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    PHLDB1 pleckstrin homology like domain family B member 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 533996, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PHLDB1provided by VGNC
    Official Full Name
    pleckstrin homology like domain family B member 1provided by VGNC
    Primary source
    VGNC:VGNC:32837
    See related
    BGD:BT13763; Ensembl:ENSBTAG00000016197
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PHLDB1 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (29261940..29310613)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene microRNA mir-2285ak Neighboring gene intraflagellar transport 46 Neighboring gene archain 1 Neighboring gene microRNA mir-12011 Neighboring gene trehalase Neighboring gene DEAD-box helicase 6 Neighboring gene CBY1-interacting BAR domain-containing protein 1-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basal cortex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pleckstrin homology-like domain family B member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206042.2 → NP_001192971.1  pleckstrin homology-like domain family B member 1

      See identical proteins and their annotated locations for NP_001192971.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000015
      UniProtKB/TrEMBL
      A0A3Q1MN58
      Related
      ENSBTAP00000073320.2, ENSBTAT00000079193.2
      Conserved Domains (8) summary
      cd14673
      Location:1258 → 1373
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1261 → 1368
      PH; PH domain
      pfam00498
      Location:64 → 124
      FHA; FHA domain
      pfam10473
      Location:679 → 806
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam14988
      Location:729 → 934
      DUF4515; Domain of unknown function (DUF4515)
      cd16269
      Location:776 → 789
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:695 → 900
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:717 → 804
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      29261940..29310613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005215996.5 → XP_005216053.1  pleckstrin homology-like domain family B member 1 isoform X1

      See identical proteins and their annotated locations for XP_005216053.1

      UniProtKB/TrEMBL
      G3N336
      Conserved Domains (6) summary
      cd14673
      Location:1422 → 1537
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1425 → 1532
      PH; PH domain
      pfam00498
      Location:64 → 124
      FHA; FHA domain
      pfam10473
      Location:679 → 822
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      cl09111
      Location:687 → 759
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
      cl23750
      Location:742 → 843
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    2. XM_010812483.4 → XP_010810785.1  pleckstrin homology-like domain family B member 1 isoform X2

      UniProtKB/TrEMBL
      G3N336
      Conserved Domains (6) summary
      cd14673
      Location:1422 → 1526
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1425 → 1521
      PH; PH domain
      pfam00498
      Location:64 → 124
      FHA; FHA domain
      pfam10473
      Location:679 → 822
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      cl09111
      Location:687 → 759
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
      cl23750
      Location:742 → 843
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    3. XM_010812484.4 → XP_010810786.1  pleckstrin homology-like domain family B member 1 isoform X3

      UniProtKB/TrEMBL
      G3N336
      Conserved Domains (6) summary
      cd14673
      Location:1407 → 1522
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1410 → 1517
      PH; PH domain
      pfam00498
      Location:64 → 124
      FHA; FHA domain
      pfam10473
      Location:679 → 822
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      cl09111
      Location:687 → 759
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
      cl23750
      Location:742 → 843
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    4. XM_024975344.2 → XP_024831112.1  pleckstrin homology-like domain family B member 1 isoform X4

      UniProtKB/TrEMBL
      G3N336
      Conserved Domains (5) summary
      cd14673
      Location:1407 → 1511
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00498
      Location:64 → 124
      FHA; FHA domain
      cl25545
      Location:1178 → 1216
      V-ATPase_G_2; Vacuolar (H+)-ATPase G subunit
      cl25732
      Location:711 → 943
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26464
      Location:150 → 474
      Atrophin-1; Atrophin-1 family

    5. XM_005215999.5 → XP_005216056.1  pleckstrin homology-like domain family B member 1 isoform X7

      UniProtKB/TrEMBL
      G3N336
      Conserved Domains (6) summary
      cd14673
      Location:1364 → 1479
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1367 → 1474
      PH; PH domain
      pfam00498
      Location:64 → 124
      FHA; FHA domain
      pfam10473
      Location:679 → 822
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      cl09111
      Location:687 → 759
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
      cl23750
      Location:742 → 843
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    6. XM_015474658.3 → XP_015330144.1  pleckstrin homology-like domain family B member 1 isoform X6

      UniProtKB/TrEMBL
      G3N336
      Conserved Domains (6) summary
      cd14673
      Location:1374 → 1489
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1377 → 1484
      PH; PH domain
      pfam00498
      Location:64 → 124
      FHA; FHA domain
      pfam10473
      Location:679 → 822
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      cl09111
      Location:687 → 759
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
      cl23750
      Location:742 → 843
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    7. XM_005216002.5 → XP_005216059.1  pleckstrin homology-like domain family B member 1 isoform X8

      UniProtKB/TrEMBL
      G3N336
      Conserved Domains (7) summary
      COG1196
      Location:711 → 1276
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1316 → 1431
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1319 → 1426
      PH; PH domain
      pfam00498
      Location:64 → 124
      FHA; FHA domain
      pfam10473
      Location:679 → 822
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      cl09111
      Location:687 → 759
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
      cl23750
      Location:742 → 843
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    8. XM_005216003.5 → XP_005216060.1  pleckstrin homology-like domain family B member 1 isoform X10

      UniProtKB/TrEMBL
      G3N336
      Related
      ENSBTAP00000056309.3, ENSBTAT00000064299.3
      Conserved Domains (7) summary
      COG1196
      Location:711 → 1261
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1301 → 1416
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1304 → 1411
      PH; PH domain
      pfam00498
      Location:64 → 124
      FHA; FHA domain
      pfam10473
      Location:679 → 822
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      cl09111
      Location:687 → 759
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
      cl23750
      Location:742 → 843
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    9. XM_005216005.5 → XP_005216062.1  pleckstrin homology-like domain family B member 1 isoform X12

      UniProtKB/TrEMBL
      A0A3Q1M6V5
      Conserved Domains (6) summary
      cd14673
      Location:1269 → 1384
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1272 → 1379
      PH; PH domain
      pfam00498
      Location:64 → 124
      FHA; FHA domain
      pfam10473
      Location:679 → 822
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      cl09111
      Location:687 → 759
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
      cl23750
      Location:742 → 843
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    10. XM_005216006.5 → XP_005216063.1  pleckstrin homology-like domain family B member 1 isoform X13

      UniProtKB/TrEMBL
      A0A3Q1M6V5
      Related
      ENSBTAP00000064094.2, ENSBTAT00000073717.2
      Conserved Domains (6) summary
      cd14673
      Location:1254 → 1369
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1257 → 1364
      PH; PH domain
      pfam00498
      Location:64 → 124
      FHA; FHA domain
      pfam10473
      Location:679 → 822
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      cl09111
      Location:687 → 759
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
      cl23750
      Location:742 → 843
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    11. XM_010812485.4 → XP_010810787.1  pleckstrin homology-like domain family B member 1 isoform X5

      UniProtKB/TrEMBL
      A0A3Q1MN58
      Conserved Domains (7) summary
      cd14673
      Location:1379 → 1494
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1382 → 1489
      PH; PH domain
      pfam00498
      Location:64 → 124
      FHA; FHA domain
      pfam10473
      Location:679 → 806
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      cd16269
      Location:776 → 789
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:695 → 900
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:717 → 804
      GBP_C; Guanylate-binding protein, C-terminal domain

    12. XM_005216004.5 → XP_005216061.1  pleckstrin homology-like domain family B member 1 isoform X11

      UniProtKB/TrEMBL
      A0A3Q1MN58
      Conserved Domains (8) summary
      cd14673
      Location:1273 → 1388
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1276 → 1383
      PH; PH domain
      pfam00498
      Location:64 → 124
      FHA; FHA domain
      pfam10473
      Location:679 → 806
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam14988
      Location:729 → 934
      DUF4515; Domain of unknown function (DUF4515)
      cd16269
      Location:776 → 789
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:695 → 900
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:717 → 804
      GBP_C; Guanylate-binding protein, C-terminal domain

    13. XM_010812487.4 → XP_010810789.1  pleckstrin homology-like domain family B member 1 isoform X14

      UniProtKB/TrEMBL
      A0A3Q1MN58
      Conserved Domains (8) summary
      cd14673
      Location:1258 → 1362
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1261 → 1357
      PH; PH domain
      pfam00498
      Location:64 → 124
      FHA; FHA domain
      pfam10473
      Location:679 → 806
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam14988
      Location:729 → 934
      DUF4515; Domain of unknown function (DUF4515)
      cd16269
      Location:776 → 789
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:695 → 900
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:717 → 804
      GBP_C; Guanylate-binding protein, C-terminal domain

    14. XM_005216007.4 → XP_005216064.1  pleckstrin homology-like domain family B member 1 isoform X15

      UniProtKB/TrEMBL
      G3MXU7
      Related
      ENSBTAP00000054368.3, ENSBTAT00000065315.3
      Conserved Domains (7) summary
      cd14673
      Location:1226 → 1341
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1229 → 1336
      PH; PH domain
      pfam00498
      Location:64 → 124
      FHA; FHA domain
      pfam10473
      Location:679 → 806
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      cd16269
      Location:776 → 789
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:695 → 900
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:717 → 804
      GBP_C; Guanylate-binding protein, C-terminal domain

    15. XM_005216008.5 → XP_005216065.1  pleckstrin homology-like domain family B member 1 isoform X16

      UniProtKB/TrEMBL
      G3MXU7
      Conserved Domains (7) summary
      cd14673
      Location:1211 → 1315
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1214 → 1310
      PH; PH domain
      pfam00498
      Location:64 → 124
      FHA; FHA domain
      pfam10473
      Location:679 → 806
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      cd16269
      Location:776 → 789
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:695 → 900
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:717 → 804
      GBP_C; Guanylate-binding protein, C-terminal domain

    16. XM_010812482.4 → XP_010810784.1  pleckstrin homology-like domain family B member 1 isoform X1

      See identical proteins and their annotated locations for XP_010810784.1

      UniProtKB/TrEMBL
      G3N336
      Conserved Domains (6) summary
      cd14673
      Location:1422 → 1537
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1425 → 1532
      PH; PH domain
      pfam00498
      Location:64 → 124
      FHA; FHA domain
      pfam10473
      Location:679 → 822
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      cl09111
      Location:687 → 759
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
      cl23750
      Location:742 → 843
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    17. XM_010812486.3 → XP_010810788.1  pleckstrin homology-like domain family B member 1 isoform X9

      UniProtKB/TrEMBL
      A0A3Q1LQW2
      Related
      ENSBTAP00000062601.2, ENSBTAT00000078919.2
      Conserved Domains (5) summary
      cd14673
      Location:1302 → 1417
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1305 → 1412
      PH; PH domain
      pfam10473
      Location:559 → 702
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      cl09111
      Location:567 → 639
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
      cl23750
      Location:622 → 723
      vATP-synt_E; ATP synthase (E/31 kDa) subunit
    Nucleotide Protein Strain
    Heading Accession and Version

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