Diras2 DIRAS family, GTP-binding RAS-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Diras2provided by MGI
Official Full Name: DIRAS family, GTP-binding RAS-like 2provided by MGI
Primary source: MGI:MGI:1915453
See related: Ensembl:ENSMUSG00000047842 AllianceGenome:MGI:1915453
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2900052J15Rik
Summary: Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in signal transduction. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; cerebellum external granule cell layer; intestine; liver; and retina layer. Orthologous to human DIRAS2 (DIRAS family GTPase 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in cerebellum adult (RPKM 71.8), cortex adult (RPKM 48.9) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A5; 13 27.3 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (52658411..52685390, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (52504375..52531354, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of the ADHD Candidate Gene Diras2 in Murine Hippocampal Primary Cells.
Title: Knockdown of the ADHD Candidate Gene Diras2 in Murine Hippocampal Primary Cells.
Our findings support the idea of DIRAS2 as a candidate gene for attention-deficit/hyperactivity disorder
Title: Expression of the ADHD candidate gene Diras2 in the brain.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI414999 (e-PCR)
- UniSTS:160302

RH129418 (e-PCR)
- UniSTS:212725

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: GTP-binding protein Di-Ras2

Names: distinct subgroup of the Ras family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.