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    Psmd11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 [ Mus musculus (house mouse) ]

    Gene ID: 69077, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Psmd11provided by MGI
    Official Full Name
    proteasome (prosome, macropain) 26S subunit, non-ATPase, 11provided by MGI
    Primary source
    MGI:MGI:1916327
    See related
    Ensembl:ENSMUSG00000017428 AllianceGenome:MGI:1916327
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S9; P44.5; 1700089D09Rik; 1810019E17Rik; 2610024G20Rik; 2810055C24Rik
    Summary
    Predicted to enable structural molecule activity. Predicted to be involved in proteasome assembly; stem cell differentiation; and ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Is expressed in central nervous system; heart; liver; neural retina; and skeletal muscle. Orthologous to human PSMD11 (proteasome 26S subunit, non-ATPase 11). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 25.8), liver E14 (RPKM 25.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Psmd11 in Genome Data Viewer
    Location:
    11 B5; 11 47.89 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (80319441..80364074)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (80428615..80473248)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5730455P16 gene Neighboring gene STARR-positive B cell enhancer ABC_E7026 Neighboring gene STARR-seq mESC enhancer starr_30146 Neighboring gene zinc finger protein 207 Neighboring gene STARR-seq mESC enhancer starr_30149 Neighboring gene cyclin dependent kinase 5, regulatory subunit 1 Neighboring gene predicted gene, 53690 Neighboring gene myosin ID

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Generation and identification of a conditional knockout allele for the PSMD11 gene in mice. Zhao L, et al. BMC Dev Biol, 2021 Feb 1. PMID 33517884, Free PMC Article
    2. GINIP, a Gαi-interacting protein, functions as a key modulator of peripheral GABAB receptor-mediated analgesia. Gaillard S, et al. Neuron, 2014 Oct 1. PMID 25242222, Free PMC Article
    3. An epigenetic circuit controls neurogenic programs during neocortex development. Wang A, et al. Development, 2021 Nov 15. PMID 35020876
    4. USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and Maintains Cerebellar Homeostasis. Kim J, et al. Mol Cell Biol, 2020 Oct 13. PMID 32839293, Free PMC Article
    5. Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis. Hamazaki J, et al. PLoS Genet, 2015 Jul. PMID 26222436, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Generation and identification of a conditional knockout allele for the PSMD11 gene in mice.
      Title: Generation and identification of a conditional knockout allele for the PSMD11 gene in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural molecule activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stem cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of proteasome accessory complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome accessory complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome regulatory particle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome regulatory particle, lid subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    26S proteasome non-ATPase regulatory subunit 11
    Names
    26S proteasome regulatory subunit RPN6
    26S proteasome regulatory subunit S9
    26S proteasome regulatory subunit p44.5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178616.3 → NP_848731.2  26S proteasome non-ATPase regulatory subunit 11

      See identical proteins and their annotated locations for NP_848731.2

      Status: VALIDATED

      Source sequence(s)
      AK136049, BC119138, BY092952
      Consensus CDS
      CCDS25133.1
      UniProtKB/Swiss-Prot
      Q8BG32
      UniProtKB/TrEMBL
      Q3THG2, Q3UWW9, Q5BKQ9
      Related
      ENSMUSP00000017572.8, ENSMUST00000017572.14
      Conserved Domains (1) summary
      COG5159
      Location:17 → 421
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      80319441..80364074
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249223.4 → XP_011247525.1  26S proteasome non-ATPase regulatory subunit 11 isoform X1

      UniProtKB/TrEMBL
      Q8K2N7
      Conserved Domains (1) summary
      COG5159
      Location:28 → 343
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BG32.3 GenPept UniProtKB/Swiss-Prot:Q8BG32

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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