ZNF165 zinc finger protein 165 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF165provided by HGNC
Official Full Name: zinc finger protein 165provided by HGNC
Primary source: HGNC:HGNC:12953
See related: Ensembl:ENSG00000197279 MIM:600834; AllianceGenome:HGNC:12953
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CT53; LD65; ZSCAN7
Summary: This gene encodes a member of the Kruppel family of zinc finger proteins. Members of this DNA-binding protein family act as transcriptional regulators. This gene is located within a cluster of zinc finger family members. The encoded protein may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]
Expression: Broad expression in testis (RPKM 10.2), placenta (RPKM 2.3) and 15 other tissues See more
Orthologs: all
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Genomic context

Location:: 6p22.1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (28080282..28089563)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (27950300..27959582)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (28048060..28057341)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZNF165 Is Involved in the Regulation of Immune Microenvironment and Promoting the Proliferation and Migration of Hepatocellular Carcinoma by AhR/CYP1A1.
Title: ZNF165 Is Involved in the Regulation of Immune Microenvironment and Promoting the Proliferation and Migration of Hepatocellular Carcinoma by AhR/CYP1A1.
The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFbeta signaling in triple-negative breast cancer.
Title: The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer.
ZNF165 drives the unrestrained activation of transforming growth factor beta (TGFbeta) signalling by directly inactivating the expression of negative feedback pathway regulators, SMURF2, SMAD7 and PMEPA1.
Title: Comprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancer.
ZNF165 mRNA/protein expression was observed in TCC of human urinary bladder and might be used as a novel diagnostic biomarker and as well a vaccine target in development of urinary bladder cancer specific immunotherapy.
Title: Frequent expression of zinc-finger protein ZNF165 in human urinary bladder transitional cell carcinoma.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein 165

Names: cancer/testis antigen 53; zinc finger and SCAN domain-containing protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001376491.1 → NP_001363420.1 zinc finger protein 165 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).

Source sequence(s)

AL121944

Consensus CDS

CCDS4643.1

UniProtKB/Swiss-Prot

P49910

UniProtKB/TrEMBL

Q53Z40

Related

ENSP00000507525.1, ENST00000683778.1

Conserved Domains (4) summary

smart00431
Location:45 → 157

SCAN; leucine rich region

COG5048
Location:426 → 479

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:402 → 422

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:344 → 366

zf-C2H2; Zinc finger, C2H2 type
NM_001376492.1 → NP_001363421.1 zinc finger protein 165 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).

Source sequence(s)

AL121944

Consensus CDS

CCDS4643.1

UniProtKB/Swiss-Prot

P49910

UniProtKB/TrEMBL

Q53Z40

Conserved Domains (4) summary

smart00431
Location:45 → 157

SCAN; leucine rich region

COG5048
Location:426 → 479

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:402 → 422

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:344 → 366

zf-C2H2; Zinc finger, C2H2 type
NM_001376493.1 → NP_001363422.1 zinc finger protein 165 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).

Source sequence(s)

AL121944

Consensus CDS

CCDS4643.1

UniProtKB/Swiss-Prot

P49910

UniProtKB/TrEMBL

Q53Z40

Conserved Domains (4) summary

smart00431
Location:45 → 157

SCAN; leucine rich region

COG5048
Location:426 → 479

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:402 → 422

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:344 → 366

zf-C2H2; Zinc finger, C2H2 type
NM_001376494.1 → NP_001363423.1 zinc finger protein 165 isoform b

Status: REVIEWED

Source sequence(s)

AL121944

Conserved Domains (3) summary

COG5048
Location:234 → 287

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:210 → 230

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:152 → 174

zf-C2H2; Zinc finger, C2H2 type
NM_003447.4 → NP_003438.1 zinc finger protein 165 isoform a

See identical proteins and their annotated locations for NP_003438.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1-4 all encode the same isoform (a).

Source sequence(s)

AL121944, AY083664

Consensus CDS

CCDS4643.1

UniProtKB/Swiss-Prot

P49910

UniProtKB/TrEMBL

Q53Z40

Related

ENSP00000366542.1, ENST00000377325.2

Conserved Domains (4) summary

smart00431
Location:45 → 157

SCAN; leucine rich region

COG5048
Location:426 → 479

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:402 → 422

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:344 → 366

zf-C2H2; Zinc finger, C2H2 type