Irf2bp1 interferon regulatory factor 2 binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Irf2bp1provided by MGI
Official Full Name: interferon regulatory factor 2 binding protein 1provided by MGI
Primary source: MGI:MGI:2442159
See related: Ensembl:ENSMUSG00000044030 AllianceGenome:MGI:2442159
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C530033F24; 6330414O09Rik
Summary: Predicted to enable transcription corepressor activity and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and protein polyubiquitination. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in eye. Orthologous to human IRF2BP1 (interferon regulatory factor 2 binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 9.46 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (18737983..18740688)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (19004058..19006763)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables transcription factor binding	ISO Inferred from Sequence Orthology more info	PubMed
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: interferon regulatory factor 2-binding protein 1

Names: IRF-2-binding protein 1; IRF-2BP1; probable E3 ubiquitin-protein ligase IRF2BP1; probable RING-type E3 ubiquitin transferase IRF2BP1

NP_848872.2

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178757.4 → NP_848872.2 interferon regulatory factor 2-binding protein 1

See identical proteins and their annotated locations for NP_848872.2

Status: VALIDATED

Source sequence(s)

AC170864

Consensus CDS

CCDS20885.1

UniProtKB/Swiss-Prot

Q8BJC9, Q8C0B1, Q8CI76, Q8R3Y8

Related

ENSMUSP00000061234.4, ENSMUST00000053713.5

Conserved Domains (3) summary

pfam00097
Location:503 → 547

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam10631
Location:348 → 414

DUF2477; Protein of unknown function (DUF2477)

pfam11261
Location:8 → 59

IRF-2BP1_2; Interferon regulatory factor 2-binding protein zinc finger