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    VPS11 VPS11 core subunit of CORVET and HOPS complexes [ Bos taurus (domestic cattle) ]

    Gene ID: 540381, updated on 17-Aug-2024

    Summary

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    Official Symbol
    VPS11provided by VGNC
    Official Full Name
    VPS11 core subunit of CORVET and HOPS complexesprovided by VGNC
    Primary source
    VGNC:VGNC:36809
    See related
    BGD:BT19063; Ensembl:ENSBTAG00000005357
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See VPS11 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (29653337..29663614)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 37 member 4 Neighboring gene hypoxia up-regulated 1 Neighboring gene hydroxymethylbilane synthase Neighboring gene H2A.X variant histone

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC137371

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endosome organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in organelle fusion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vacuole organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vesicle docking involved in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of HOPS complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vacuolar protein sorting-associated protein 11 homolog
    Names
    VPS11, CORVET/HOPS core subunit
    vacuolar protein sorting 11 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076216.2 → NP_001069684.1  vacuolar protein sorting-associated protein 11 homolog

      See identical proteins and their annotated locations for NP_001069684.1

      Status: PROVISIONAL

      Source sequence(s)
      BC114084
      UniProtKB/TrEMBL
      A0A3Q1NH51, Q24K07
      Related
      ENSBTAP00000071235.2, ENSBTAT00000078435.2
      Conserved Domains (5) summary
      smart00299
      Location:411 → 535
      CLH; Clathrin heavy chain repeat homology
      cd00162
      Location:821 → 860
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam00637
      Location:417 → 536
      Clathrin; Region in Clathrin and VPS
      pfam12451
      Location:862 → 907
      VPS11_C; Vacuolar protein sorting protein 11 C terminal
      cl02567
      Location:142 → 292
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      29653337..29663614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024975463.2 → XP_024831231.1  vacuolar protein sorting-associated protein 11 homolog isoform X2

      UniProtKB/TrEMBL
      A0A3Q1NH51
      Related
      ENSBTAP00000088613.1, ENSBTAT00000104093.1
      Conserved Domains (4) summary
      pfam00637
      Location:358 → 477
      Clathrin; Region in Clathrin and VPS
      pfam12451
      Location:805 → 848
      VPS11_C; Vacuolar protein sorting protein 11 C terminal
      cd16688
      Location:761 → 804
      RING-H2_Vps11; RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 11 homolog (Vps11) and similar proteins
      cl25539
      Location:83 → 233
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_010812509.4 → XP_010810811.2  vacuolar protein sorting-associated protein 11 homolog isoform X1

      UniProtKB/TrEMBL
      A0A3Q1NH51, F1N5Q5
      Related
      ENSBTAP00000007042.4, ENSBTAT00000007042.5
      Conserved Domains (4) summary
      pfam00637
      Location:421 → 540
      Clathrin; Region in Clathrin and VPS
      pfam12451
      Location:868 → 911
      VPS11_C; Vacuolar protein sorting protein 11 C terminal
      cd16688
      Location:824 → 867
      RING-H2_Vps11; RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 11 homolog (Vps11) and similar proteins
      cl25539
      Location:146 → 296
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Research Materials