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    Clca2 chloride channel accessory 2 [ Mus musculus (house mouse) ]

    Gene ID: 229933, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Clca2provided by MGI
    Official Full Name
    chloride channel accessory 2provided by MGI
    Primary source
    MGI:MGI:2139758
    See related
    Ensembl:ENSMUSG00000036960 AllianceGenome:MGI:2139758
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clca5; 4732440A06
    Summary
    This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. Mice lacking a functional copy of this gene exhibit increased liver weight and hepatocyte hypertrophy. [provided by RefSeq, Sep 2016]
    Expression
    Biased expression in bladder adult (RPKM 1.1), subcutaneous fat pad adult (RPKM 0.8) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Clca2 in Genome Data Viewer
    Location:
    3 H2; 3 69.31 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (144776021..144805204, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (145070260..145099443, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene chloride channel accessory 4A Neighboring gene predicted gene, 35066 Neighboring gene STARR-seq mESC enhancer starr_09188 Neighboring gene chloride channel accessory 1 Neighboring gene STARR-seq mESC enhancer starr_09190 Neighboring gene STARR-seq mESC enhancer starr_09191 Neighboring gene STARR-positive B cell enhancer ABC_E1637 Neighboring gene predicted gene, 40163 Neighboring gene STARR-positive B cell enhancer mm9_chr3:144794197-144794498 Neighboring gene outer dense fiber of sperm tails 2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Re-expression of detachment-inducible chloride channel mCLCA5 suppresses growth of metastatic breast cancer cells. Beckley JR, et al. J Biol Chem, 2004 Oct 1. PMID 15292178
    2. Murine mCLCA5 is expressed in granular layer keratinocytes of stratified epithelia. Braun J, et al. Histochem Cell Biol, 2010 Mar. PMID 20012443
    3. Stat3 modulates chloride channel accessory protein expression in normal and neoplastic mammary tissue. Hughes K, et al. Cell Death Dis, 2016 Oct 6. PMID 27711075, Free PMC Article
    4. NF-κB-regulated transcriptional control of CLCA in a differentiated mouse keratinocyte line. Hiromatsu R, et al. J Dermatol Sci, 2015 Jun. PMID 25828855
    5. Humidity-regulated CLCA2 protects the epidermis from hyperosmotic stress. Seltmann K, et al. Sci Transl Med, 2018 May 9. PMID 29743348

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CLCA2 knockdown promoted keratinocyte apoptosis induced by hyperosmotic stress through impairment of cell-cell adhesion.
      Title: Humidity-regulated CLCA2 protects the epidermis from hyperosmotic stress.
    2. Stat3-mediated regulation of expression of members of the calcium-activated chloride channel regulator (CLCA) family of proteins during involution and mammary carcinogenesis.
      Title: Stat3 modulates chloride channel accessory protein expression in normal and neoplastic mammary tissue.
    3. basal NF-kappaB activity is involved in the Ca(2+)-dependent regulation of mCLCA2 expression in a mouse keratinocyte line
      Title: NF-κB-regulated transcriptional control of CLCA in a differentiated mouse keratinocyte line.
    4. The results imply that mCLCA5 may play a role in maturation and keratinization of squamous epithelial cells.
      Title: Murine mCLCA5 is expressed in granular layer keratinocytes of stratified epithelia.
    5. results establish mCLCA5 as the mouse ortholog of hCLCA2, demonstrate that mCLCA5 is a detachment-sensitive growth inhibitor, and suggest a mechanism whereby these channels may antagonize mammary tumor progression, metastases [CLCA5]
      Title: Re-expression of detachment-inducible chloride channel mCLCA5 suppresses growth of metastatic breast cancer cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chloride channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables intracellularly calcium-gated chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intracellularly calcium-gated chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligand-gated monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ligand-gated monoatomic ion channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chloride transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in basal plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calcium-activated chloride channel regulator 2
    Names
    calcium-activated chloride channel family member 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001409792.1 → NP_001396721.1  calcium-activated chloride channel regulator 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC152400
      Related
      ENSMUSP00000143161.2, ENSMUST00000198993.2

    2. NM_178697.6 → NP_848812.1  calcium-activated chloride channel regulator 2 isoform 1

      See identical proteins and their annotated locations for NP_848812.1

      Status: REVIEWED

      Source sequence(s)
      AC152400
      Consensus CDS
      CCDS17890.1
      UniProtKB/Swiss-Prot
      Q8BG22, Q8BZF7
      Related
      ENSMUSP00000036029.7, ENSMUST00000040465.11
      Conserved Domains (2) summary
      cd00198
      Location:310 → 466
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam08434
      Location:34 → 893
      CLCA; Calcium-activated chloride channel

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      144776021..144805204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501432.4 → XP_006501495.1  calcium-activated chloride channel regulator 2 isoform X1

      Conserved Domains (1) summary
      TIGR00868
      Location:1 → 818
      hCaCC; calcium-activated chloride channel protein 1

    2. XM_006501433.1 → XP_006501496.1  calcium-activated chloride channel regulator 2 isoform X2

      Conserved Domains (1) summary
      TIGR00868
      Location:11 → 689
      hCaCC; calcium-activated chloride channel protein 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BG22.1 GenPept UniProtKB/Swiss-Prot:Q8BG22

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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