Dpysl2 dihydropyrimidinase-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dpysl2provided by MGI
Official Full Name: dihydropyrimidinase-like 2provided by MGI
Primary source: MGI:MGI:1349763
See related: Ensembl:ENSMUSG00000022048 AllianceGenome:MGI:1349763
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DRP2; Crmp2; Ulip2; TOAD-64; Musunc33
Summary: Enables protein kinase binding activity. Involved in cytoskeleton organization. Acts upstream of or within regulation of neuron projection development. Located in axon; dendrite; and neuronal cell body. Is active in Schaffer collateral - CA1 synapse and postsynaptic density. Is expressed in several structures, including alimentary system; cranium; nervous system; respiratory system; and sensory organ. Orthologous to human DPYSL2 (dihydropyrimidinase like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E18 (RPKM 51.3), whole brain E14.5 (RPKM 47.9) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D1; 14 34.6 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (67040313..67148490, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (66802864..66911041, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Synapse-Enriched m[6]A-Modified Malat1 Interacts with the Novel m[6]A Reader, DPYSL2, and Is Required for Fear-Extinction Memory.
Title: Synapse-Enriched m(6)A-Modified Malat1 Interacts with the Novel m(6)A Reader, DPYSL2, and Is Required for Fear-Extinction Memory.
CRMP2 conditional knockout changes axonal function and ultrastructure of axons in mice corpus callosum.
Title: CRMP2 conditional knockout changes axonal function and ultrastructure of axons in mice corpus callosum.
CRMP2 Participates in Regulating Mitochondrial Morphology and Motility in Alzheimer's Disease.
Title: CRMP2 Participates in Regulating Mitochondrial Morphology and Motility in Alzheimer's Disease.
Genetic inhibition of collapsin response mediator protein-2 phosphorylation ameliorates retinal ganglion cell death in normal-tension glaucoma models.
Title: Genetic inhibition of collapsin response mediator protein-2 phosphorylation ameliorates retinal ganglion cell death in normal-tension glaucoma models.
Requirement of CRMP2 Phosphorylation in Neuronal Migration of Developing Mouse Cerebral Cortex and Hippocampus and Redundant Roles of CRMP1 and CRMP4.
Title: Requirement of CRMP2 Phosphorylation in Neuronal Migration of Developing Mouse Cerebral Cortex and Hippocampus and Redundant Roles of CRMP1 and CRMP4.
Betaine ameliorates schizophrenic traits by functionally compensating for KIF3-based CRMP2 transport.
Title: Betaine ameliorates schizophrenic traits by functionally compensating for KIF3-based CRMP2 transport.
Involvement of CRMP2 in Regulation of Mitochondrial Morphology and Motility in Huntington's Disease.
Title: Involvement of CRMP2 in Regulation of Mitochondrial Morphology and Motility in Huntington's Disease.
CRMP2 Is Involved in Regulation of Mitochondrial Morphology and Motility in Neurons.
Title: CRMP2 Is Involved in Regulation of Mitochondrial Morphology and Motility in Neurons.
Phosphorylation of CRMP2 is required for migration and positioning of Purkinje cells: Redundant roles of CRMP1 and CRMP4.
Title: Phosphorylation of CRMP2 is required for migration and positioning of Purkinje cells: Redundant roles of CRMP1 and CRMP4.
PKCgamma-Mediated Phosphorylation of CRMP2 Regulates Dendritic Outgrowth in Cerebellar Purkinje Cells.
Title: PKCγ-Mediated Phosphorylation of CRMP2 Regulates Dendritic Outgrowth in Cerebellar Purkinje Cells.

Submit: New GeneRIF Correction See all GeneRIFs (58)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dpysl2 (e-PCR), detects polymorphism
- UniSTS:546744

AI851130 (e-PCR)
- UniSTS:180681

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables dihydropyrimidinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in endocytosis	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glutamate secretion	ISO Inferred from Sequence Orthology more info
NOT involved_in pyrimidine nucleobase catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuron projection development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synaptic vesicle transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
colocalizes_with membrane	ISO Inferred from Sequence Orthology more info
colocalizes_with membrane	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with microtubule	ISO Inferred from Sequence Orthology more info
colocalizes_with microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
located_in myelin sheath	HDA more info	PubMed
located_in myelin sheath	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IEP Inferred from Expression Pattern more info	PubMed
is_active_in postsynaptic density	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dihydropyrimidinase-related protein 2

Names: DRP-2; ULIP-2; collapsin response mediator protein 2; unc-33-like phosphoprotein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001378767.1 → NP_001365696.1 dihydropyrimidinase-related protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC154693, AC165148

UniProtKB/TrEMBL

A0AAQ4VMY7

Related

ENSMUSP00000160026.1, ENSMUST00000249932.1

Conserved Domains (1) summary

cd01314
Location:118 → 567

D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
NM_009955.3 → NP_034085.2 dihydropyrimidinase-related protein 2 isoform 2

See identical proteins and their annotated locations for NP_034085.2

Status: VALIDATED

Source sequence(s)

AC154693, BC062955

Consensus CDS

CCDS27224.1

UniProtKB/Swiss-Prot

O08553, Q6P5D0

Related

ENSMUSP00000022629.9, ENSMUST00000022629.9

Conserved Domains (1) summary

cd01314
Location:17 → 466

D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

67040313..67148490 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158432.1 → XP_036014325.1 dihydropyrimidinase-related protein 2 isoform X1

Conserved Domains (1) summary

cd01314
Location:5 → 454

D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...