Cmpk1 cytidine/uridine monophosphate kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cmpk1provided by MGI
Official Full Name: cytidine/uridine monophosphate kinase 1provided by MGI
Primary source: MGI:MGI:1913838
See related: Ensembl:ENSMUSG00000028719 AllianceGenome:MGI:1913838
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CK; Cmpk; UMP-CMPk; 0610011D08Rik
Summary: Predicted to enable CMP kinase activity; UMP kinase activity; and nucleoside diphosphate kinase activity. Predicted to be involved in pyrimidine nucleoside diphosphate biosynthetic process. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including heart; nervous system; respiratory system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human CMPK1 (cytidine/uridine monophosphate kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 43.9), colon adult (RPKM 37.4) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D1; 4 52.73 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (114817810..114844425, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (114960613..114987228, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables (d)CMP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables CMP kinase activity	IEA Inferred from Electronic Annotation more info
enables CMP kinase activity	ISO Inferred from Sequence Orthology more info
enables UMP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UMP kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables UMP/dUMP kinase activity	ISO Inferred from Sequence Orthology more info
enables dCMP kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	ISO Inferred from Sequence Orthology more info
enables nucleoside diphosphate kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleoside monophosphate kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in CDP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in CDP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in UDP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in UDP biosynthetic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in dCDP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in dUDP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in nucleoside monophosphate phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: UMP-CMP kinase

Names: UMP/CMPK; cytidine monophosphate (UMP-CMP) kinase 1; cytidine monophosphate kinase; cytidylate kinase 1; dCMP kinase; deoxycytidylate kinase; likely ortholog of H. sapiens UMP-CMP kinase (UMP-CMPK); nucleoside-diphosphate kinase; uridine monophosphate kinase; uridine monophosphate/cytidine monophosphate kinase

NP_079923.3

EC 2.7.4.14

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025647.3 → NP_079923.3 UMP-CMP kinase

See identical proteins and their annotated locations for NP_079923.3

Status: VALIDATED

Source sequence(s)

AK002526, AK077534, AK150162, AV315242

Consensus CDS

CCDS18484.1

UniProtKB/Swiss-Prot

Q8BK17, Q8VD05, Q9DBP5, Q9DCS7

UniProtKB/TrEMBL

A0A0R4J093

Related

ENSMUSP00000030491.9, ENSMUST00000030491.9

Conserved Domains (2) summary

cd01428
Location:36 → 215

ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

TIGR01359
Location:36 → 224

UMP_CMP_kin_fam; UMP-CMP kinase family