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    Grb7 growth factor receptor bound protein 7 [ Mus musculus (house mouse) ]

    Gene ID: 14786, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Grb7provided by MGI
    Official Full Name
    growth factor receptor bound protein 7provided by MGI
    Primary source
    MGI:MGI:102683
    See related
    Ensembl:ENSMUSG00000019312 AllianceGenome:MGI:102683
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA4028
    Summary
    Predicted to enable identical protein binding activity; phosphatidylinositol binding activity; and protein kinase binding activity. Involved in negative regulation of translation and stress granule assembly. Located in cytoplasmic stress granule. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in esophagus adenocarcinoma. Orthologous to human GRB7 (growth factor receptor bound protein 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in kidney adult (RPKM 50.8), liver adult (RPKM 48.1) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Grb7 in Genome Data Viewer
    Location:
    11 D; 11 61.75 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98337660..98346199)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98446834..98455373)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98254740-98254849 Neighboring gene STARR-seq mESC enhancer starr_30667 Neighboring gene post-GPI attachment to proteins 3 Neighboring gene erb-b2 receptor tyrosine kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E5275 Neighboring gene migration and invasion enhancer 1 Neighboring gene STARR-seq mESC enhancer starr_30668 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98320467-98320833 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98320999-98321108 Neighboring gene STARR-positive B cell enhancer ABC_E11772 Neighboring gene IKAROS family zinc finger 3 Neighboring gene predicted gene, 25106 Neighboring gene STARR-positive B cell enhancer ABC_E7058 Neighboring gene VISTA enhancer mm503 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98388491-98388674 Neighboring gene STARR-positive B cell enhancer ABC_E8880 Neighboring gene STARR-positive B cell enhancer ABC_E8450 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98412942-98413125 Neighboring gene zona pellucida binding protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Grb7 Ablation in Mice Improved Glycemic Control, Enhanced Insulin Signaling, and Increased Abdominal fat Mass in Females. Vermehren-Schmaedick A, et al. Endocrinology, 2024 Mar 29. PMID 38578949, Free PMC Article
    2. Grb7 knockout mice develop normally but litters born to knockout females fail to thrive. Lofgren KA, et al. Dev Dyn, 2024 Jul. PMID 38140940
    3. The adaptor Grb7 links netrin-1 signaling to regulation of mRNA translation. Tsai NP, et al. EMBO J, 2007 Mar 21. PMID 17318180, Free PMC Article
    4. Expression of Grb7 growth factor receptor signaling protein in kidney development and in adult kidney. Leavey SF, et al. Am J Physiol, 1998 Nov. PMID 9815134
    5. EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells. Chu PY, et al. J Biol Chem, 2010 Sep 17. PMID 20622016, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Grb7 Ablation in Mice Improved Glycemic Control, Enhanced Insulin Signaling, and Increased Abdominal fat Mass in Females.
      Title: Grb7 Ablation in Mice Improved Glycemic Control, Enhanced Insulin Signaling, and Increased Abdominal fat Mass in Females.
    2. GRB7 gene expression in uterus during embryo implantation is regulated by Mmu-miR-193.
      Title: Mmu-miR-193 is involved in embryo implantation in mouse uterus by regulating GRB7 gene expression.
    3. Findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy.
      Title: EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells.
    4. Grb7 is identified as an integral component of stress granules.
      Title: Regulation of stress granule dynamics by Grb7 and FAK signalling pathway.
    5. The adaptor Grb7 links netrin-1 signaling to regulation of mRNA translation of kappa opioid receptor.
      Title: The adaptor Grb7 links netrin-1 signaling to regulation of mRNA translation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4028, MGC78181

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in negative regulation of insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in stress granule assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    growth factor receptor-bound protein 7
    Names
    GRB7 adapter protein
    Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7)
    epidermal growth factor receptor GRB-7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010346.2 → NP_034476.1  growth factor receptor-bound protein 7

      See identical proteins and their annotated locations for NP_034476.1

      Status: VALIDATED

      Source sequence(s)
      AK168438, AW494536, CA496861
      Consensus CDS
      CCDS25351.1
      UniProtKB/Swiss-Prot
      Q03160, Q3TH55
      Related
      ENSMUSP00000019456.5, ENSMUST00000019456.5
      Conserved Domains (4) summary
      cd10413
      Location:428 → 535
      SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
      cd01259
      Location:224 → 350
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16140
      Location:102 → 186
      RA_GRB7; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 7
      pfam08947
      Location:369 → 413
      BPS; BPS (Between PH and SH2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      98337660..98346199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532233.1 → XP_006532296.1  growth factor receptor-bound protein 7 isoform X1

      See identical proteins and their annotated locations for XP_006532296.1

      UniProtKB/Swiss-Prot
      Q03160, Q3TH55
      Conserved Domains (4) summary
      cd10413
      Location:428 → 535
      SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
      cd01259
      Location:224 → 350
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16140
      Location:102 → 186
      RA_GRB7; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 7
      pfam08947
      Location:369 → 413
      BPS; BPS (Between PH and SH2)

    2. XM_030245575.1 → XP_030101435.1  growth factor receptor-bound protein 7 isoform X1

      UniProtKB/Swiss-Prot
      Q03160, Q3TH55
      Conserved Domains (4) summary
      cd10413
      Location:428 → 535
      SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
      cd01259
      Location:224 → 350
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16140
      Location:102 → 186
      RA_GRB7; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 7
      pfam08947
      Location:369 → 413
      BPS; BPS (Between PH and SH2)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03160.1 GenPept UniProtKB/Swiss-Prot:Q03160

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