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    Adgrl4 adhesion G protein-coupled receptor L4 [ Mus musculus (house mouse) ]

    Gene ID: 170757, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Adgrl4provided by MGI
    Official Full Name
    adhesion G protein-coupled receptor L4provided by MGI
    Primary source
    MGI:MGI:2655562
    See related
    Ensembl:ENSMUSG00000039167 AllianceGenome:MGI:2655562
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Etl; ETL1; Eltd1; 1110033N21Rik
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and protein-containing complex assembly. Predicted to be located in cytoplasmic vesicle. Predicted to be active in plasma membrane. Is expressed in cardiovascular system; lung; metanephros; and skeletal muscle. Orthologous to human ADGRL4 (adhesion G protein-coupled receptor L4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lung adult (RPKM 19.1), subcutaneous fat pad adult (RPKM 9.6) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adgrl4 in Genome Data Viewer
    Location:
    3 H3; 3 76.76 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (151143519..151250718)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (151437882..151545081)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene microRNA 3963 Neighboring gene RIKEN cDNA 4930555A03 gene Neighboring gene predicted gene, 24458 Neighboring gene STARR-seq mESC enhancer starr_09275 Neighboring gene interferon-induced protein 44

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ELTD1 deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma. Huang H, et al. Neuro Oncol, 2022 Mar 12. PMID 34347079, Free PMC Article
    2. Augmented cardiac hypertrophy in response to pressure overload in mice lacking ELTD1. Xiao J, et al. PLoS One, 2012. PMID 22606234, Free PMC Article
    3. ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily. Nechiporuk T, et al. J Biol Chem, 2001 Feb 9. PMID 11050079
    4. The EGF-TM7 family: a postgenomic view. Kwakkenbos MJ, et al. Immunogenetics, 2004 Jan. PMID 14647991
    5. From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs. Terskikh AV, et al. Proc Natl Acad Sci U S A, 2001 Jul 3. PMID 11438738, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ELTD1 deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma.
      Title: ELTD1 deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma.
    2. loss of GPR116 and ELTD1 expressed by other cells accounts for the observed cardiovascular and renal defects.
      Title: Developmental vascular remodeling defects and postnatal kidney failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4).
    3. ELTD1 deficiency exacerbates cardiac hypertrophy and cardiac function induced by aortic banding-induced pressure overload by promoting both cardiomyocyte hypertrophy and cardiac fibrosis.
      Title: Augmented cardiac hypertrophy in response to pressure overload in mice lacking ELTD1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (7)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of synapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor L4
    Names
    EGF, latrophilin seven transmembrane domain containing 1
    EGF, latrophilin seven transmembrane domain-containing protein 1
    EGF-TM7 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133222.3 → NP_573485.2  adhesion G protein-coupled receptor L4 precursor

      See identical proteins and their annotated locations for NP_573485.2

      Status: VALIDATED

      Source sequence(s)
      AC127233
      Consensus CDS
      CCDS17910.1
      UniProtKB/Swiss-Prot
      E9QLT4, Q91W44, Q923X1
      Related
      ENSMUSP00000041939.8, ENSMUST00000046977.12
      Conserved Domains (4) summary
      smart00179
      Location:58 → 91
      EGF_CA; Calcium-binding EGF-like domain
      pfam01825
      Location:417 → 461
      GPS; GPCR proteolysis site, GPS, motif
      pfam16489
      Location:190 → 370
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl21561
      Location:473 → 709
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      151143519..151250718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q923X1.3 GenPept UniProtKB/Swiss-Prot:Q923X1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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