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    Or1e1c olfactory receptor family 1 subfamily E member 1C [ Mus musculus (house mouse) ]

    Gene ID: 258924, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Or1e1cprovided by MGI
    Official Full Name
    olfactory receptor family 1 subfamily E member 1Cprovided by MGI
    Primary source
    MGI:MGI:3030210
    See related
    Ensembl:ENSMUSG00000063881 AllianceGenome:MGI:3030210
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Olfr376; MOR135-12
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Or1e1c in Genome Data Viewer
    Location:
    11 B4; 11 45.32 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (73262072..73266530)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (73371246..73375704)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene aspartoacylase Neighboring gene spermatogenesis associated 22 Neighboring gene olfactory receptor family 1 subfamily E member 1 Neighboring gene olfactory receptor family 1 subfamily E member 18, pseudogene 1 Neighboring gene lymphocyte antigen 6 complex, locus E pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Olfactory receptors and signalling elements in the Grueneberg ganglion. Fleischer J, et al. J Neurochem, 2006 Jul. PMID 16805845
    2. The olfactory receptor gene superfamily of the mouse. Zhang X, et al. Nat Neurosci, 2002 Feb. PMID 11802173
    3. Different evolutionary processes shaped the mouse and human olfactory receptor gene families. Young JM, et al. Hum Mol Genet, 2002 Mar 1. PMID 11875048
    4. Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels. Young JM, et al. Genome Biol, 2003. PMID 14611657, Free PMC Article
    5. A unified nomenclature for vertebrate olfactory receptors. Olender T, et al. BMC Evol Biol, 2020 Apr 15. PMID 32295537, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables olfactory receptor activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of smell ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    olfactory receptor 376
    Names
    GA_x6K02T2P1NL-3535075-3536028
    olfactory receptor MOR135-12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172686.1 → NP_001166157.1  olfactory receptor 376 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer isoform (1). The coding region contains an intron, which is atypical for olfactory receptor genes, so translation initiation may actually occur at a downstream in-frame start codon.
      Source sequence(s)
      AL645739
      Consensus CDS
      CCDS48844.1
      UniProtKB/TrEMBL
      E9Q4M1, Q8VGI3
      Related
      ENSMUSP00000077977.3, ENSMUST00000078952.9
      Conserved Domains (2) summary
      pfam00001
      Location:60 → 296
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:37 → 314
      7tm_4; Olfactory receptor

    2. NM_146922.2 → NP_667133.1  olfactory receptor 376 isoform 2

      See identical proteins and their annotated locations for NP_667133.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AL645739
      Consensus CDS
      CCDS25007.1
      UniProtKB/TrEMBL
      Q8VGI2, Q8VGI3
      Related
      ENSMUSP00000126073.2, ENSMUST00000170592.4
      Conserved Domains (2) summary
      pfam00001
      Location:57 → 293
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:34 → 311
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      73262072..73266530
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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