking Protein 2 Modulates Myometrial Contractility during Labor by Affecting ATP Production.
    2. GRASP depletion-mediated Golgi fragmentation impairs glycosaminoglycan synthesis, sulfation, and secretion.
      Title: GRASP depletion-mediated Golgi fragmentation impairs glycosaminoglycan synthesis, sulfation, and secretion.
    3. GRASP55 regulates intra-Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis.
      Title: GRASP55 regulates intra-Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis.
    4. An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress.
      Title: An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress.
    5. Rapid degradation of GRASP55 and GRASP65 reveals their immediate impact on the Golgi structure.
      Title: Rapid degradation of GRASP55 and GRASP65 reveals their immediate impact on the Golgi structure.
    6. GRASP55: A Multifunctional Protein.
      Title: GRASP55: A Multifunctional Protein.
    7. Nucleation-dependent amyloid fibrillation of human GRASP55 in aqueous solution.
      Title: Nucleation-dependent amyloid fibrillation of human GRASP55 in aqueous solution.
    8. GORASP2/GRASP55 collaborates with the PtdIns3K UVRAG complex to facilitate autophagosome-lysosome fusion.
      Title: GORASP2/GRASP55 collaborates with the PtdIns3K UVRAG complex to facilitate autophagosome-lysosome fusion.
    9. that SIRT2 regulates Golgi structure by modulating GRASP55 acetylation levels
      Title: SIRT2 deacetylates GRASP55 to facilitate post-mitotic Golgi assembly.
    10. here we identified a novel GORASP2-ALK rearrangement in a patient with ALK + LBCL with a unique ALK immunohistochemical staining pattern.
      Title: Identification of a novel GORASP2-ALK fusion in an ALK-positive large B-cell lymphoma.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Phenotypes

    Go to the top of the page Help

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

    Go to the top of the page Help

    Replication interactions

    Interaction Pubs
    Knockdown of golgi reassembly stacking protein 2 (GORASP2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • FLJ13139, DKFZp434D156

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi organization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in establishment of protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in organelle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in organelle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in cis-Golgi network NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Golgi reassembly-stacking protein 2
    Names
    golgi phosphoprotein 6
    golgi reassembly stacking protein 2, 55kDa

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001201428.2 → NP_001188357.1  Golgi reassembly-stacking protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001188357.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC010092, AL117430, BQ004408
      UniProtKB/TrEMBL
      B4DNR1
      Conserved Domains (1) summary
      pfam04495
      Location:1 → 137
      GRASP55_65; GRASP55/65 PDZ-like domain

    2. NM_015530.5 → NP_056345.3  Golgi reassembly-stacking protein 2 isoform 1

      See identical proteins and their annotated locations for NP_056345.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC010092, BC007770, BQ004408
      Consensus CDS
      CCDS33325.1
      UniProtKB/Swiss-Prot
      B4DKT0, Q53TE3, Q96I74, Q96K84, Q9H8Y8, Q9H946, Q9UFW4
      UniProtKB/TrEMBL
      B4DNR1
      Related
      ENSP00000234160.4, ENST00000234160.5
      Conserved Domains (3) summary
      pfam04495
      Location:69 → 205
      GRASP55_65; GRASP55/65 PDZ-like domain
      cl00117
      Location:14 → 100
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cl26464
      Location:241 → 397
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      170928477..170967130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      171405614..171444257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H8Y8.3 GenPept UniProtKB/Swiss-Prot:Q9H8Y8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous