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    MAILR macrophage interferon regulatory lncRNA [ Homo sapiens (human) ]

    Gene ID: 100506753, updated on 17-Sep-2024

    Summary

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    Official Symbol
    MAILRprovided by HGNC
    Official Full Name
    macrophage interferon regulatory lncRNAprovided by HGNC
    Primary source
    HGNC:HGNC:51558
    See related
    AllianceGenome:HGNC:51558
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MAIL1; H22954; AZIN1-AS1
    Expression
    Broad expression in brain (RPKM 1.8), testis (RPKM 1.7) and 24 other tissues See more
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    Genomic context

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    See MAILR in Genome Data Viewer
    Location:
    8q22.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (102864271..102977876)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (103992512..104105839)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (103876499..103990104)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19445 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:103820470-103821096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19446 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27778 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27779 Neighboring gene Sharpr-MPRA regulatory region 950 Neighboring gene growth arrest associated lncRNA 1 Neighboring gene antizyme inhibitor 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:103874535-103875268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19447 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:103876737-103877469 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:103884433-103884932 Neighboring gene uncharacterized LOC124902000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27781 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19449 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:103907133-103907680 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:103908196-103908325 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27782 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:103917298-103917873 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:103918088-103919287 Neighboring gene Sharpr-MPRA regulatory region 791 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27783 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27784 Neighboring gene ribosomal protein L5 pseudogene 24 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19451 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19453 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27785 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27786 Neighboring gene nucleophosmin 1 pseudogene 52 Neighboring gene ATPase H+ transporting V1 subunit C1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. H22954, a novel long non-coding RNA down-regulated in AML, inhibits cancer growth in a BCL-2-dependent mechanism. Qi X, et al. Cancer Lett, 2019 Jul 10. PMID 30959078
    2. Noncoding RNA MaIL1 is an integral component of the TLR4-TRIF pathway. Aznaourova M, et al. Proc Natl Acad Sci U S A, 2020 Apr 21. PMID 32241891, Free PMC Article
    3. Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants. Wistow G, et al. Mol Vis, 2002 Jun 15. PMID 12107413

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Other Names

    • AZIN1 antisense RNA 1
    • Macrophage Interferon-regulatory LncRNA 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_126338.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AA608797, CD675847, HY037378, HY048574

    2. NR_126339.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon, resulting in a shorter transcript than variant 1.
      Source sequence(s)
      AA608797, BF939259, HY037378, HY048574

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      102864271..102977876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      103992512..104105839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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