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    RWDD2A RWD domain containing 2A [ Homo sapiens (human) ]

    Gene ID: 112611, updated on 10-Oct-2024

    Summary

    Official Symbol
    RWDD2Aprovided by HGNC
    Official Full Name
    RWD domain containing 2Aprovided by HGNC
    Primary source
    HGNC:HGNC:21385
    See related
    Ensembl:ENSG00000013392 AllianceGenome:HGNC:21385
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RWDD2; dJ747H23.2
    Expression
    Broad expression in prostate (RPKM 6.9), testis (RPKM 5.4) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See RWDD2A in Genome Data Viewer
    Location:
    6q14.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (83193357..83198935)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (84416598..84422177)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (83903076..83908654)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ubiquitin protein ligase E3D Neighboring gene leucine aminopeptidase 3 pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:83710771-83710962 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:83747652-83748851 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24781 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24783 Neighboring gene NANOG hESC enhancer GRCh37_chr6:83821047-83821571 Neighboring gene DOP1 leucine zipper like protein A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17356 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:83902947-83903446 Neighboring gene phosphoglucomutase 3 Neighboring gene MPRA-validated peak5928 silencer Neighboring gene malic enzyme 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:84004031-84004257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24784 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17358 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:84140986-84142185 Neighboring gene serine protease 35

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    RWD domain-containing protein 2A
    Names
    RWD domain containing 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001322335.2NP_001309264.1  RWD domain-containing protein 2A isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' region, and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AJ420581, AK302978, AW197622, BC104816, CN414510, DA032938, DC377982
      UniProtKB/TrEMBL
      B4DZK9
      Conserved Domains (2) summary
      pfam06544
      Location:85206
      DUF1115; Protein of unknown function (DUF1115)
      cl02687
      Location:159
      RWD; RWD domain
    2. NM_001322336.2NP_001309265.1  RWD domain-containing protein 2A isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an additional internal exon and thus differs in its 5' UTR and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a. Variants 3, 4 and 5 all encode isoform c.
      Source sequence(s)
      AJ420581, AW197622, BC104816, CD108545, CN414510, DA032938, DC377982
      UniProtKB/TrEMBL
      B4DZK9
      Conserved Domains (2) summary
      pfam06544
      Location:94215
      DUF1115; Protein of unknown function (DUF1115)
      cl02687
      Location:268
      RWD; RWD domain
    3. NM_001322337.2NP_001309266.1  RWD domain-containing protein 2A isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an additional internal exon and thus differs in its 5' UTR and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a. Variants 3, 4 and 5 all encode isoform c.
      Source sequence(s)
      AJ420581, AW197622, BC104816, BG676907, CN414510, DA032938, DC377982
      UniProtKB/TrEMBL
      B4DZK9
      Conserved Domains (2) summary
      pfam06544
      Location:94215
      DUF1115; Protein of unknown function (DUF1115)
      cl02687
      Location:268
      RWD; RWD domain
    4. NM_001322339.2NP_001309268.1  RWD domain-containing protein 2A isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 5' region and contains an additional internal exon, and it thus differs in its 5' UTR and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a. Variants 3, 4 and 5 all encode isoform c.
      Source sequence(s)
      AJ420581, AW197622, BC104816, CD108545, CN414510, DA032938, DC377982
      UniProtKB/TrEMBL
      B4DZK9
      Conserved Domains (2) summary
      pfam06544
      Location:94215
      DUF1115; Protein of unknown function (DUF1115)
      cl02687
      Location:268
      RWD; RWD domain
    5. NM_033411.5NP_219479.2  RWD domain-containing protein 2A isoform a

      See identical proteins and their annotated locations for NP_219479.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AJ420581, AK313083, AW197622, BC104816, CN414510, DA032938, DC377982
      Consensus CDS
      CCDS4998.1
      UniProtKB/Swiss-Prot
      B4DIQ3, E1P548, Q2M3R3, Q96FH1, Q9UIY3
      UniProtKB/TrEMBL
      B2R7R2
      Related
      ENSP00000358739.3, ENST00000369724.5
      Conserved Domains (2) summary
      smart00591
      Location:15134
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      pfam06544
      Location:160281
      DUF1115; Protein of unknown function (DUF1115)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      83193357..83198935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418135.1XP_047274091.1  RWD domain-containing protein 2A isoform X2

    2. XM_047418134.1XP_047274090.1  RWD domain-containing protein 2A isoform X1

      UniProtKB/Swiss-Prot
      B4DIQ3, E1P548, Q2M3R3, Q96FH1, Q9UIY3
    3. XM_017010222.3XP_016865711.1  RWD domain-containing protein 2A isoform X2

      UniProtKB/TrEMBL
      B4DZK9
      Conserved Domains (2) summary
      pfam06544
      Location:94215
      DUF1115; Protein of unknown function (DUF1115)
      cl02687
      Location:268
      RWD; RWD domain
    4. XM_017010223.2XP_016865712.1  RWD domain-containing protein 2A isoform X2

      UniProtKB/TrEMBL
      B4DZK9
      Conserved Domains (2) summary
      pfam06544
      Location:94215
      DUF1115; Protein of unknown function (DUF1115)
      cl02687
      Location:268
      RWD; RWD domain
    5. XM_047418136.1XP_047274092.1  RWD domain-containing protein 2A isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      84416598..84422177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354137.1XP_054210112.1  RWD domain-containing protein 2A isoform X2

    2. XM_054354138.1XP_054210113.1  RWD domain-containing protein 2A isoform X2

    3. XM_054354139.1XP_054210114.1  RWD domain-containing protein 2A isoform X2

    4. XM_054354135.1XP_054210110.1  RWD domain-containing protein 2A isoform X1

      UniProtKB/Swiss-Prot
      B4DIQ3, E1P548, Q2M3R3, Q96FH1, Q9UIY3
    5. XM_054354136.1XP_054210111.1  RWD domain-containing protein 2A isoform X2