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    Eif3k eukaryotic translation initiation factor 3, subunit K [ Mus musculus (house mouse) ]

    Gene ID: 73830, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Eif3kprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 3, subunit Kprovided by MGI
    Primary source
    MGI:MGI:1921080
    See related
    Ensembl:ENSMUSG00000053565 AllianceGenome:MGI:1921080
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eif3s12; 1200009C21Rik
    Summary
    Contributes to translation initiation factor activity. Involved in translational initiation. Part of eukaryotic translation initiation factor 3 complex. Is expressed in embryo. Orthologous to human EIF3K (eukaryotic translation initiation factor 3 subunit K). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 97.7), placenta adult (RPKM 93.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eif3k in Genome Data Viewer
    Location:
    7 B1; 7 16.94 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28670797..28681322, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28971372..28981890, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene actinin alpha 4 Neighboring gene STARR-seq mESC enhancer starr_18446 Neighboring gene predicted gene, 38978 Neighboring gene predicted gene, 51446 Neighboring gene STARR-seq mESC enhancer starr_18451 Neighboring gene STARR-positive B cell enhancer ABC_E698 Neighboring gene STARR-positive B cell enhancer ABC_E1729 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 1 Neighboring gene ryanodine receptor 1, skeletal muscle Neighboring gene predicted gene, 38979

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of human eIF3k, the first structure of eIF3 subunits. Wei Z, et al. J Biol Chem, 2004 Aug 13. PMID 15180986
    2. eIF3k regulates apoptosis in epithelial cells by releasing caspase 3 from keratin-containing inclusions. Lin YM, et al. J Cell Sci, 2008 Jul 15. PMID 18577580
    3. Controlling tissue patterning by translational regulation of signaling transcripts through the core translation factor eIF3c. Fujii K, et al. Dev Cell, 2021 Nov 8. PMID 34752747, Free PMC Article
    4. Reconstitution reveals the functional core of mammalian eIF3. Masutani M, et al. EMBO J, 2007 Jul 25. PMID 17581632, Free PMC Article
    5. Systematic identification of factors for provirus silencing in embryonic stem cells. Yang BX, et al. Cell, 2015 Sep 24. PMID 26365490, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in formation of cytoplasmic translation initiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic 43S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 3 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3 subunit K
    Names
    eIF-3 p25
    eukaryotic translation initiation factor 3, subunit 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285942.2 → NP_001272871.1  eukaryotic translation initiation factor 3 subunit K isoform 2

      See identical proteins and their annotated locations for NP_001272871.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC166357
      Consensus CDS
      CCDS85254.1
      UniProtKB/Swiss-Prot
      Q9DBZ5
      Related
      ENSMUSP00000146940.2, ENSMUST00000207683.2
      Conserved Domains (1) summary
      pfam10075
      Location:28 → 156
      CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

    2. NM_001285943.2 → NP_001272872.1  eukaryotic translation initiation factor 3 subunit K isoform 3

      See identical proteins and their annotated locations for NP_001272872.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) lacks an alternate internal segment and has a longer and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC166357
      Consensus CDS
      CCDS85255.1
      UniProtKB/TrEMBL
      Q3TY56
      Related
      ENSMUSP00000147214.2, ENSMUST00000208616.2
      Conserved Domains (1) summary
      pfam10075
      Location:28 → 156
      CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

    3. NM_028659.4 → NP_082935.1  eukaryotic translation initiation factor 3 subunit K isoform 1

      See identical proteins and their annotated locations for NP_082935.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC166357
      Consensus CDS
      CCDS21062.1
      UniProtKB/Swiss-Prot
      Q58EU9, Q8K3A1, Q9DBZ5
      Related
      ENSMUSP00000066038.6, ENSMUST00000066070.7
      Conserved Domains (1) summary
      pfam10075
      Location:61 → 189
      CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      28670797..28681322 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540392.5 → XP_006540455.1  eukaryotic translation initiation factor 3 subunit K isoform X1

      Conserved Domains (1) summary
      cl24019
      Location:1 → 102
      CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBZ5.1 GenPept UniProtKB/Swiss-Prot:Q9DBZ5

    Gene LinkOut

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