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    Rnase4 ribonuclease, RNase A family 4 [ Mus musculus (house mouse) ]

    Gene ID: 58809, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rnase4provided by MGI
    Official Full Name
    ribonuclease, RNase A family 4provided by MGI
    Primary source
    MGI:MGI:1926217
    See related
    Ensembl:ENSMUSG00000021876 AllianceGenome:MGI:1926217
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rab1; C730049F20Rik
    Summary
    This gene encodes a member of the pancreatic ribonuclease A superfamily. The encoded enzyme is sereted and has unique uridine specificity. This gene resides in a cluster of highly related genes. It shares dual promoters and 5' exons with the angiogenin, ribonuclease, RNase A family, 5 gene. Each gene splices to a unique downstream exon that contains its complete coding region. Two alternatively spliced variants, with different 5' exons but the same coding exon, have been identified. [provided by RefSeq, Jun 2009]
    Expression
    Biased expression in liver adult (RPKM 541.8), lung adult (RPKM 184.6) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnase4 in Genome Data Viewer
    Location:
    14 C1; 14 26.37 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (51328534..51343608)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (51091077..51106151)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5432 Neighboring gene STARR-positive B cell enhancer ABC_E3111 Neighboring gene nuclear encoded tRNA tyrosine 10 (anticodon GTA) Neighboring gene nuclear encoded tRNA proline 5 (anticodon TGG) Neighboring gene angiogenin, ribonuclease, RNase A family, 5 Neighboring gene STARR-positive B cell enhancer ABC_E4108 Neighboring gene epididymal protein 3B Neighboring gene ribonuclease, RNase A family, 6 Neighboring gene STARR-positive B cell enhancer ABC_E9895

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ribonuclease 4, an evolutionarily highly conserved member of the superfamily. Hofsteenge J, et al. Cell Mol Life Sci, 1998 Aug. PMID 9760989, Free PMC Article
    2. Ribonuclease 4 functions as an intestinal antimicrobial protein to maintain gut microbiota and metabolite homeostasis. Sun J, et al. Nat Commun, 2024 Jul 10. PMID 38987259, Free PMC Article
    3. Isolation of bona fide differentially expressed genes in the 18-hour sepsis liver by suppression subtractive hybridization. Hsieh YC, et al. Shock, 2004 Jun. PMID 15167684
    4. The mouse RNase 4 and RNase 5/ang 1 locus utilizes dual promoters for tissue-specific expression. Dyer KD, et al. Nucleic Acids Res, 2005. PMID 15722482, Free PMC Article
    5. The RNase a superfamily: generation of diversity and innate host defense. Dyer KD, et al. Mol Divers, 2006 Nov. PMID 16969722

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA nuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA nuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antibacterial humoral response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in antibacterial humoral response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antibacterial humoral response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within cellular response to starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ribonuclease 4
    Names
    RNase 4
    ribonuclease A b1
    NP_067447.2
    NP_957691.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021472.4 → NP_067447.2  ribonuclease 4 precursor

      See identical proteins and their annotated locations for NP_067447.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC163664, BC061105, CD742377
      Consensus CDS
      CCDS27035.1
      UniProtKB/Swiss-Prot
      Q9JJH1
      UniProtKB/TrEMBL
      Q5UCA9, Q8C7E4
      Related
      ENSMUSP00000022428.6, ENSMUST00000022428.13
      Conserved Domains (1) summary
      smart00092
      Location:30 → 148
      RNAse_Pc; Pancreatic ribonuclease

    2. NM_201239.3 → NP_957691.1  ribonuclease 4 precursor

      See identical proteins and their annotated locations for NP_957691.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC163664, AK050451, CD742377
      Consensus CDS
      CCDS27035.1
      UniProtKB/Swiss-Prot
      Q9JJH1
      UniProtKB/TrEMBL
      Q5UCA9, Q8C7E4
      Related
      ENSMUSP00000127274.2, ENSMUST00000169895.3
      Conserved Domains (1) summary
      smart00092
      Location:30 → 148
      RNAse_Pc; Pancreatic ribonuclease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      51328534..51343608
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJH1.1 GenPept UniProtKB/Swiss-Prot:Q9JJH1

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