U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    HYOU1 hypoxia up-regulated 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 282295, updated on 17-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    HYOU1provided by VGNC
    Official Full Name
    hypoxia up-regulated 1provided by VGNC
    Primary source
    VGNC:VGNC:50032
    See related
    BGD:BT14870; Ensembl:ENSBTAG00000010322
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    GRP170; ORP150
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See HYOU1 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (29631218..29653246, complement)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex subunit 4 Neighboring gene solute carrier family 37 member 4 Neighboring gene VPS11 core subunit of CORVET and HOPS complexes Neighboring gene hydroxymethylbilane synthase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Comparative analysis of 82 expressed sequence tags from a cattle ovary cDNA library. Ma RZ, et al. Mamm Genome, 1998 Jul. PMID 9657852
    2. Establishment of a high throughput EST sequencing system using poly(A) tail-removed cDNA libraries and determination of 36,000 bovine ESTs. Takasuga A, et al. Nucleic Acids Res, 2001 Nov 15. PMID 11713328, Free PMC Article
    3. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in endoplasmic reticulum unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of endoplasmic reticulum chaperone complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    hypoxia up-regulated protein 1
    Names
    glucose regulated protein, 170 kDa
    oxygen regulated protein, 150 kDa

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206910.1 → NP_001193839.1  hypoxia up-regulated protein 1 precursor

      See identical proteins and their annotated locations for NP_001193839.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AV667435, BE722782, CB443436, CK772437, CN435952, DN546651, DT809461, DV883195, DV888816, EV694702
      UniProtKB/TrEMBL
      A0A3Q1M1A5
      Related
      ENSBTAP00000064965.2, ENSBTAT00000072953.2
      Conserved Domains (3) summary
      cd10230
      Location:36 → 424
      HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
      PHA03169
      Location:587 → 698
      PHA03169; hypothetical protein; Provisional
      cl26761
      Location:554 → 797
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    2. NM_001206911.1 → NP_001193840.1  hypoxia up-regulated protein 1 precursor

      See identical proteins and their annotated locations for NP_001193840.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AV667435, CB443436, CK772437, CN435952, DN546651, DV883195, DV888816, EV650393, EV694702
      UniProtKB/TrEMBL
      A0A3Q1M1A5
      Conserved Domains (3) summary
      cd10230
      Location:36 → 424
      HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
      PHA03169
      Location:587 → 698
      PHA03169; hypothetical protein; Provisional
      cl26761
      Location:554 → 797
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      29631218..29653246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005215907.5 → XP_005215964.1  hypoxia up-regulated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005215964.1

      UniProtKB/TrEMBL
      A0A3Q1M1A5, A0A3Q1MBP1
      Conserved Domains (3) summary
      cd10230
      Location:36 → 424
      HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
      COG0443
      Location:38 → 669
      DnaK; Molecular chaperone DnaK (HSP70) [Posttranslational modification, protein turnover, chaperones]
      pfam06459
      Location:549 → 697
      RR_TM4-6; Ryanodine Receptor TM 4-6

    2. XM_005215906.5 → XP_005215963.1  hypoxia up-regulated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005215963.1

      UniProtKB/TrEMBL
      A0A3Q1M1A5, A0A3Q1MBP1
      Related
      ENSBTAP00000074586.2, ENSBTAT00000066893.2
      Conserved Domains (3) summary
      cd10230
      Location:36 → 424
      HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
      COG0443
      Location:38 → 669
      DnaK; Molecular chaperone DnaK (HSP70) [Posttranslational modification, protein turnover, chaperones]
      pfam06459
      Location:549 → 697
      RR_TM4-6; Ryanodine Receptor TM 4-6

    3. XM_005215905.5 → XP_005215962.1  hypoxia up-regulated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005215962.1

      UniProtKB/TrEMBL
      A0A3Q1M1A5, A0A3Q1MBP1
      Related
      ENSBTAP00000066108.2, ENSBTAT00000075055.2
      Conserved Domains (3) summary
      cd10230
      Location:36 → 424
      HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
      COG0443
      Location:38 → 669
      DnaK; Molecular chaperone DnaK (HSP70) [Posttranslational modification, protein turnover, chaperones]
      pfam06459
      Location:549 → 697
      RR_TM4-6; Ryanodine Receptor TM 4-6

    4. XM_024975023.2 → XP_024830791.1  hypoxia up-regulated protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1M1A5
      Conserved Domains (3) summary
      cd10230
      Location:36 → 424
      HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
      PHA03169
      Location:587 → 698
      PHA03169; hypothetical protein; Provisional
      cl26761
      Location:554 → 797
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    5. XM_010812420.4 → XP_010810722.1  hypoxia up-regulated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_010810722.1

      UniProtKB/TrEMBL
      A0A3Q1M1A5, A0A3Q1MBP1
      Conserved Domains (3) summary
      cd10230
      Location:36 → 424
      HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
      COG0443
      Location:38 → 669
      DnaK; Molecular chaperone DnaK (HSP70) [Posttranslational modification, protein turnover, chaperones]
      pfam06459
      Location:549 → 697
      RR_TM4-6; Ryanodine Receptor TM 4-6
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials