Ngrn neugrin, neurite outgrowth associated [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ngrnprovided by MGI
Official Full Name: neugrin, neurite outgrowth associatedprovided by MGI
Primary source: MGI:MGI:1933212
See related: Ensembl:ENSMUSG00000047084 AllianceGenome:MGI:1933212
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable rRNA binding activity. Predicted to be involved in mitochondrial ribosome assembly and positive regulation of mitochondrial translation. Located in nucleus. Is expressed in several structures, including brain; heart; liver; metanephros; and spinal cord ventral horn. Orthologous to human NGRN (neugrin, neurite outgrowth associated). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 19.2), CNS E18 (RPKM 18.2) and 28 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 7 D2; 7 45.58 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (79910963..79915126)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (80261215..80265378)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

General gene information

Go to the top of the page Help

Markers

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

AW552001 (e-PCR)
- UniSTS:179595

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables rRNA binding	ISO Inferred from Sequence Orthology more info
enables rRNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial ribosome assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial ribosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitochondrial translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial translation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: neugrin

Names: FI58Gm; m-Neugrin; neurite outgrowth-associated protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031375.4 → NP_113552.3 neugrin precursor

See identical proteins and their annotated locations for NP_113552.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) encodes the functional protein.

Source sequence(s)

AC109232, AI506588, AK083330, CJ154012

Consensus CDS

CCDS21393.2

UniProtKB/Swiss-Prot

Q8C401, Q99KS2, Q99PU9

Related

ENSMUSP00000113444.2, ENSMUST00000117989.2

Conserved Domains (1) summary

pfam06413
Location:73 → 293

Neugrin; Neugrin

RNA

NR_028053.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (1) retains an intron in the 5' coding region, compared to variant 2. This variant is represented as non-coding because translation would be expected to begin at the 5'-most translation start codon, as used in variant 1, which has a strong Kozak signal. However, translation from this start site renders the transcript a candidate for nonsense-mediated mRNA decay (NMD), so it is not clear which, if any, protein may be expressed from this variant.

Source sequence(s)

AC109232, AI506588, AK083330

Related

ENSMUST00000138005.2