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    Prc1 protein regulator of cytokinesis 1 [ Mus musculus (house mouse) ]

    Gene ID: 233406, updated on 11-Nov-2024

    Summary

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    Official Symbol
    Prc1provided by MGI
    Official Full Name
    protein regulator of cytokinesis 1provided by MGI
    Primary source
    MGI:MGI:1858961
    See related
    Ensembl:ENSMUSG00000038943 AllianceGenome:MGI:1858961
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D7Ertd348e
    Summary
    Predicted to enable cytoskeletal protein binding activity; identical protein binding activity; and protein kinase binding activity. Predicted to be involved in mitotic spindle midzone assembly; positive regulation of cell population proliferation; and regulation of cytokinesis. Predicted to act upstream of or within microtubule bundle formation. Predicted to be located in several cellular components, including contractile ring; intercellular bridge; and midbody. Predicted to be active in cytoplasm and mitotic spindle midzone. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human PRC1 (protein regulator of cytokinesis 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 31.2), liver E14 (RPKM 29.8) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prc1 in Genome Data Viewer
    Location:
    7 D2; 7 45.62 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79944224..79966007)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80294445..80316259)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2826 Neighboring gene neugrin, neurite outgrowth associated Neighboring gene vacuolar protein sorting 33B Neighboring gene STARR-positive B cell enhancer ABC_E2827 Neighboring gene RCC1 domain containing 1 Neighboring gene unc-45 myosin chaperone A Neighboring gene STARR-positive B cell enhancer ABC_E2828 Neighboring gene STARR-positive B cell enhancer ABC_E6566 Neighboring gene HD domain containing 3 Neighboring gene high mobility group box 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dual role of Med12 in PRC1-dependent gene repression and ncRNA-mediated transcriptional activation. Papadopoulou T, et al. Cell Cycle, 2016 Jun 2. PMID 27096886, Free PMC Article
    2. Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin. Zhen CY, et al. Elife, 2016 Oct 10. PMID 27723458, Free PMC Article
    3. Cdk1 negatively regulates the spindle localization of Prc1 in mouse oocytes. Nishiyama S, et al. Genes Cells, 2020 Oct. PMID 32865279
    4. PRC1 is a critical regulator for anaphase spindle midzone assembly and cytokinesis in mouse oocyte meiosis. Li XH, et al. FEBS J, 2021 May. PMID 33206458
    5. RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin compaction mediate propagation of H2AK119ub1 during cell division. Zhao J, et al. Nat Cell Biol, 2020 Apr. PMID 32203418

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages.
      Title: Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages.
    2. PRC1 is a critical regulator for anaphase spindle midzone assembly and cytokinesis in mouse oocyte meiosis.
      Title: PRC1 is a critical regulator for anaphase spindle midzone assembly and cytokinesis in mouse oocyte meiosis.
    3. Cdk1 negatively regulates the spindle localization of Prc1 in mouse oocytes.
      Title: Cdk1 negatively regulates the spindle localization of Prc1 in mouse oocytes.
    4. Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes.
      Title: Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes.
    5. The results suggest that histone H1-dependent chromatin compaction plays a critical role in the stable propagation of H2AK119ub1 by RYBP/YAF2-PRC1 during cell division.
      Title: RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin compaction mediate propagation of H2AK119ub1 during cell division.
    6. Results indicate that Ub-independent mode of repression by PRC1 plays a key role in mammalian development during cell fate restriction.
      Title: Ubiquitination-Independent Repression of PRC1 Targets during Neuronal Fate Restriction in the Developing Mouse Neocortex.
    7. Authors analyzed whether elevated levels of the polycomb repressor complex 1 (PRC1) components Bmi1 and Ring1b and their catalyzed histone modification H2AK119ub in ADMs and tumor cells, are responsible for the mediation of acinar gene silencing.
      Title: Polycomb repressor complex 1 promotes gene silencing through H2AK119 mono-ubiquitination in acinar-to-ductal metaplasia and pancreatic cancer cells.
    8. Here, the authors discover that the histone H2AK119 E3 ubiquitin ligase activity of Polycomb repressive complex 1 (PRC1) is defined by the composition of its catalytic subunits and is highly regulated by RYBP/YAF2-dependent stimulation.
      Title: RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes.
    9. Here, by combining live-cell single-molecule tracking (SMT) and genetic engineering, the authors reveal that H3K27me3 contributes significantly to the targeting of Cbx7-PRC1 complex to chromatin.
      Title: Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin.
    10. Pcgf6 is essential for recruitment of PRC1.6 to chromatin. Our results reveal a previously uncharacterized, H2AK119ub1-independent chromatin assembly associated with PRC1.6 complex
      Title: Essential Role for Polycomb Group Protein Pcgf6 in Embryonic Stem Cell Maintenance and a Noncanonical Polycomb Repressive Complex 1 (PRC1) Integrity.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC6745

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within microtubule bundle formation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle midzone assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in contractile ring ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in contractile ring ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitotic spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein regulator of cytokinesis 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285997.2 → NP_001272926.1  protein regulator of cytokinesis 1 isoform 2

      See identical proteins and their annotated locations for NP_001272926.1

      Status: VALIDATED

      Source sequence(s)
      AC109232, AC136740
      Consensus CDS
      CCDS71985.1
      UniProtKB/Swiss-Prot
      E9QPF0, Q8CE25, Q99K43
      UniProtKB/TrEMBL
      G3XA79
      Related
      ENSMUSP00000043379.8, ENSMUST00000047558.14
      Conserved Domains (2) summary
      pfam03999
      Location:37 → 598
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      pfam13094
      Location:34 → 130
      CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit

    2. NM_001285998.2 → NP_001272927.1  protein regulator of cytokinesis 1 isoform 3

      See identical proteins and their annotated locations for NP_001272927.1

      Status: VALIDATED

      Source sequence(s)
      AC109232, AC136740
      Consensus CDS
      CCDS71986.1
      UniProtKB/TrEMBL
      G3UY19, G3XA79
      Related
      ENSMUSP00000133910.2, ENSMUST00000173824.8
      Conserved Domains (1) summary
      pfam03999
      Location:37 → 560
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

    3. NM_001374624.1 → NP_001361553.1  protein regulator of cytokinesis 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (4).
      Source sequence(s)
      AC109232, AC136740
      Consensus CDS
      CCDS90258.1
      UniProtKB/TrEMBL
      G3UWQ7, G3XA79
      Related
      ENSMUSP00000133387.2, ENSMUST00000174172.8
      Conserved Domains (1) summary
      pfam03999
      Location:37 → 615
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

    4. NM_001382385.1 → NP_001369314.1  protein regulator of cytokinesis 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC109232, AC136740
      UniProtKB/TrEMBL
      G3XA79
      Conserved Domains (1) summary
      pfam03999
      Location:37 → 549
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

    5. NM_001382386.1 → NP_001369315.1  protein regulator of cytokinesis 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC109232, AC136740
      UniProtKB/TrEMBL
      G3XA79
      Conserved Domains (1) summary
      pfam03999
      Location:1 → 496
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

    6. NM_001382387.1 → NP_001369316.1  protein regulator of cytokinesis 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC109232, AC136740
      UniProtKB/TrEMBL
      G3XA79
      Conserved Domains (1) summary
      pfam03999
      Location:37 → 517
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

    7. NM_001382388.1 → NP_001369317.1  protein regulator of cytokinesis 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC109232, AC136740
      UniProtKB/TrEMBL
      G3XA79
      Conserved Domains (1) summary
      pfam03999
      Location:37 → 612
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

    8. NM_001382389.1 → NP_001369318.1  protein regulator of cytokinesis 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC109232, AC136740
      UniProtKB/TrEMBL
      G3XA79
      Conserved Domains (1) summary
      pfam03999
      Location:37 → 614
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

    9. NM_001382390.1 → NP_001369319.1  protein regulator of cytokinesis 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC109232, AC136740
      UniProtKB/TrEMBL
      G3XA79
      Conserved Domains (1) summary
      pfam03999
      Location:1 → 440
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

    10. NM_001420434.1 → NP_001407363.1  protein regulator of cytokinesis 1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC109232, AC136740

    11. NM_145150.4 → NP_660132.2  protein regulator of cytokinesis 1 isoform 1

      See identical proteins and their annotated locations for NP_660132.2

      Status: VALIDATED

      Source sequence(s)
      AC109232, AC136740
      Consensus CDS
      CCDS39998.2
      UniProtKB/TrEMBL
      G3UW86, G3XA79
      Related
      ENSMUSP00000129675.3, ENSMUST00000163812.9
      Conserved Domains (2) summary
      pfam03999
      Location:37 → 601
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      pfam13094
      Location:34 → 130
      CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      79944224..79966007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99K43.2 GenPept UniProtKB/Swiss-Prot:Q99K43

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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