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    Lemd1 LEM domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 213409, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Lemd1provided by MGI
    Official Full Name
    LEM domain containing 1provided by MGI
    Primary source
    MGI:MGI:1922403
    See related
    Ensembl:ENSMUSG00000079330 AllianceGenome:MGI:1922403
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LEMP-1; 4930540I23Rik; 6430514M23Rik
    Summary
    Orthologous to human LEMD1 (LEM domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 12.8), CNS E14 (RPKM 1.7) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lemd1 in Genome Data Viewer
    Location:
    1 E4; 1 57.24 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (132118361..132185120)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (132190629..132257382)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30153 Neighboring gene STARR-positive B cell enhancer mm9_chr1:134052383-134052684 Neighboring gene predicted gene, 30242 Neighboring gene predicted gene, 29695 Neighboring gene STARR-seq mESC enhancer starr_02235 Neighboring gene microRNA 135b Neighboring gene STARR-seq mESC enhancer starr_02242 Neighboring gene predicted gene 29630 Neighboring gene STARR-seq mESC enhancer starr_02247 Neighboring gene predicted gene, 38446 Neighboring gene predicted pseudogene 7241

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
    2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    LEM domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033250.4 → NP_001028422.2  LEM domain-containing protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001028422.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks two alternate coding exons compared to variant 1, that results in a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK144269, BC115462, CO040031
      Consensus CDS
      CCDS35705.1
      UniProtKB/Swiss-Prot
      Q14C37
      Related
      ENSMUSP00000107976.3, ENSMUST00000112357.9
      Conserved Domains (1) summary
      cd12940
      Location:3 → 44
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins

    2. NM_001311102.1 → NP_001298031.1  LEM domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001298031.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC124108, AC160545, AK016010, AK144269, CO040031
      Consensus CDS
      CCDS78679.1
      UniProtKB/TrEMBL
      A0A087WQH1
      Related
      ENSMUSP00000140193.2, ENSMUST00000191418.2
      Conserved Domains (1) summary
      cd12940
      Location:3 → 44
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins

    3. NM_001311103.1 → NP_001298032.1  LEM domain-containing protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, which results in translation initiation from a downstream AUG. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC124108, AK016010, BY715589, CO040031

    4. NM_001311104.1 → NP_001298033.1  LEM domain-containing protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001298033.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate coding exon compared to variant 1, that results in a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK144269, CO040031
      Consensus CDS
      CCDS83590.1
      UniProtKB/TrEMBL
      A0A087WR92
      Related
      ENSMUSP00000140524.2, ENSMUST00000188169.7
      Conserved Domains (1) summary
      cd12940
      Location:3 → 44
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins

    RNA

    1. NR_132336.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon and uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC124108, AK016010, CO040031
      Related
      ENSMUST00000185436.7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      132118361..132185120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163412.1 → XP_036019305.1  LEM domain-containing protein 1 isoform X3

    2. XM_006529349.3 → XP_006529412.1  LEM domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006529412.1

      UniProtKB/TrEMBL
      A0A087WQH1
      Conserved Domains (1) summary
      cd12940
      Location:3 → 44
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins

    3. XM_006529347.3 → XP_006529410.1  LEM domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006529410.1

      UniProtKB/TrEMBL
      A0A087WQH1
      Conserved Domains (1) summary
      cd12940
      Location:3 → 44
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins

    4. XM_006529348.4 → XP_006529411.1  LEM domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006529411.1

      UniProtKB/TrEMBL
      A0A087WQH1
      Conserved Domains (1) summary
      cd12940
      Location:3 → 44
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins

    5. XM_011247970.2 → XP_011246272.1  LEM domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011246272.1

      UniProtKB/TrEMBL
      A0A087WQH1
      Conserved Domains (1) summary
      cd12940
      Location:3 → 44
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins

    6. XM_006529352.4 → XP_006529415.1  LEM domain-containing protein 1 isoform X4

      See identical proteins and their annotated locations for XP_006529415.1

      UniProtKB/TrEMBL
      A0A087WR92
      Conserved Domains (1) summary
      cd12940
      Location:3 → 44
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins

    7. XM_036163414.1 → XP_036019307.1  LEM domain-containing protein 1 isoform X5

      Conserved Domains (1) summary
      pfam03020
      Location:3 → 42
      LEM; LEM domain

    8. XM_006529351.4 → XP_006529414.1  LEM domain-containing protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006529414.1

      UniProtKB/Swiss-Prot
      Q14C37
      Conserved Domains (1) summary
      cd12940
      Location:3 → 44
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins

    9. XM_006529350.5 → XP_006529413.1  LEM domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006529413.1

      UniProtKB/TrEMBL
      A0A087WQH1
      Conserved Domains (1) summary
      cd12940
      Location:3 → 44
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14C37.1 GenPept UniProtKB/Swiss-Prot:Q14C37

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